Click here to switch to the map view.

The map label for this gene is guaAA

Identifier: 15669771

GI number: 15669771

Start: 1550945

End: 1551511

Strand: Direct

Name: guaAA

Synonym: MJ1575

Alternate gene names: 15669771

Gene position: 1550945-1551511 (Clockwise)

Preceding gene: 15669767

Following gene: 15669772

Centisome position: 93.15

GC content: 34.39

Gene sequence:

>567_bases
ATGATTGTTATCTTAGACAACGGAGGGCAGTATGTTCATAGAATACACAGAAGTTTAAAGTATATTGGAGTTAGCTCAAA
GATAGTTCCAAATACAACACCATTGGAAGAGATTGAAAGCAATAAAGAAGTTAAGGGTATTATACTAAGTGGAGGGCCTG
ATATTGAAAAAGCTAAAAATTGTATAGATATTGCTTTAAATGCTAAACTCCCTATTTTGGGGATTTGTTTAGGACATCAA
TTAATTGCCTTGGCTTATGGTGGAGAGGTTGGAAGGGCTGAGGCAGAAGAATACGCACTAACAAAGGTCTATGTAGATAA
AGAAAACGATTTATTTAAAAACGTTCCAAGAGAGTTCAATGCATGGGCTTCACATAAGGATGAGGTTAAAAAAGTTCCAG
AAGGTTTTGAGATTTTAGCTCATTCAGATATATGTCAGGTTGAAGCAATGAAACATAAAACAAAGCCGATTTATGGAGTT
CAGTTCCACCCTGAAGTTGCTCATACAGAATATGGAAATGAGATTTTGAAAAACTTTTGTAAAGTTTGTGGTTACAAATT
TGAATAA

Upstream 100 bases:

>100_bases
CGAGCGTAAGCGAGGAGGTGTTAGATTTTTGATGAACCTTTTACTAAAAGGTTCTTTCAAAATGTTTTTGAAAGATACTA
ATAAAATATAAGGTGATAAA

Downstream 100 bases:

>100_bases
CTAATAATAAAATTTATATAAGTTGATATCAAACATACTAAACTATCCAAATAATTCAAATTCTTTTTTGTGGTGAAATT
ATGTTAATGTTATTGTTAAT

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNCIDIALNAKLPILGICLGHQ
LIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGV
QFHPEVAHTEYGNEILKNFCKVCGYKFE

Sequences:

>Translated_188_residues
MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNCIDIALNAKLPILGICLGHQ
LIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGV
QFHPEVAHTEYGNEILKNFCKVCGYKFE
>Mature_188_residues
MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNCIDIALNAKLPILGICLGHQ
LIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGV
QFHPEVAHTEYGNEILKNFCKVCGYKFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=181, Percent_Identity=37.5690607734807, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788854, Length=194, Percent_Identity=31.4432989690722, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789760, Length=184, Percent_Identity=28.804347826087, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787517, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901714, Length=190, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992717, Length=190, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992710, Length=190, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323873, Length=184, Percent_Identity=40.7608695652174, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=197, Percent_Identity=26.9035532994924, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365319, Length=181, Percent_Identity=37.0165745856354, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_METJA (Q58970)

Other databases:

- EMBL:   L77117
- PIR:   F64496
- RefSeq:   NP_248584.1
- ProteinModelPortal:   Q58970
- SMR:   Q58970
- GeneID:   1452484
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1575
- NMPDR:   fig|243232.1.peg.1621
- TIGR:   MJ1575
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BioCyc:   MJAN243232:MJ_1575-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 21020; Mature: 21020

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 76-76 ACT_SITE 163-163 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKN
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCHHHHHC
CIDIALNAKLPILGICLGHQLIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFN
EEEEEECCCCCEEHHHHHHHHEEEEECCCCCCCCHHHEEEEEEEECCCCCHHHHCCHHHH
AWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGVQFHPEVAHTEYGNEILKNFC
HHCCCHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
KVCGYKFE
HHCCCCCC
>Mature Secondary Structure
MIVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKN
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCHHHHHC
CIDIALNAKLPILGICLGHQLIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPREFN
EEEEEECCCCCEEHHHHHHHHEEEEECCCCCCCCHHHEEEEEEEECCCCCHHHHCCHHHH
AWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGVQFHPEVAHTEYGNEILKNFC
HHCCCHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
KVCGYKFE
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087