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The map label for this gene is ung [H]

Identifier: 13507974

GI number: 13507974

Start: 286468

End: 287190

Strand: Direct

Name: ung [H]

Synonym: MPN235

Alternate gene names: 13507974

Gene position: 286468-287190 (Clockwise)

Preceding gene: 13507973

Following gene: 13507975

Centisome position: 35.09

GC content: 41.08

Gene sequence:

>723_bases
ATGGAACAACTTTTAGACCAGTTTTTAAGTGGTGTTTTAAGCGAATGGAAGGCTTTTATTTTGCAAGAAGCCAAACAGAC
CTATTTTCAAGAATTGTTAGCTAAACTAAAAAATGTCGAGCAAGAGCTAACTCCCAAAGCCTCTCAAGTCTTTCGTCCCT
TTAGCTTTTTTGCACCAAATAACACTAAACTAATTATTTACGGTCAGGATCCATATCCTAATCCACAACACGCTTGTGGT
CTTTCGTTTGCCTCTAACGCCCCTAAACTACCACAAAGCTTAAAGCGGATGATTCTGCGCTTGCAGCAAGAGTATCCGGA
ACTAGCAGGTCAAAATCACTGAACGAAGCAACTGTTAGAGGGTTGAGCACAACAAGGCATCTTGTTGTTAAATGGCGTCT
TTACCACCAATGCCTTTCAAACCAATGCGCACCGCAATTGGGGGTGAGAGCAGTTTAACTGTCATTTACTCGATTTTCTC
TTGTCACAAAAACTCTATGTACTACTCGTTTTTTTGGGCAAACAAACCGAGAATTTTGTTCTTAAAAAGATTGGTGGAGC
AAGCCAATTTGCTAGTTTATCCTACCCCCATCCCTCACCTTTAACCGGGCGGAAGTTTTTCGATCATCCCGATGCTTTGT
TTAAGCAAATTAACCAGTGATTAAAGCACCATAACCATACTCCAATTGATTGGACTAACGGCCAGGTACAGTACCAGTTC
TAA

Upstream 100 bases:

>100_bases
ACGCACTGGTACAACTAAACCGCCAGTAGTTGATTTAGCGAGCTACCTCCACTTTGTTATTTTGACAGCTAAGTAGTTCA
TTGAGCCGCAAAGGCAGCAA

Downstream 100 bases:

>100_bases
CTGTTTTGGTAAAGTTTTGTCTTTAATTCAACAAACAAAGCTTTAGCATTTTTCATTATTTTTCTTATGATTTTTATTCC
GCTTGTACTCAAACAGAAAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MEQLLDQFLSGVLSEWKAFILQEAKQTYFQELLAKLKNVEQELTPKASQVFRPFSFFAPNNTKLIIYGQDPYPNPQHACG
LSFASNAPKLPQSLKRMILRLQQEYPELAGQNHWTKQLLEGWAQQGILLLNGVFTTNAFQTNAHRNWGWEQFNCHLLDFL
LSQKLYVLLVFLGKQTENFVLKKIGGASQFASLSYPHPSPLTGRKFFDHPDALFKQINQWLKHHNHTPIDWTNGQVQYQF

Sequences:

>Translated_240_residues
MEQLLDQFLSGVLSEWKAFILQEAKQTYFQELLAKLKNVEQELTPKASQVFRPFSFFAPNNTKLIIYGQDPYPNPQHACG
LSFASNAPKLPQSLKRMILRLQQEYPELAGQNH*TKQLLEG*AQQGILLLNGVFTTNAFQTNAHRNWG*EQFNCHLLDFL
LSQKLYVLLVFLGKQTENFVLKKIGGASQFASLSYPHPSPLTGRKFFDHPDALFKQINQ*LKHHNHTPIDWTNGQVQYQF
>Mature_240_residues
MEQLLDQFLSGVLSEWKAFILQEAKQTYFQELLAKLKNVEQELTPKASQVFRPFSFFAPNNTKLIIYGQDPYPNPQHACG
LSFASNAPKLPQSLKRMILRLQQEYPELAGQNH*TKQLLEG*AQQGILLLNGVFTTNAFQTNAHRNWG*EQFNCHLLDFL
LSQKLYVLLVFLGKQTENFVLKKIGGASQFASLSYPHPSPLTGRKFFDHPDALFKQINQ*LKHHNHTPIDWTNGQVQYQF

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=224, Percent_Identity=29.4642857142857, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI19718751, Length=226, Percent_Identity=30.5309734513274, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1788934, Length=219, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17556304, Length=238, Percent_Identity=26.890756302521, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323620, Length=249, Percent_Identity=30.9236947791165, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 27002; Mature: 27002

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLLDQFLSGVLSEWKAFILQEAKQTYFQELLAKLKNVEQELTPKASQVFRPFSFFAPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEECCC
NTKLIIYGQDPYPNPQHACGLSFASNAPKLPQSLKRMILRLQQEYPELAGQNHTKQLLEG
CCEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AQQGILLLNGVFTTNAFQTNAHRNWGEQFNCHLLDFLLSQKLYVLLVFLGKQTENFVLKK
HHCCEEEEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IGGASQFASLSYPHPSPLTGRKFFDHPDALFKQINQLKHHNHTPIDWTNGQVQYQF
HCCHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MEQLLDQFLSGVLSEWKAFILQEAKQTYFQELLAKLKNVEQELTPKASQVFRPFSFFAPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEECCC
NTKLIIYGQDPYPNPQHACGLSFASNAPKLPQSLKRMILRLQQEYPELAGQNHTKQLLEG
CCEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AQQGILLLNGVFTTNAFQTNAHRNWGEQFNCHLLDFLLSQKLYVLLVFLGKQTENFVLKK
HHCCEEEEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IGGASQFASLSYPHPSPLTGRKFFDHPDALFKQINQLKHHNHTPIDWTNGQVQYQF
HCCHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]