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The map label for this gene is lhr [C]

Identifier: 15669770

GI number: 15669770

Start: 1548401

End: 1550455

Strand: Reverse

Name: lhr [C]

Synonym: MJ1574

Alternate gene names: 15669770

Gene position: 1550455-1548401 (Counterclockwise)

Preceding gene: 15669775

Following gene: 15669769

Centisome position: 93.12

GC content: 31.0

Gene sequence:

>2055_bases
ATGGAAGATGTATTTAAAGGCATTGAAAAAGAAATTATAAAGATTTACAAAATCCCAGAGAGGAAAGGGAGATTCTCCAA
CTTCAAATTTAAAAATAAAGAGATTAATGAGCTAATTGATGCCTTAGGATTTAAATTATATTTACATCAAGTTAAGGCTT
TAAAGTATCTCTACAATAAAAAAGATGTGGTTGTTACAACATCAACAGCAAGTGGAAAGAGTGAGATTTTTAGATTGGCT
ATATTTGACAACTTCTTGTCAAATCCTGACGATAGGTATCTGCTTATTTATCCAACAAGGGCATTGATAAACAACCAATA
TGAAAAATTCTCTATGGAGAATGAGCTATTTTATAAAATAACTAACAAGAGAGTTAAAGCAGAGATATTAACTGGAGATG
TGGGCTTAGAGAAAAGAAGGGAGATTTTGAAGGATAAGCCAAATGTATTATTTACAACTCCAGATATGCTTCACTATCAA
ATATTAAAAAACCACAACAACTATTTATGGCTTTTAAAGAATTTAAAGCTCTTAGTTGTTGATGAACTCCACGTTTATAG
GGGAGTCTTTGGAACAAACATGGTTTATGTTTTTAAGAGATTGTTAAAGCTTTTGAAGAGATTAAATAACAATTTGCAGA
TACTCTGCCTCTCTGCAACTTTAAAAAACCCAAAAGAGTTTGTTAAATTGTTGTTTAATAGAGATTTTGAGGTTGTTGAT
AAAAGCTACAATCCTTCATCAAGGAAGTATTTAGCAATCTTAGAGCCAAAGAATTTGGACAATAAACAGTTGTTGAGAAG
ATTGATAGAGAATTTAGTAGATAACAATATAAAAACTCTTGTATTCTTTGATACAAGGAAAGAGACAGAGAAGTTGATGA
GATTTTTATTAAATTCTAAGGTTTTTTATAAACTCTCAACCTATAAAGGCACTCTGCCAAAGTATGTCAGGGAGGAGATA
GAGGAGAAGTTTAAAAATGGGGAGATATTAGCTTTATTAACAACCAATGCTTTAGAGCTTGGAATTGATATTGGAGATTT
AGATGCAGTTATAAACTATGGTATTCCACCAGATGGCATATTTTCATTAATTCAGAGGTTTGGTAGGGCTGGGAGGAGAG
ATAAAGAAGCTTTAAACATCATAGTTCTAAGGAAGGACGGTTTAGATTATTACTATAAAGAGCATCTAAATGAGCTTTAT
GAGAGGATTAGGAAAGGAATTATTGAATACATGCCAGTAAATATAAAAAATAGATTTGTTACTAAGAAGCACTTGCATTA
TTTAATCTCTGAGTTAAAAATAGTGGATTTTGATGAACTTAATGACTTTGAGAAGGAGATAGTTAAAGAACTTGAGAGAG
AAGGGAAGATAAAGATTTATAAAAACCCAATAACCAACAAGACAGAGATAAGGAATGTAAAACAGCCTATTTATTCATCA
ATAAGAACTGCAAGTGATGAGAGCTATTATTTAATCTTAGATAAACCATGGATTAAATCTAAATTGTTAAATAAAACCCA
AAGTGAGATTTTGAGTTTTATAAATTGGCTTAAGATTAAGGGCTATGTTATTGAAGAGGTTGATAAAGATGAGTATTACC
GCTCTCTAATTACTGGAATGCCCTATTTTTCAAGAGGGAAGCTGTTTATAGCCAAGGACAAGATAGGTATTAGGAAATTT
CATTTTATATTTGCCGATGAGTTGGATATGTTTTGGGATGTTGAAGCACTGCAGAAGAAAGAGGAAGAGATTGACATCTT
AGATATTTATGATAAAAAGAGCTATAAGGATATAGACATCTATTATGGAAGATTGAGAGTTAGGAAGATTTATGAGGGAT
TTATTGTTAGAGGAGTTGATGTTGATAAATACTATCAAGAGCTTTTAGCTCTAAAAGATAATGGCATCTTAGATGCAGAG
ATTGATTTATTTAAGGATTTCTTTGGCTTGAACTTTATAAGTGTTAAGTTTAACAAAAAGATTATTAGAGACTTTGAGAC
AGATGGAATATGGTTATGTTATTTCCAGATTATATTAGGGATGTTAACCAAATGA

Upstream 100 bases:

>100_bases
AAATATCCAAGATTACAAATCTATTTAGCATTAATCATTAAAAATTTATTTCCCAGTATAAATAACGTTTATGGAAAAGA
TTCAATAGAAGATGATTGTC

Downstream 100 bases:

>100_bases
AGAGTTCTTTGAGTTTCTTGGATAAGATAGAAGAGGATGATTTAGCTATCTCAATCTATAGAGATAGAAAACTCAGCAGA
AAAGAGCTATTTCCAATTTA

Product: EIF-4a family ATP-dependent RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MEDVFKGIEKEIIKIYKIPERKGRFSNFKFKNKEINELIDALGFKLYLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLA
IFDNFLSNPDDRYLLIYPTRALINNQYEKFSMENELFYKITNKRVKAEILTGDVGLEKRREILKDKPNVLFTTPDMLHYQ
ILKNHNNYLWLLKNLKLLVVDELHVYRGVFGTNMVYVFKRLLKLLKRLNNNLQILCLSATLKNPKEFVKLLFNRDFEVVD
KSYNPSSRKYLAILEPKNLDNKQLLRRLIENLVDNNIKTLVFFDTRKETEKLMRFLLNSKVFYKLSTYKGTLPKYVREEI
EEKFKNGEILALLTTNALELGIDIGDLDAVINYGIPPDGIFSLIQRFGRAGRRDKEALNIIVLRKDGLDYYYKEHLNELY
ERIRKGIIEYMPVNIKNRFVTKKHLHYLISELKIVDFDELNDFEKEIVKELEREGKIKIYKNPITNKTEIRNVKQPIYSS
IRTASDESYYLILDKPWIKSKLLNKTQSEILSFINWLKIKGYVIEEVDKDEYYRSLITGMPYFSRGKLFIAKDKIGIRKF
HFIFADELDMFWDVEALQKKEEEIDILDIYDKKSYKDIDIYYGRLRVRKIYEGFIVRGVDVDKYYQELLALKDNGILDAE
IDLFKDFFGLNFISVKFNKKIIRDFETDGIWLCYFQIILGMLTK

Sequences:

>Translated_684_residues
MEDVFKGIEKEIIKIYKIPERKGRFSNFKFKNKEINELIDALGFKLYLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLA
IFDNFLSNPDDRYLLIYPTRALINNQYEKFSMENELFYKITNKRVKAEILTGDVGLEKRREILKDKPNVLFTTPDMLHYQ
ILKNHNNYLWLLKNLKLLVVDELHVYRGVFGTNMVYVFKRLLKLLKRLNNNLQILCLSATLKNPKEFVKLLFNRDFEVVD
KSYNPSSRKYLAILEPKNLDNKQLLRRLIENLVDNNIKTLVFFDTRKETEKLMRFLLNSKVFYKLSTYKGTLPKYVREEI
EEKFKNGEILALLTTNALELGIDIGDLDAVINYGIPPDGIFSLIQRFGRAGRRDKEALNIIVLRKDGLDYYYKEHLNELY
ERIRKGIIEYMPVNIKNRFVTKKHLHYLISELKIVDFDELNDFEKEIVKELEREGKIKIYKNPITNKTEIRNVKQPIYSS
IRTASDESYYLILDKPWIKSKLLNKTQSEILSFINWLKIKGYVIEEVDKDEYYRSLITGMPYFSRGKLFIAKDKIGIRKF
HFIFADELDMFWDVEALQKKEEEIDILDIYDKKSYKDIDIYYGRLRVRKIYEGFIVRGVDVDKYYQELLALKDNGILDAE
IDLFKDFFGLNFISVKFNKKIIRDFETDGIWLCYFQIILGMLTK
>Mature_684_residues
MEDVFKGIEKEIIKIYKIPERKGRFSNFKFKNKEINELIDALGFKLYLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLA
IFDNFLSNPDDRYLLIYPTRALINNQYEKFSMENELFYKITNKRVKAEILTGDVGLEKRREILKDKPNVLFTTPDMLHYQ
ILKNHNNYLWLLKNLKLLVVDELHVYRGVFGTNMVYVFKRLLKLLKRLNNNLQILCLSATLKNPKEFVKLLFNRDFEVVD
KSYNPSSRKYLAILEPKNLDNKQLLRRLIENLVDNNIKTLVFFDTRKETEKLMRFLLNSKVFYKLSTYKGTLPKYVREEI
EEKFKNGEILALLTTNALELGIDIGDLDAVINYGIPPDGIFSLIQRFGRAGRRDKEALNIIVLRKDGLDYYYKEHLNELY
ERIRKGIIEYMPVNIKNRFVTKKHLHYLISELKIVDFDELNDFEKEIVKELEREGKIKIYKNPITNKTEIRNVKQPIYSS
IRTASDESYYLILDKPWIKSKLLNKTQSEILSFINWLKIKGYVIEEVDKDEYYRSLITGMPYFSRGKLFIAKDKIGIRKF
HFIFADELDMFWDVEALQKKEEEIDILDIYDKKSYKDIDIYYGRLRVRKIYEGFIVRGVDVDKYYQELLALKDNGILDAE
IDLFKDFFGLNFISVKFNKKIIRDFETDGIWLCYFQIILGMLTK

Specific function: Unknown

COG id: COG1205

COG function: function code R; Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain

Homologues:

Organism=Homo sapiens, GI50659095, Length=390, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI224593278, Length=368, Percent_Identity=22.2826086956522, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI51094101, Length=357, Percent_Identity=26.6106442577031, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI164419743, Length=357, Percent_Identity=26.6106442577031, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI20149629, Length=395, Percent_Identity=24.3037974683544, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI262118318, Length=362, Percent_Identity=25.1381215469613, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI262231852, Length=362, Percent_Identity=25.1381215469613, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI216548263, Length=362, Percent_Identity=25.1381215469613, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI13518015, Length=362, Percent_Identity=25.1381215469613, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790214, Length=369, Percent_Identity=24.1192411924119, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17510559, Length=373, Percent_Identity=22.7882037533512, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987143, Length=379, Percent_Identity=22.6912928759894, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320497, Length=412, Percent_Identity=33.7378640776699, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323021, Length=346, Percent_Identity=24.5664739884393, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321856, Length=348, Percent_Identity=25.2873563218391, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI9755332, Length=387, Percent_Identity=23.7726098191214, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320224, Length=349, Percent_Identity=22.9226361031519, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24582080, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24582078, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17136248, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24582075, Length=330, Percent_Identity=23.6363636363636, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1574_METJA (Q58969)

Other databases:

- EMBL:   L77117
- PIR:   E64496
- RefSeq:   NP_248583.1
- ProteinModelPortal:   Q58969
- SMR:   Q58969
- GeneID:   1452483
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1574
- NMPDR:   fig|243232.1.peg.1620
- TIGR:   MJ1574
- HOGENOM:   HBG727081
- ProtClustDB:   CLSK254374
- BioCyc:   MJAN243232:MJ_1574-MONOMER
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- SMART:   SM00487
- SMART:   SM00490

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C

EC number: 3.6.1.- [C]

Molecular weight: Translated: 81281; Mature: 81281

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVFKGIEKEIIKIYKIPERKGRFSNFKFKNKEINELIDALGFKLYLHQVKALKYLYNK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KDVVVTTSTASGKSEIFRLAIFDNFLSNPDDRYLLIYPTRALINNQYEKFSMENELFYKI
CCEEEEECCCCCHHHHEEHHHHHHHHCCCCCCEEEEEECHHHHCCCHHHHCCCCCEEEEE
TNKRVKAEILTGDVGLEKRREILKDKPNVLFTTPDMLHYQILKNHNNYLWLLKNLKLLVV
ECCEEEEEEEECCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEECCEEEEE
DELHVYRGVFGTNMVYVFKRLLKLLKRLNNNLQILCLSATLKNPKEFVKLLFNRDFEVVD
EHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHC
KSYNPSSRKYLAILEPKNLDNKQLLRRLIENLVDNNIKTLVFFDTRKETEKLMRFLLNSK
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCC
VFYKLSTYKGTLPKYVREEIEEKFKNGEILALLTTNALELGIDIGDLDAVINYGIPPDGI
EEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHHHHCCCCCCHHH
FSLIQRFGRAGRRDKEALNIIVLRKDGLDYYYKEHLNELYERIRKGIIEYMPVNIKNRFV
HHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TKKHLHYLISELKIVDFDELNDFEKEIVKELEREGKIKIYKNPITNKTEIRNVKQPIYSS
HHHHHHHHHHHCEEECHHHCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
IRTASDESYYLILDKPWIKSKLLNKTQSEILSFINWLKIKGYVIEEVDKDEYYRSLITGM
HHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCC
PYFSRGKLFIAKDKIGIRKFHFIFADELDMFWDVEALQKKEEEIDILDIYDKKSYKDIDI
CCCCCCEEEEEECCCCCEEEEEEEECCHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEE
YYGRLRVRKIYEGFIVRGVDVDKYYQELLALKDNGILDAEIDLFKDFFGLNFISVKFNKK
EEHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCEEEEEEECHH
IIRDFETDGIWLCYFQIILGMLTK
HHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDVFKGIEKEIIKIYKIPERKGRFSNFKFKNKEINELIDALGFKLYLHQVKALKYLYNK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
KDVVVTTSTASGKSEIFRLAIFDNFLSNPDDRYLLIYPTRALINNQYEKFSMENELFYKI
CCEEEEECCCCCHHHHEEHHHHHHHHCCCCCCEEEEEECHHHHCCCHHHHCCCCCEEEEE
TNKRVKAEILTGDVGLEKRREILKDKPNVLFTTPDMLHYQILKNHNNYLWLLKNLKLLVV
ECCEEEEEEEECCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEECCEEEEE
DELHVYRGVFGTNMVYVFKRLLKLLKRLNNNLQILCLSATLKNPKEFVKLLFNRDFEVVD
EHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHC
KSYNPSSRKYLAILEPKNLDNKQLLRRLIENLVDNNIKTLVFFDTRKETEKLMRFLLNSK
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCC
VFYKLSTYKGTLPKYVREEIEEKFKNGEILALLTTNALELGIDIGDLDAVINYGIPPDGI
EEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHHHHCCCCCCHHH
FSLIQRFGRAGRRDKEALNIIVLRKDGLDYYYKEHLNELYERIRKGIIEYMPVNIKNRFV
HHHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TKKHLHYLISELKIVDFDELNDFEKEIVKELEREGKIKIYKNPITNKTEIRNVKQPIYSS
HHHHHHHHHHHCEEECHHHCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
IRTASDESYYLILDKPWIKSKLLNKTQSEILSFINWLKIKGYVIEEVDKDEYYRSLITGM
HHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCC
PYFSRGKLFIAKDKIGIRKFHFIFADELDMFWDVEALQKKEEEIDILDIYDKKSYKDIDI
CCCCCCEEEEEECCCCCEEEEEEEECCHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEE
YYGRLRVRKIYEGFIVRGVDVDKYYQELLALKDNGILDAEIDLFKDFFGLNFISVKFNKK
EEHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCEEEEEEECHH
IIRDFETDGIWLCYFQIILGMLTK
HHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087