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The map label for this gene is uppS

Identifier: 15669562

GI number: 15669562

Start: 1320757

End: 1321599

Strand: Direct

Name: uppS

Synonym: MJ1372

Alternate gene names: 15669562

Gene position: 1320757-1321599 (Clockwise)

Preceding gene: 15669561

Following gene: 15669563

Centisome position: 79.33

GC content: 31.55

Gene sequence:

>843_bases
GTGGGGATTTTGGGTAAGATAAAAAACAAATTAAAGAGTATTGGAAAAAGAGTAATAATTGATTTTTATAGATTTTTAGA
CAACTCCGGAGTTTTAAAAATTTACGAGAAGATTTTAGAAGAGGCTATTGATAAAGACAATTTACCAAAACATGTAGCTA
TAATAATGGATGGAAATAGAAGGGCTGCAGAGATTTATGGAAAAGATAGATACTACGGGCATTACTTGGGGGCTGAGAAG
GTTAGAGAAGTCTTAAGATGGGCAAGGGATTTGGGCATAAATGTTGTTACTCTATATGCCTTTTCTACTGAAAATTTTAG
AAGACCTAAGGAAGAAGTTGATAAATTAATGGAATTATTTGAAAAAAAGTTTTACGAGATTGCAGATGATGAAGAAATTC
ATAGATATGAAGTTAGAGTTAGAGCAATTGGTAGAATTAATCTATTGCCAAAAAATGTTCAAAAAGCAATAAAATACGCT
GAAGAGAGAACAAAAAACTACAACAAATTTTTTGTTAATATTGCAATAGCTTATGGAGGACAGCAAGAAATAATAGATGC
TGTAAAAAAGATAGCTGAAAAGGTTAAAAGAGGAGAAATAGAACCAGAAGATATTGATAAAGAGTTAATAGATAAACATT
TATACACAGCAAATTTGCCATTTCCAAATCCTGATTTGATTATCAGAACTTCTGGGGAGGAAAGAATTAGTAATTTTTTA
ATTTGGCAGAGCTCTTATTCAGAGCTGTATTTTTGTGATATATATTGGCCGTTATTTAGAAGAGTGGATTTTCTAAGGGC
GGTTAGAGATTACCAAAGAAGACAGCGGAGGTTTGGAAAATGA

Upstream 100 bases:

>100_bases
TATGGGGCAGTTATTTTATCAGATAAAAATGTCAATTTTATTGATACAAGTAGAAACGCTAATTGGGAGAGATACTATAA
CGCTATTAAATTCCTAATAG

Downstream 100 bases:

>100_bases
AAAAGAAAATAATTATATTGTTTCTATTTACTGCTATTCTTTGTTCTATAACTTTATGTGGTTGTATCTCTTTTGAAAAA
ACCCAAATAGGCAATTATAA

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MGILGKIKNKLKSIGKRVIIDFYRFLDNSGVLKIYEKILEEAIDKDNLPKHVAIIMDGNRRAAEIYGKDRYYGHYLGAEK
VREVLRWARDLGINVVTLYAFSTENFRRPKEEVDKLMELFEKKFYEIADDEEIHRYEVRVRAIGRINLLPKNVQKAIKYA
EERTKNYNKFFVNIAIAYGGQQEIIDAVKKIAEKVKRGEIEPEDIDKELIDKHLYTANLPFPNPDLIIRTSGEERISNFL
IWQSSYSELYFCDIYWPLFRRVDFLRAVRDYQRRQRRFGK

Sequences:

>Translated_280_residues
MGILGKIKNKLKSIGKRVIIDFYRFLDNSGVLKIYEKILEEAIDKDNLPKHVAIIMDGNRRAAEIYGKDRYYGHYLGAEK
VREVLRWARDLGINVVTLYAFSTENFRRPKEEVDKLMELFEKKFYEIADDEEIHRYEVRVRAIGRINLLPKNVQKAIKYA
EERTKNYNKFFVNIAIAYGGQQEIIDAVKKIAEKVKRGEIEPEDIDKELIDKHLYTANLPFPNPDLIIRTSGEERISNFL
IWQSSYSELYFCDIYWPLFRRVDFLRAVRDYQRRQRRFGK
>Mature_279_residues
GILGKIKNKLKSIGKRVIIDFYRFLDNSGVLKIYEKILEEAIDKDNLPKHVAIIMDGNRRAAEIYGKDRYYGHYLGAEKV
REVLRWARDLGINVVTLYAFSTENFRRPKEEVDKLMELFEKKFYEIADDEEIHRYEVRVRAIGRINLLPKNVQKAIKYAE
ERTKNYNKFFVNIAIAYGGQQEIIDAVKKIAEKVKRGEIEPEDIDKELIDKHLYTANLPFPNPDLIIRTSGEERISNFLI
WQSSYSELYFCDIYWPLFRRVDFLRAVRDYQRRQRRFGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=244, Percent_Identity=43.4426229508197, Blast_Score=214, Evalue=5e-56,
Organism=Homo sapiens, GI45580742, Length=244, Percent_Identity=43.4426229508197, Blast_Score=214, Evalue=5e-56,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=44.5887445887446, Blast_Score=203, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71993029, Length=240, Percent_Identity=36.25, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319474, Length=236, Percent_Identity=37.2881355932203, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=32.7510917030568, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=41.4096916299559, Blast_Score=179, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_METJA (Q58767)

Other databases:

- EMBL:   L77117
- PIR:   C64471
- RefSeq:   NP_248375.1
- ProteinModelPortal:   Q58767
- SMR:   Q58767
- GeneID:   1452275
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1372
- NMPDR:   fig|243232.1.peg.1412
- TIGR:   MJ1372
- HOGENOM:   HBG627837
- OMA:   YGGQQEI
- ProtClustDB:   CLSK876552
- BioCyc:   MJAN243232:MJ_1372-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 33287; Mature: 33156

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 57-57

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILGKIKNKLKSIGKRVIIDFYRFLDNSGVLKIYEKILEEAIDKDNLPKHVAIIMDGNR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RAAEIYGKDRYYGHYLGAEKVREVLRWARDLGINVVTLYAFSTENFRRPKEEVDKLMELF
CEEHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCHHCCCHHHHHHHHHHH
EKKFYEIADDEEIHRYEVRVRAIGRINLLPKNVQKAIKYAEERTKNYNKFFVNIAIAYGG
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECC
QQEIIDAVKKIAEKVKRGEIEPEDIDKELIDKHLYTANLPFPNPDLIIRTSGEERISNFL
HHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHEECCCCCCCCCEEEECCCHHHHHHHE
IWQSSYSELYFCDIYWPLFRRVDFLRAVRDYQRRQRRFGK
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GILGKIKNKLKSIGKRVIIDFYRFLDNSGVLKIYEKILEEAIDKDNLPKHVAIIMDGNR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RAAEIYGKDRYYGHYLGAEKVREVLRWARDLGINVVTLYAFSTENFRRPKEEVDKLMELF
CEEHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCHHCCCHHHHHHHHHHH
EKKFYEIADDEEIHRYEVRVRAIGRINLLPKNVQKAIKYAEERTKNYNKFFVNIAIAYGG
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECC
QQEIIDAVKKIAEKVKRGEIEPEDIDKELIDKHLYTANLPFPNPDLIIRTSGEERISNFL
HHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHEECCCCCCCCCEEEECCCHHHHHHHE
IWQSSYSELYFCDIYWPLFRRVDFLRAVRDYQRRQRRFGK
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087