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The map label for this gene is pyrK

Identifier: 15669637

GI number: 15669637

Start: 1414940

End: 1415713

Strand: Direct

Name: pyrK

Synonym: MJ1446

Alternate gene names: 15669637

Gene position: 1414940-1415713 (Clockwise)

Preceding gene: 15669636

Following gene: 15669638

Centisome position: 84.98

GC content: 33.33

Gene sequence:

>774_bases
ATGGAAAAACCAGTTATATGTAGAATAAAAGAAATAATAGAAGAAAGCCCAACAGTAAAAACATTTGTAGTAGATAAAGA
TTTTGATTTTAAGCCGGGACAGTTTGCAATGCTTTGGCTTCCGGGAGTTGATGAAAAACCATTTGGATTTTCTTCTAAAA
ATAGTTTTAGTGTTGCAAGAGTTGGAGAATTTACCAAAAAAATGCATGAACTAAAAGAAGGAGATATAATAGGAGTTAGA
GGGCCTTATGGAACATATTTTGAGCCAATAGGAGATAAGGTTTTGGCAGTTGCTGGAGGTATTGGAGCTGCACCAATTAT
AACAGCAGTTGAAGAATTTTCAAAGCAGGGAATTGAAATAACAACCATATTAGGGGCGAGAACTAAAGAAGAGTTATTAT
TTTTGGATAGATTTGAAAAAGTTAGCAGATTAGAGATTTGCACAGATGATGGTAGTTTTGGATTTAAAGGTTTTACAACT
GAAAAAATGAAAGAAGTCCTTAAAGAAGAGAAATTTGATTTAATTATAACTTGTGGGCCAGAAATAATGATGAAAAAGGT
TGTAGAAATAGCAAATGAATATAATATTCCAGTTCAGGTTTCAATGGAGAGGTATATGAAGTGTGGTATAGGTATTTGTG
GGCAGTGTTGTGTAGATGATGAGGGACTTTGTGTTTGTAAGGATGGGCCAGTATTTTGGGGAGATAAGTTGAAATTTATT
AGAGAATTTGGGAAGTATAAGAGAGATGCAAGCGGTAAGAAGATTTATTATTAA

Upstream 100 bases:

>100_bases
CAATAAATGATTTGTAAAAGTATTTAATAAATTTAAGTTTTTAGTTTTTATTATTTTATTTTTAGTTTTTAATAGAAAAT
TTTATAATTCAGGTGATATT

Downstream 100 bases:

>100_bases
CATTATAAGGTATTGATATTTAGTTTTGATCAACCTTTTCTAAAAAGGTTGTTCGGGGAGTATATAGAGATGCGAGTGGA
AAATTGTTAAATTTTAAATA

Product: dihydroorotate dehydrogenase electron transfer subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MEKPVICRIKEIIEESPTVKTFVVDKDFDFKPGQFAMLWLPGVDEKPFGFSSKNSFSVARVGEFTKKMHELKEGDIIGVR
GPYGTYFEPIGDKVLAVAGGIGAAPIITAVEEFSKQGIEITTILGARTKEELLFLDRFEKVSRLEICTDDGSFGFKGFTT
EKMKEVLKEEKFDLIITCGPEIMMKKVVEIANEYNIPVQVSMERYMKCGIGICGQCCVDDEGLCVCKDGPVFWGDKLKFI
REFGKYKRDASGKKIYY

Sequences:

>Translated_257_residues
MEKPVICRIKEIIEESPTVKTFVVDKDFDFKPGQFAMLWLPGVDEKPFGFSSKNSFSVARVGEFTKKMHELKEGDIIGVR
GPYGTYFEPIGDKVLAVAGGIGAAPIITAVEEFSKQGIEITTILGARTKEELLFLDRFEKVSRLEICTDDGSFGFKGFTT
EKMKEVLKEEKFDLIITCGPEIMMKKVVEIANEYNIPVQVSMERYMKCGIGICGQCCVDDEGLCVCKDGPVFWGDKLKFI
REFGKYKRDASGKKIYY
>Mature_257_residues
MEKPVICRIKEIIEESPTVKTFVVDKDFDFKPGQFAMLWLPGVDEKPFGFSSKNSFSVARVGEFTKKMHELKEGDIIGVR
GPYGTYFEPIGDKVLAVAGGIGAAPIITAVEEFSKQGIEITTILGARTKEELLFLDRFEKVSRLEICTDDGSFGFKGFTT
EKMKEVLKEEKFDLIITCGPEIMMKKVVEIANEYNIPVQVSMERYMKCGIGICGQCCVDDEGLCVCKDGPVFWGDKLKFI
REFGKYKRDASGKKIYY

Specific function: Is responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+)

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRK_METJA (Q58841)

Other databases:

- EMBL:   L77117
- PIR:   E64480
- RefSeq:   NP_248450.1
- ProteinModelPortal:   Q58841
- SMR:   Q58841
- GeneID:   1452350
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1446
- NMPDR:   fig|243232.1.peg.1487
- TIGR:   MJ1446
- HOGENOM:   HBG730970
- OMA:   RYMKCGI
- ProtClustDB:   PRK00054
- BioCyc:   MJAN243232:MJ_1446-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01211_A
- InterPro:   IPR012165
- InterPro:   IPR019480
- InterPro:   IPR017927
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938
- PIRSF:   PIRSF006816

Pfam domain/function: PF10418 DHODB_Fe-S_bind; PF00970 FAD_binding_6; PF00175 NAD_binding_1; SSF63380 Riboflavin_synthase_like_b-brl

EC number: NA

Molecular weight: Translated: 28908; Mature: 28908

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00197 2FE2S_FER_1; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPVICRIKEIIEESPTVKTFVVDKDFDFKPGQFAMLWLPGVDEKPFGFSSKNSFSVAR
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
VGEFTKKMHELKEGDIIGVRGPYGTYFEPIGDKVLAVAGGIGAAPIITAVEEFSKQGIEI
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEE
TTILGARTKEELLFLDRFEKVSRLEICTDDGSFGFKGFTTEKMKEVLKEEKFDLIITCGP
EEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCH
EIMMKKVVEIANEYNIPVQVSMERYMKCGIGICGQCCVDDEGLCVCKDGPVFWGDKLKFI
HHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCCEEECCCCEEEECCCCEEECHHHHHH
REFGKYKRDASGKKIYY
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEKPVICRIKEIIEESPTVKTFVVDKDFDFKPGQFAMLWLPGVDEKPFGFSSKNSFSVAR
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
VGEFTKKMHELKEGDIIGVRGPYGTYFEPIGDKVLAVAGGIGAAPIITAVEEFSKQGIEI
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEE
TTILGARTKEELLFLDRFEKVSRLEICTDDGSFGFKGFTTEKMKEVLKEEKFDLIITCGP
EEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCH
EIMMKKVVEIANEYNIPVQVSMERYMKCGIGICGQCCVDDEGLCVCKDGPVFWGDKLKFI
HHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCCEEECCCCEEEECCCCEEECHHHHHH
REFGKYKRDASGKKIYY
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087