Click here to switch to the map view.

The map label for this gene is galE [H]

Identifier: 13507996

GI number: 13507996

Start: 306965

End: 307981

Strand: Direct

Name: galE [H]

Synonym: MPN257

Alternate gene names: 13507996

Gene position: 306965-307981 (Clockwise)

Preceding gene: 13507995

Following gene: 13507997

Centisome position: 37.6

GC content: 41.3

Gene sequence:

>1017_bases
ATGAGTGAAACCAAGAGTAAAGTACTCGTTTTAGGCGGTTTAGGTTACATTGGGAGCTGTTTTATTGACCAGCTTCTAAA
ACAGTACCCTGATGTAACTGTTAGTGTAATTGACATTAACCACACTAGTCTGGCGCTACAACTGTTACCAAGACAGGTCA
ACGTTCACTTTGTTAACTTACTTGACCGTGCACAGTTAACAGATACGATTGCTCAAATTAACCCTGATGTCGTGTTTCAC
TTTGCGGCAAAAACAAGCGTAAAGGAATCGACCGAACAACCACTTACATATTTTGACCATAACCTAGTCGGTACGCTCAA
CTTACTCCACGCTTTAAAAGAACTACAAAAACCGATCCAGCTGTTCTTCTCCTCCACTGCTGCAGTCTTTGGTAGTGCTA
GTACACTTCCAATTCCAGAAAACTTAGTTTTAGAGGAAACACTCGCTTCCAATCCGTATGGCATTAGTAAGTTTTTAAGT
GAAATAGTACTGCAAACACTTACCCGTAGCCCCCATTTTCAAGTAATAGCGTTGCGCTACTTTAACGTAGCGGGTGCTAG
TAATCCCTTTGGTAACTTCAATAAAAACACGACCTTACTGATTCCTAACCTGATTAAAGCCTTTATGGAAAAGCGCACCT
TCTTTCTGTATGGTGATGACTATGACACTAAAGATGGGAGCTGTATCCGTGATTACATCCATGTAGTAGACTTGTGTGAT
GCCCATTTGTTGGCGTGAAAGTGGTTGCAAGCCAATCCTAAAGTGCGCTTTGAAAGCTTTAACTTAGGTAGTGGTCAGGG
CTTTTCCAATTGGGAGGTCATTAATACTGCTCAAGCAATCTTTGCGCCTGAACAATTACAGCTCAAAATTGAATCACGAA
GGGCTGGTGATCCACCTGTTTTAGTGGTTGATTGCACGAAGGCAAAACGCTTACTCAACTTCCAACCAACCCGCTCATTA
CACAAAATGCTGAGCGATGAAACAATTTTTTATCGGGATTTTTATAATAGGCTTTAA

Upstream 100 bases:

>100_bases
CCAACCATGGACTTTTCTAAGTTTATTGATGAATTAGATCAAATTACCAAAAACTTTTCTGATTTAGAGTTAGAACCACT
TAGTTTTAACGAAGGTTTTG

Downstream 100 bases:

>100_bases
ATTCAATTTTGGCAATGTCAAAAATAGCCTTCAGGATGGAAAATATCTGCAAGAGTTTTGACAATGGTAGGGTCAAAGCT
AATGTAGATGTTAACCTCAC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNLLDRAQLTDTIAQINPDVVFH
FAAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQLFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLS
EIVLQTLTRSPHFQVIALRYFNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCD
AHLLAWKWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVLVVDCTKAKRLLNFQPTRSL
HKMLSDETIFYRDFYNRL

Sequences:

>Translated_338_residues
MSETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNLLDRAQLTDTIAQINPDVVFH
FAAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQLFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLS
EIVLQTLTRSPHFQVIALRYFNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCD
AHLLA*KWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVLVVDCTKAKRLLNFQPTRSL
HKMLSDETIFYRDFYNRL
>Mature_337_residues
SETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNLLDRAQLTDTIAQINPDVVFHF
AAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQLFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLSE
IVLQTLTRSPHFQVIALRYFNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCDA
HLLA*KWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVLVVDCTKAKRLLNFQPTRSLH
KMLSDETIFYRDFYNRL

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=339, Percent_Identity=31.858407079646, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI56118217, Length=339, Percent_Identity=31.858407079646, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI189083684, Length=339, Percent_Identity=31.858407079646, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1786974, Length=330, Percent_Identity=35.1515151515151, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI48994969, Length=349, Percent_Identity=24.0687679083095, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788353, Length=353, Percent_Identity=25.2124645892351, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=341, Percent_Identity=31.6715542521994, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71982035, Length=339, Percent_Identity=31.2684365781711, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17568069, Length=256, Percent_Identity=27.734375, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=336, Percent_Identity=36.6071428571429, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19923002, Length=334, Percent_Identity=31.437125748503, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37929; Mature: 37798

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNL
CCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHEEEEECCCHHCCHHHHH
LDRAQLTDTIAQINPDVVFHFAAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQ
HHHHHHHHHHHHCCCCEEEEEEHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
LFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLSEIVLQTLTRSPHFQVIALRY
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEE
FNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCD
EECCCCCCCCCCCCCCCEEECHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
AHLLAKWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCEE
VVDCTKAKRLLNFQPTRSLHKMLSDETIFYRDFYNRL
EEECHHHHHHHCCCCHHHHHHHHCCCEEEEHHHHHCC
>Mature Secondary Structure 
SETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNL
CCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCHHEEEEECCCHHCCHHHHH
LDRAQLTDTIAQINPDVVFHFAAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQ
HHHHHHHHHHHHCCCCEEEEEEHHCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
LFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLSEIVLQTLTRSPHFQVIALRY
HHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEE
FNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCD
EECCCCCCCCCCCCCCCEEECHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
AHLLAKWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCEE
VVDCTKAKRLLNFQPTRSLHKMLSDETIFYRDFYNRL
EEECHHHHHHHCCCCHHHHHHHHCCCEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]