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The map label for this gene is guaAB

Identifier: 15669318

GI number: 15669318

Start: 1072091

End: 1073023

Strand: Reverse

Name: guaAB

Synonym: MJ1131

Alternate gene names: 15669318

Gene position: 1073023-1072091 (Counterclockwise)

Preceding gene: 15669319

Following gene: 15669317

Centisome position: 64.45

GC content: 37.62

Gene sequence:

>933_bases
ATGTTTGACCCAAAAAAATTTATTGATGAGGCAGTAGAAGAAATAAAACAGCAAATTAGTGACAGAAAAGCAATAATTGC
CTTAAGTGGAGGGGTAGATAGCTCCGTCGCTGCCGTCTTAACCCACAAAGCAATTGGAGATAAATTAACAGCTGTTTTTG
TTGATACTGGATTGATGAGAAAGGGAGAGAGGGAAGAAGTTGAAAAAACTTTTAGAGACAAGTTGGGATTAAACTTAATT
GTTGTAGATGCAAAGGATAGATTTTTAAATGCCCTAAAAGGAGTTACAGACCCAGAGGAGAAGAGAAAGATTATTGGAAA
GTTATTTATTGATGTCTTTGAGGAGATTGCTGAAGATATAAAGGCAGAGGTTTTAGTGCAAGGGACTATAGCCCCAGATT
GGATTGAAACACAAGGGAAGATAAAGAGCCATCATAACGTTGCCCTACCTCACGGAATGGTTTTAGAGGTTGTTGAACCA
TTGAGAGAGCTTTATAAAGATGAAGTTAGATTGTTGGCAAAAGAATTAGGGCTACCAGATAGCATCGTCTATAGACAACC
ATTCCCAGGGCCAGGATTAGCTGTTAGAGTTTTAGGGGAGGTTACAGAAGAAAAGCTAAACATCTGCAGAGAGGCAAATG
CAATAGTTGAGGAAGAAGTTAAAAAAGCCAACTTAGATAAAGATTTATGGCAATACTTTGCCGTTGTTTTGGACTGTAAA
GCAACTGGAGTTAAGGGAGATGAAAGGGAATACAACTGGATTGTCGCCTTAAGAATGGTTAAATCATTGGATGCTATGAC
AGCACACGTTCCAGAGATTCCTTTTGATTTGTTGAAGAGGATTAGTAAAAGAATTACATCAGAAATTCCAAATGTTGCAA
GAGTAGTGTTTGATATAACTGATAAGCCACCAGCTACAATTGAATTTGAATAA

Upstream 100 bases:

>100_bases
ACATTTAAACAGTTGTAAGAAAAACATTATTATATTAGAAGAAAATGAAAATAACGGTGAAAGTGCTGAAAAGGAAGAAT
AATTTAAAGGTGATATTTTT

Downstream 100 bases:

>100_bases
AAAAACTTTTTTAAACTTTTTTAGTTTATTATATTGACATTAACTATTTAACTATTTTGGCAATTTAAATATTATAATAG
TATAATTGAGTGATAATATG

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MFDPKKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMRKGEREEVEKTFRDKLGLNLI
VVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDIKAEVLVQGTIAPDWIETQGKIKSHHNVALPHGMVLEVVEP
LRELYKDEVRLLAKELGLPDSIVYRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCK
ATGVKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDITDKPPATIEFE

Sequences:

>Translated_310_residues
MFDPKKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMRKGEREEVEKTFRDKLGLNLI
VVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDIKAEVLVQGTIAPDWIETQGKIKSHHNVALPHGMVLEVVEP
LRELYKDEVRLLAKELGLPDSIVYRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCK
ATGVKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDITDKPPATIEFE
>Mature_310_residues
MFDPKKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMRKGEREEVEKTFRDKLGLNLI
VVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDIKAEVLVQGTIAPDWIETQGKIKSHHNVALPHGMVLEVVEP
LRELYKDEVRLLAKELGLPDSIVYRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCK
ATGVKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDITDKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=312, Percent_Identity=34.6153846153846, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788854, Length=321, Percent_Identity=53.2710280373832, Blast_Score=330, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI71992717, Length=368, Percent_Identity=33.695652173913, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71992710, Length=368, Percent_Identity=33.695652173913, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI133901714, Length=368, Percent_Identity=33.695652173913, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323873, Length=320, Percent_Identity=49.0625, Blast_Score=292, Evalue=4e-80,
Organism=Drosophila melanogaster, GI281365319, Length=310, Percent_Identity=34.5161290322581, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_METJA (Q58531)

Other databases:

- EMBL:   L77117
- PIR:   B64441
- RefSeq:   NP_248123.1
- ProteinModelPortal:   Q58531
- SMR:   Q58531
- GeneID:   1452027
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1131
- NMPDR:   fig|243232.1.peg.1160
- TIGR:   MJ1131
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   PRK00919
- BioCyc:   MJAN243232:MJ_1131-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 34807; Mature: 34807

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDPKKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGEREEVEKTFRDKLGLNLIVVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDI
CCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KAEVLVQGTIAPDWIETQGKIKSHHNVALPHGMVLEVVEPLRELYKDEVRLLAKELGLPD
HHHEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIVYRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCK
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATGVKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
DKPPATIEFE
CCCCCEEECC
>Mature Secondary Structure
MFDPKKFIDEAVEEIKQQISDRKAIIALSGGVDSSVAAVLTHKAIGDKLTAVFVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGEREEVEKTFRDKLGLNLIVVDAKDRFLNALKGVTDPEEKRKIIGKLFIDVFEEIAEDI
CCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KAEVLVQGTIAPDWIETQGKIKSHHNVALPHGMVLEVVEPLRELYKDEVRLLAKELGLPD
HHHEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SIVYRQPFPGPGLAVRVLGEVTEEKLNICREANAIVEEEVKKANLDKDLWQYFAVVLDCK
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATGVKGDEREYNWIVALRMVKSLDAMTAHVPEIPFDLLKRISKRITSEIPNVARVVFDIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
DKPPATIEFE
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087