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The map label for this gene is yceE [C]

Identifier: 15669755

GI number: 15669755

Start: 1535267

End: 1536427

Strand: Reverse

Name: yceE [C]

Synonym: MJ1560

Alternate gene names: 15669755

Gene position: 1536427-1535267 (Counterclockwise)

Preceding gene: 15669756

Following gene: 15669753

Centisome position: 92.28

GC content: 30.49

Gene sequence:

>1161_bases
ATGGGAAAATTAGAGAAAAATGTTTTTGTTATTTGGATTACTACCTTTACAACTATGCTTGGTGTTGGTTTTATAGCACC
AATTATGGCAATATACGCCCAAACACTGGGAGCTACAAATTTAGAAATTGGTTTAATATTTGGTTCATTTGCATTAGCGA
GAACAGTAGCTCAAATTCCTGTTGGAGTTTTATCTGATATATATGGAAAGAAGTTTTTTATTGTCTGTGGAACATTTTTT
TATGGAGTCTCTACCTTAATGTATAATTTTGTTAGCACAGTTTTAGGTTTTTTAATTGTGAGAATTTTTACTGGAATCTT
TTCAGCTTTTGTAACACCAGTAGCTGGGTCTTATATCGCGGCTATAGCCCCAAAAACAAGATTAGGAGAATATATGGGAA
TTTTTAATTCAGCAATTACATTGGGCTTTGGCATAGGACCTTTTATAGGGGGAATTCTTGCTGATATGTATGGAATTAAA
ATGCCATTCTACTTTTGTGGATTTTTAGGAATTTTGGCGGCAATTATAAGCTATATGAAATTGGAGGATATTGTTTTTAA
TAAAAATAAAGAAAAAATAGATGTTAAAAAAATATCTACTTTATTCTCATTTGAATTTTTGAAAAATAGGAATTTTTCAT
CCTCTTTTATTATCAATGTATCTAATGTTATGATAAATGCTGGGATATATGCGTATTTGGCATTGTATGCAATTAACTAC
AATATAACTATAAGTCAAGTAGGTTTTATGATTGCTTTAACAAATATCTTAATGGCTTTACTTCAAAGAAGTTTTGGAAA
ACTCTACGATAAATTGGGAAATATAATGATAATCATTGGAATTTTTATAATATCCTTTGGAATGTATTTGCTCTCAACCT
CTACAACTTTTTTGACTATATTGGCTTCTTTAACAATTATAGCAGTTGGTAGTTCAATATCTTCCACCGCCACAACATCT
CTCGCAGTTAAAGACATCCCAACACATAGAAAAGGCGAAGCTATGGGGCTTTTTACAACAAGCATAAATATTGGGATGTT
TATTGGTGCAGTGTCGTTTGGATTCTTAGCTGATATTTTAGGAATAGCAAATATGTATAAATTTTCAGCAATATTTTCAA
TTGTTGTAGGGATTATCAGCTATTTAAGAATAGAAAGATAA

Upstream 100 bases:

>100_bases
AGAAAAAATAGCAAAGATAAAGAATAAAACACTCTATTTATTTTTGTTTTTTGAATTTTTCCTATTTCATTTTTTTATTT
TAACGTTTTTAGGTGGTTTT

Downstream 100 bases:

>100_bases
AGATAATTATTTTAATCCTGCCAATATTTTATTTAATATTTCTTCAAACAATTTCTCCCTATTTTCAATAGTTAAAGTAT
ATAGCTCTCCTTTATCTTTA

Product: multidrug-efflux transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGKLEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIPVGVLSDIYGKKFFIVCGTFF
YGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIAAIAPKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIK
MPFYFCGFLGILAAIISYMKLEDIVFNKNKEKIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGIYAYLALYAINY
NITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMIIIGIFIISFGMYLLSTSTTFLTILASLTIIAVGSSISSTATTS
LAVKDIPTHRKGEAMGLFTTSINIGMFIGAVSFGFLADILGIANMYKFSAIFSIVVGIISYLRIER

Sequences:

>Translated_386_residues
MGKLEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIPVGVLSDIYGKKFFIVCGTFF
YGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIAAIAPKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIK
MPFYFCGFLGILAAIISYMKLEDIVFNKNKEKIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGIYAYLALYAINY
NITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMIIIGIFIISFGMYLLSTSTTFLTILASLTIIAVGSSISSTATTS
LAVKDIPTHRKGEAMGLFTTSINIGMFIGAVSFGFLADILGIANMYKFSAIFSIVVGIISYLRIER
>Mature_385_residues
GKLEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIPVGVLSDIYGKKFFIVCGTFFY
GVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIAAIAPKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIKM
PFYFCGFLGILAAIISYMKLEDIVFNKNKEKIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGIYAYLALYAINYN
ITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMIIIGIFIISFGMYLLSTSTTFLTILASLTIIAVGSSISSTATTSL
AVKDIPTHRKGEAMGLFTTSINIGMFIGAVSFGFLADILGIANMYKFSAIFSIVVGIISYLRIER

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily

Homologues:

Organism=Escherichia coli, GI1787291, Length=291, Percent_Identity=27.1477663230241, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI2367379, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1560_METJA (Q58955)

Other databases:

- EMBL:   L77117
- PIR:   G64494
- RefSeq:   NP_248568.1
- ProteinModelPortal:   Q58955
- GeneID:   1452468
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1560
- NMPDR:   fig|243232.1.peg.1605
- TIGR:   MJ1560
- HOGENOM:   HBG541020
- OMA:   PENGWRL
- ProtClustDB:   CLSK876619
- BioCyc:   MJAN243232:MJ_1560-MONOMER
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958
- PRINTS:   PR01035

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 42069; Mature: 41938

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe67068c)-; HASH(0xe50031c)-; HASH(0xefd6b1c)-; HASH(0xb8c432c)-; HASH(0xeeea5c8)-; HASH(0xe91d334)-; HASH(0xb86bd38)-; HASH(0xe71efc8)-; HASH(0xee24d9c)-; HASH(0xeed7ce0)-; HASH(0xf05314c)-; HASH(0xee780b4)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCC
VGVLSDIYGKKFFIVCGTFFYGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIA
HHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AIAPKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIKMPFYFCGFLGILAAIISYMK
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LEDIVFNKNKEKIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGIYAYLALYAINY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
NITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMIIIGIFIISFGMYLLSTSTTFLTI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLTIIAVGSSISSTATTSLAVKDIPTHRKGEAMGLFTTSINIGMFIGAVSFGFLADIL
HHHHHHHHCCCCCCCHHHHHEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
GIANMYKFSAIFSIVVGIISYLRIER
HHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
GKLEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIP
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCC
VGVLSDIYGKKFFIVCGTFFYGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIA
HHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AIAPKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIKMPFYFCGFLGILAAIISYMK
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LEDIVFNKNKEKIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGIYAYLALYAINY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
NITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMIIIGIFIISFGMYLLSTSTTFLTI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLTIIAVGSSISSTATTSLAVKDIPTHRKGEAMGLFTTSINIGMFIGAVSFGFLADIL
HHHHHHHHCCCCCCCHHHHHEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHH
GIANMYKFSAIFSIVVGIISYLRIER
HHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087