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The map label for this gene is purC

Identifier: 15669787

GI number: 15669787

Start: 1564597

End: 1565325

Strand: Direct

Name: purC

Synonym: MJ1592

Alternate gene names: 15669787

Gene position: 1564597-1565325 (Clockwise)

Preceding gene: 15669786

Following gene: 15669788

Centisome position: 93.97

GC content: 31.82

Gene sequence:

>729_bases
ATGGAGATAAAATTAGAAGAAATTCTAAAAAAACAGCCATTATACAGTGGAAAGGCAAAGTCAATCTATGAGATTGATGA
TGATAAAGTTTTGATAGAGTTTAGAGATGATATAACAGCTGGAAATGGAGCTAAGCATGATGTCAAACAAGGAAAAGGTT
ACTTAAATGCTCTAATCTCATCAAAGTTATTTGAGGCTTTAGAGGAAAATGGAGTCAAAACCCACTATATAAAGTATATA
GAACCAAGATACATGATAGCTAAAAAAGTTGAGATAATTCCAATTGAGGTTATAGTTAGAAATATAGCTGCTGGAAGTTT
GTGTAGAAGATATCCTTTTGAAGAAGGGAAAGAATTGCCATTTCCAATTGTTCAATTTGACTATAAAAATGATGAGTATG
GAGACCCAATGCTAAATGAAGATATTGCTGTAGCTTTAGGTTTAGCTACAAGAGAGGAGCTAAATAAAATTAAAGAAATT
GCTTTAAAGGTTAATGAAGTATTAAAGAAATTGTTTGATGAGAAGGGCATTATATTAGTTGATTTCAAAATTGAAATTGG
TAAAGATAGGGAAGGCAATTTATTAGTTGCAGATGAGATAAGCCCAGATACTATGAGATTGTGGGATAAGGAGACACGAG
ATGTCTTAGATAAGGATGTATTTAGAAAGGATTTAGGGGATGTTATTGCAAAATACAGAATTGTCGCTGAGAGATTGGGA
TTATTATAA

Upstream 100 bases:

>100_bases
AAGAACTATAAATTTTTTATATTACATTGTAAGTATAAAGATTAAAAATTAAATGAGAGTTTTAATAATTAAAATTTAAA
GTTATAGCTAAGGTGAAAGT

Downstream 100 bases:

>100_bases
AGCAATAAGGTGAAATTATGTATAAGGCAACAGTTATAATAAAGTTAAAAAAAGGAGTTCTAAATCCAGAAGGAAGGACA
ATACAGAGAGCTTTAAACTT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MEIKLEEILKKQPLYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALISSKLFEALEENGVKTHYIKYI
EPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELPFPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEI
ALKVNEVLKKLFDEKGIILVDFKIEIGKDREGNLLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERLG
LL

Sequences:

>Translated_242_residues
MEIKLEEILKKQPLYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALISSKLFEALEENGVKTHYIKYI
EPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELPFPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEI
ALKVNEVLKKLFDEKGIILVDFKIEIGKDREGNLLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERLG
LL
>Mature_242_residues
MEIKLEEILKKQPLYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALISSKLFEALEENGVKTHYIKYI
EPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELPFPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEI
ALKVNEVLKKLFDEKGIILVDFKIEIGKDREGNLLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERLG
LL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=249, Percent_Identity=34.9397590361446, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI5453539, Length=249, Percent_Identity=34.9397590361446, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI119220559, Length=256, Percent_Identity=33.984375, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=233, Percent_Identity=43.3476394849785, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17531275, Length=219, Percent_Identity=33.7899543378995, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319326, Length=266, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18860083, Length=242, Percent_Identity=32.2314049586777, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583917, Length=244, Percent_Identity=29.9180327868852, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_METJA (Q58987)

Other databases:

- EMBL:   L77117
- PIR:   G64498
- RefSeq:   NP_248601.1
- PDB:   2YZL
- PDB:   2Z02
- PDBsum:   2YZL
- PDBsum:   2Z02
- ProteinModelPortal:   Q58987
- SMR:   Q58987
- GeneID:   1452500
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1592
- NMPDR:   fig|243232.1.peg.1638
- TIGR:   MJ1592
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   MJAN243232:MJ_1592-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27762; Mature: 27762

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKLEEILKKQPLYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALIS
CCCCHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SKLFEALEENGVKTHYIKYIEPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELP
HHHHHHHHHCCCEEEEEEECCCHHHHHHHCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCC
FPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEIALKVNEVLKKLFDEKGIILV
CCEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DFKIEIGKDREGNLLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERLG
EEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LL
CC
>Mature Secondary Structure
MEIKLEEILKKQPLYSGKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALIS
CCCCHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SKLFEALEENGVKTHYIKYIEPRYMIAKKVEIIPIEVIVRNIAAGSLCRRYPFEEGKELP
HHHHHHHHHCCCEEEEEEECCCHHHHHHHCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCC
FPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEIALKVNEVLKKLFDEKGIILV
CCEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DFKIEIGKDREGNLLVADEISPDTMRLWDKETRDVLDKDVFRKDLGDVIAKYRIVAERLG
EEEEEECCCCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087