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The map label for this gene is pip [H]

Identifier: 13507761

GI number: 13507761

Start: 27316

End: 28245

Strand: Direct

Name: pip [H]

Synonym: MPN022

Alternate gene names: 13507761

Gene position: 27316-28245 (Clockwise)

Preceding gene: 13507760

Following gene: 13507762

Centisome position: 3.35

GC content: 43.55

Gene sequence:

>930_bases
ATGAATACAAGTCCTAAGCAAAGTGGTTATTTAAAGGTTGGTAATGGTCATGAGGTCTACTTTTGAACTGCTGGTAATCC
CCAAGGAAAATCAGCACTTTACGTTCATGGGGGACCAGGTTCGGGTACGGATGCGGGTTGTTTAAAGTACTTTGACTTAG
ACACTACCTATGTAATCTTGTTAGACCAACGGGGTTGTGGTCAAAGTAAAGCGGTTAATCCCTTACTGCACAACACTACC
CAAGACTTAGTTGGGGACTTGGAAGCGTTGCGCCAACACTTAAAACTTGAGCGTTGGACCCTATTTGGTGGTAGTTGGGG
TTCTACTTTAGCCTTAGTGTATGCCATTACCCATCCCCAAGTAGTCGAACAAGTCTTTTTAAGAGCGCTCTTTTTGGGCC
GTGAACAAGACTGGGCTGAAATGCTGTTGGGCTTGGGCAAGCTCTTCTACCCTTACGAACACCAAACGTTACTGAAAGCC
ATTCCCCAGGCTTGTCGCACTGACTTTACGAAATTCACTAACTACTTTTATGAAGTGTTGCAAGGTAACGATTCCGCTTT
AAAAACGCAGTTAGCCAACGCTTGGGTTAAGTGGGAAAATACCTTACTATCACCGATTAGCTATGTCAAAGATGAGAAAG
CAGAAGATGCGAACTTTACCTTTAAGTTAGCGCTCTTGGAATGTCACTACGCAAAGCACCACAGCTTTTTAAAACCGAAC
TTTATCCTGGAAAATGTTGCGGTATTAAAGGACAAACCGGTGCACTTAATCCACGGCCGTTTTGATCTAGTCTGTCCGTT
AAGTCAAGCCTTGGAACTCAAACGTGCTTTACCAACGCTTAACTTGTATGTAACTAACAATGCCGGGCACAGTGGCAGTG
ATCCCAATAACCTCACTACCATTAAACACCTTTTAAAAACACAACTGTAA

Upstream 100 bases:

>100_bases
TATGCCCGTCCAAGTGAATACAGTGCGCCAGAGTTGCGCAAGCTCAAGGAATTTATTAAACCTAATCAAGAGGTAAAACA
ATATTTAAACGCACTTAAGA

Downstream 100 bases:

>100_bases
TGAAACGGTGTTACATTACCACCCCGATTTACTACGCCTCGGGTAAGCCCCACATTGGCCATGCCTTTACGACCATCTTA
GCGGATGTGATTAAGCGGTA

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNTSPKQSGYLKVGNGHEVYFWTAGNPQGKSALYVHGGPGSGTDAGCLKYFDLDTTYVILLDQRGCGQSKAVNPLLHNTT
QDLVGDLEALRQHLKLERWTLFGGSWGSTLALVYAITHPQVVEQVFLRALFLGREQDWAEMLLGLGKLFYPYEHQTLLKA
IPQACRTDFTKFTNYFYEVLQGNDSALKTQLANAWVKWENTLLSPISYVKDEKAEDANFTFKLALLECHYAKHHSFLKPN
FILENVAVLKDKPVHLIHGRFDLVCPLSQALELKRALPTLNLYVTNNAGHSGSDPNNLTTIKHLLKTQL

Sequences:

>Translated_309_residues
MNTSPKQSGYLKVGNGHEVYF*TAGNPQGKSALYVHGGPGSGTDAGCLKYFDLDTTYVILLDQRGCGQSKAVNPLLHNTT
QDLVGDLEALRQHLKLERWTLFGGSWGSTLALVYAITHPQVVEQVFLRALFLGREQDWAEMLLGLGKLFYPYEHQTLLKA
IPQACRTDFTKFTNYFYEVLQGNDSALKTQLANAWVKWENTLLSPISYVKDEKAEDANFTFKLALLECHYAKHHSFLKPN
FILENVAVLKDKPVHLIHGRFDLVCPLSQALELKRALPTLNLYVTNNAGHSGSDPNNLTTIKHLLKTQL
>Mature_309_residues
MNTSPKQSGYLKVGNGHEVYF*TAGNPQGKSALYVHGGPGSGTDAGCLKYFDLDTTYVILLDQRGCGQSKAVNPLLHNTT
QDLVGDLEALRQHLKLERWTLFGGSWGSTLALVYAITHPQVVEQVFLRALFLGREQDWAEMLLGLGKLFYPYEHQTLLKA
IPQACRTDFTKFTNYFYEVLQGNDSALKTQLANAWVKWENTLLSPISYVKDEKAEDANFTFKLALLECHYAKHHSFLKPN
FILENVAVLKDKPVHLIHGRFDLVCPLSQALELKRALPTLNLYVTNNAGHSGSDPNNLTTIKHLLKTQL

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34486; Mature: 34486

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSPKQSGYLKVGNGHEVYFTAGNPQGKSALYVHGGPGSGTDAGCLKYFDLDTTYVILL
CCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEEE
DQRGCGQSKAVNPLLHNTTQDLVGDLEALRQHLKLERWTLFGGSWGSTLALVYAITHPQV
ECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHEEEEECCCCCCCEEEEEEECCHHH
VEQVFLRALFLGREQDWAEMLLGLGKLFYPYEHQTLLKAIPQACRTDFTKFTNYFYEVLQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNDSALKTQLANAWVKWENTLLSPISYVKDEKAEDANFTFKLALLECHYAKHHSFLKPNF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCH
ILENVAVLKDKPVHLIHGRFDLVCPLSQALELKRALPTLNLYVTNNAGHSGSDPNNLTTI
HHHHHHHHCCCCEEEECCCEEEECCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHH
KHLLKTQL
HHHHHHCC
>Mature Secondary Structure
MNTSPKQSGYLKVGNGHEVYFTAGNPQGKSALYVHGGPGSGTDAGCLKYFDLDTTYVILL
CCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEEE
DQRGCGQSKAVNPLLHNTTQDLVGDLEALRQHLKLERWTLFGGSWGSTLALVYAITHPQV
ECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHEEEEECCCCCCCEEEEEEECCHHH
VEQVFLRALFLGREQDWAEMLLGLGKLFYPYEHQTLLKAIPQACRTDFTKFTNYFYEVLQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNDSALKTQLANAWVKWENTLLSPISYVKDEKAEDANFTFKLALLECHYAKHHSFLKPNF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCH
ILENVAVLKDKPVHLIHGRFDLVCPLSQALELKRALPTLNLYVTNNAGHSGSDPNNLTTI
HHHHHHHHCCCCEEEECCCEEEECCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHH
KHLLKTQL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]