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The map label for this gene is htpX

Identifier: 15669878

GI number: 15669878

Start: 1664008

End: 1664862

Strand: Reverse

Name: htpX

Synonym: MJ1682

Alternate gene names: 15669878

Gene position: 1664862-1664008 (Counterclockwise)

Preceding gene: NA

Following gene: 15669877

Centisome position: 99.99

GC content: 35.56

Gene sequence:

>855_bases
ATGATAAATCAAATAAAGACCTATTTATTAATGGCTTTACTTGTAGGGTTAATTTATGCAATTTGTATGATGTTGCATAT
ACATCCATTGATAGCCATAATCTTAGCTTTAATTCCAAATGTTATTGCATATTATATGAGTGATAAACTTGTATTAATGA
GTTACAACGCAAGGATTTTAGAAGAGCATGAGATGCCTTGGTTACATCAAATGGTCGAAAGAGTTGCAAGAAAAGCTGGA
CTACCAAAACCAAAAGTTGCTATAGTTCCAACTGAAACACCAAATGCGTTTGCTACGGGTAGAAATCCAGAAAATGCCGT
AGTGGCTGTAACCGAAGGAATATTAAAATTACTATCCCCAGAAGAATTAGAAGGAGTCATTGGACATGAAATATCTCACA
TAAAACATAGAGACATCTTAATAAGCACTATAGTAGCCACTTTAGCTGGAGCTATAGTAATGATTGCAGAGTGGATGCTA
TACTGGGGAGGAATTTTCTTTGTTTCTGAAGAGGAGGAGAGTAATCCATTAGAGTTAATTGGAACGATTTTGTTATTAAT
ATTAGCTCCAATTGCTGCTACAATAATACAGTTTGCAATTTCAAGACAGAGAGAGTTTTACGCAGATGAAGAGGGAGCTA
AGCTAACACATCCATTGTGGCTGGCTAATGCGTTAGCTAAGTTAGAAAGAGGGGTAGAGTTATACCCATTGGAGAGAGGA
AATCCAGCAACAGCTCACATGTTTATAATAAACCCATTTAGAAAAGATTTTATTGCCAAACTTTTCTCAACACACCCTCC
AACTGAAGAGAGAATTGAAAGACTGTTAGAGATGTGCAAAAGAATTGGAAAATAA

Upstream 100 bases:

>100_bases
TATTAATGCCCTACGGATAATAAAATTAGCAACGTAAATTATTTAAGCATTTTGTATTTACAATATTTTTAAACAAAGTT
TTAAATGAGTGTGATGGATT

Downstream 100 bases:

>100_bases
AAAGGTGGCATTGTGGAAAAGGAATTAAAAGTAATAACAATAGATGAACTAAAAAAATACATTAGAAATAATGAAGAGGA
CAAGATAGAGGAGGTTGATG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MINQIKTYLLMALLVGLIYAICMMLHIHPLIAIILALIPNVIAYYMSDKLVLMSYNARILEEHEMPWLHQMVERVARKAG
LPKPKVAIVPTETPNAFATGRNPENAVVAVTEGILKLLSPEELEGVIGHEISHIKHRDILISTIVATLAGAIVMIAEWML
YWGGIFFVSEEEESNPLELIGTILLLILAPIAATIIQFAISRQREFYADEEGAKLTHPLWLANALAKLERGVELYPLERG
NPATAHMFIINPFRKDFIAKLFSTHPPTEERIERLLEMCKRIGK

Sequences:

>Translated_284_residues
MINQIKTYLLMALLVGLIYAICMMLHIHPLIAIILALIPNVIAYYMSDKLVLMSYNARILEEHEMPWLHQMVERVARKAG
LPKPKVAIVPTETPNAFATGRNPENAVVAVTEGILKLLSPEELEGVIGHEISHIKHRDILISTIVATLAGAIVMIAEWML
YWGGIFFVSEEEESNPLELIGTILLLILAPIAATIIQFAISRQREFYADEEGAKLTHPLWLANALAKLERGVELYPLERG
NPATAHMFIINPFRKDFIAKLFSTHPPTEERIERLLEMCKRIGK
>Mature_284_residues
MINQIKTYLLMALLVGLIYAICMMLHIHPLIAIILALIPNVIAYYMSDKLVLMSYNARILEEHEMPWLHQMVERVARKAG
LPKPKVAIVPTETPNAFATGRNPENAVVAVTEGILKLLSPEELEGVIGHEISHIKHRDILISTIVATLAGAIVMIAEWML
YWGGIFFVSEEEESNPLELIGTILLLILAPIAATIIQFAISRQREFYADEEGAKLTHPLWLANALAKLERGVELYPLERG
NPATAHMFIINPFRKDFIAKLFSTHPPTEERIERLLEMCKRIGK

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=291, Percent_Identity=32.3024054982818, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_METJA (Q59076)

Other databases:

- EMBL:   L77117
- PIR:   H64509
- RefSeq:   NP_248692.1
- ProteinModelPortal:   Q59076
- MEROPS:   M48.004
- GeneID:   1452591
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1682
- NMPDR:   fig|243232.1.peg.1729
- TIGR:   MJ1682
- HOGENOM:   HBG739460
- OMA:   ISMIGNM
- ProtClustDB:   PRK03982
- BioCyc:   MJAN243232:MJ_1682-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31973; Mature: 31973

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

HASH(0xf1fc1fc)-; HASH(0xf3c6fd4)-; HASH(0xf3c4338)-; HASH(0xf3af784)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINQIKTYLLMALLVGLIYAICMMLHIHPLIAIILALIPNVIAYYMSDKLVLMSYNARIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
EEHEMPWLHQMVERVARKAGLPKPKVAIVPTETPNAFATGRNPENAVVAVTEGILKLLSP
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCH
EELEGVIGHEISHIKHRDILISTIVATLAGAIVMIAEWMLYWGGIFFVSEEEESNPLELI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
GTILLLILAPIAATIIQFAISRQREFYADEEGAKLTHPLWLANALAKLERGVELYPLERG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
NPATAHMFIINPFRKDFIAKLFSTHPPTEERIERLLEMCKRIGK
CCCEEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MINQIKTYLLMALLVGLIYAICMMLHIHPLIAIILALIPNVIAYYMSDKLVLMSYNARIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
EEHEMPWLHQMVERVARKAGLPKPKVAIVPTETPNAFATGRNPENAVVAVTEGILKLLSP
HHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCH
EELEGVIGHEISHIKHRDILISTIVATLAGAIVMIAEWMLYWGGIFFVSEEEESNPLELI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
GTILLLILAPIAATIIQFAISRQREFYADEEGAKLTHPLWLANALAKLERGVELYPLERG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
NPATAHMFIINPFRKDFIAKLFSTHPPTEERIERLLEMCKRIGK
CCCEEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087