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The map label for this gene is sucD

Identifier: 15669431

GI number: 15669431

Start: 1188906

End: 1189790

Strand: Reverse

Name: sucD

Synonym: MJ1246

Alternate gene names: 15669431

Gene position: 1189790-1188906 (Counterclockwise)

Preceding gene: 15669433

Following gene: 15669430

Centisome position: 71.46

GC content: 38.98

Gene sequence:

>885_bases
ATGGTGTTGAGGGATAAAATGATATTATTGGATGAGAACACAAAGGCGATAGTTCAGGGAATTACTGGAAGGCAGGGAAG
TTTTCACACAAAGAAAATGTTAGAATGTGGAACTAAAATTGTTGGAGGAGTCACACCAGGAAAAGGAGGGCAGAACGTCC
ATGGAGTTCCTGTTTTTGATACAGTTAAAGAGGCAGTTAAAGAGACAGATGCCAATGCGTCAGTAATTTTTGTTCCAGCT
CCATTTGCTAAAGATGCAGTTTTTGAGGCAATAGATGCCGGAATTGAGTTGATAGTTGTTATTACAGAGCATATCCCAGT
TCATGATACTATGGAGTTCGTAAATTACGCTGAAGATGTTGGAGTGAAGATTATAGGGCCGAATACACCAGGTATAGCAT
CACCAAAAGTTGGCAAGCTTGGAATTATACCAATGGAAGTTTTAAAAGAGGGAAGTGTAGGGATGGTTTCAAGAAGTGGA
ACTTTAACTTATGAGATAGCTCACCAAATAAAAAAGGCTGGTTTTGGAGTTTCAACTTGCGTAGGGATTGGAGGAGACCC
AATAGTTGGATTAAGATATAAGGAGGTTTTAGATTTATTTGAGAAGGATGATGAGACAGAAGCTATTGTTATGATTGGAG
AGATTGGTGGAGGGGCTGAAGAAGAGGCAGCTAAATTTATAGAGAAGATGAAAAAACCAGTTATTGGTTATATAGCTGGA
CAATCAGCACCAGAAGGAAAGAGAATGGGACATGCTGGAGCTATTGTTGAGAAAGGAAAAGGAACAGCAGAAAGTAAGAT
GAAGGCTTTAGAAGAGGCAGGTGCTTATGTGGCAAAAAATATATCTGATATTCCAAAGTTATTGGCAGGGATTTTAGGAA
AATAA

Upstream 100 bases:

>100_bases
TTTAGGCATCAAAGTGCCTTATAAATATATAAATTGTGAAAGTTCTACAACGACACATATAAAAAGTAAAAGGGGATATA
TAAATTTTACGGTTTAATAC

Downstream 100 bases:

>100_bases
TATCCTATTATTTAAAAATTTGAAAATTATAATACGATAATTGTTAAAATTTCTTTTTTTAATAACATATTAAGGAAACT
AAATGAAAAACTTTATATTC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFDTVKEAVKETDANASVIFVPA
PFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDVGVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSG
TLTYEIAHQIKKAGFGVSTCVGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAG
QSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK

Sequences:

>Translated_294_residues
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFDTVKEAVKETDANASVIFVPA
PFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDVGVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSG
TLTYEIAHQIKKAGFGVSTCVGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAG
QSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK
>Mature_294_residues
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFDTVKEAVKETDANASVIFVPA
PFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDVGVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSG
TLTYEIAHQIKKAGFGVSTCVGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAG
QSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=279, Percent_Identity=51.9713261648746, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI38569421, Length=309, Percent_Identity=29.126213592233, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI38569423, Length=309, Percent_Identity=29.126213592233, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786949, Length=286, Percent_Identity=58.7412587412587, Blast_Score=326, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI17550194, Length=292, Percent_Identity=49.6575342465753, Blast_Score=253, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17553126, Length=276, Percent_Identity=49.6376811594203, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17557344, Length=302, Percent_Identity=29.8013245033113, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=302, Percent_Identity=28.476821192053, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=285, Percent_Identity=45.6140350877193, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21356559, Length=279, Percent_Identity=49.4623655913978, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI28574296, Length=278, Percent_Identity=50, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI281363477, Length=316, Percent_Identity=28.7974683544304, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281363475, Length=316, Percent_Identity=28.7974683544304, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281363473, Length=316, Percent_Identity=28.7974683544304, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_METJA (Q58643)

Other databases:

- EMBL:   L77117
- PIR:   E64455
- RefSeq:   NP_248241.1
- PDB:   2YV1
- PDBsum:   2YV1
- ProteinModelPortal:   Q58643
- SMR:   Q58643
- GeneID:   1452142
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1246
- NMPDR:   fig|243232.1.peg.1278
- TIGR:   MJ1246
- HOGENOM:   HBG615372
- OMA:   ANDMVAT
- ProtClustDB:   PRK05678
- BioCyc:   MJAN243232:MJ_1246-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 30923; Mature: 30923

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 251-251

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFD
CCCCCCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHH
TVKEAVKETDANASVIFVPAPFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDV
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHC
GVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSGTLTYEIAHQIKKAGFGVSTC
CEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHE
VGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAG
ECCCCCCEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEC
QSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFD
CCCCCCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHH
TVKEAVKETDANASVIFVPAPFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDV
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHC
GVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSGTLTYEIAHQIKKAGFGVSTC
CEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHE
VGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAG
ECCCCCCEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEC
QSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087