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The map label for this gene is gcp

Identifier: 15669317

GI number: 15669317

Start: 1070386

End: 1071993

Strand: Reverse

Name: gcp

Synonym: MJ1130

Alternate gene names: 15669317

Gene position: 1071993-1070386 (Counterclockwise)

Preceding gene: 15669318

Following gene: 15669316

Centisome position: 64.39

GC content: 35.95

Gene sequence:

>1608_bases
ATGATTTGCTTAGGATTAGAAGGAACTGCAGAAAAAACTGGGGTAGGGATTGTTACCTCTGATGGAGAGGTTTTATTTAA
TAAAACTATCATGTATAAACCCCCAAAACAGGGTATTAATCCAAGAGAGGCTGCTGACCATCATGCTGAAACATTTCCTA
AGCTTATAAAAGAGGCTTTTGAAGTAGTTGATAAAAATGAGATTGATTTAATTGCATTCTCCCAAGGGCCGGGATTAGGG
CCGAGTTTGAGGGTAACTGCAACCGTAGCAAGAACTTTATCTTTAACATTAAAAAAACCAATAATTGGGGTTAATCATTG
CATTGCCCATATAGAGATTGGTAAGCTAACTACAGAGGCAGAAGACCCTCTAACTCTATATGTTAGTGGTGGAAACACCC
AAGTTATAGCTTATGTCTCAAAAAAATATAGGGTATTTGGAGAGACGTTAGATATAGCTGTTGGTAACTGCTTAGACCAG
TTTGCAAGATATGTGAATTTGCCACATCCCGGGGGGCCTTATATAGAGGAATTGGCAAGGAAAGGGAAAAAGCTTGTTGA
TTTACCTTACACTGTTAAAGGCATGGATATAGCATTCTCTGGATTGCTAACAGCGGCTATGAGAGCTTATGATGCTGGAG
AGAGATTGGAAGATATCTGCTACTCCCTACAAGAATATGCCTTCTCAATGCTAACTGAGATTACAGAAAGGGCTTTAGCT
CACACAAATAAAGGAGAGGTCATGCTCGTTGGTGGAGTAGCGGCAAATAACAGATTGAGAGAGATGCTCAAAGCTATGTG
TGAGGGTCAGAATGTTGATTTTTACGTCCCTCCTAAGGAGTTTTGTGGAGACAATGGAGCTATGATTGCATGGCTTGGTT
TATTGATGCATAAAAATGGAAGATGGATGAGTTTGGATGAAACAAAGATAATTCCAAATTATAGGACTGATATGGTTGAA
GTTAATTGGATAAAAGAAATTAAAGGCAAGAAGAGAAAGATTCCAGAACATTTAATTGGTAAGGGGGCAGAGGCAGATAT
TAAGAGAGATAGCTATTTAGATTTTGATGTAATTATTAAGGAGAGAGTTAAAAAAGGCTATAGGGATGAGAGATTAGATG
AAAATATAAGAAAGAGTAGAACTGCAAGAGAGGCAAGGTATTTAGCATTGGTTAAAGATTTTGGTATCCCAGCTCCATAC
ATATTTGATGTTGATTTAGATAACAAGAGAATTATGATGAGTTATATCAACGGAAAGTTAGCTAAGGATGTTATTGAGGA
TAATTTAGATATTGCATACAAAATTGGAGAAATCGTTGGAAAACTGCATAAAAACGATGTAATTCATAATGACTTAACTA
CATCCAACTTTATATTTGATAAAGATTTATATATCATTGATTTTGGTTTAGGAAAGATTTCAAATCTTGATGAAGATAAG
GCAGTTGATTTAATCGTCTTTAAAAAGGCTGTGTTATCAACTCATCATGAAAAGTTTGATGAAATCTGGGAGAGATTTTT
AGAGGGTTATAAAAGTGTTTATGATAGGTGGGAGATTATACTGGAGTTAATGAAGGATGTTGAAAGAAGAGCAAGATATG
TAGAGTAA

Upstream 100 bases:

>100_bases
TAAAAAAACTTTTTTAAACTTTTTTAGTTTATTATATTGACATTAACTATTTAACTATTTTGGCAATTTAAATATTATAA
TAGTATAATTGAGTGATAAT

Downstream 100 bases:

>100_bases
ATATTTAAAATTTTTTAAGTGGTATGATTTTTCCACTTATGAGTAAAAAAAATGTAAAAATAGAAGTATTTATATAATGA
GCAAATACTAAAAAATTATT

Product: O-sialoglycoprotein endopeptidase/protein kinase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAFEVVDKNEIDLIAFSQGPGLG
PSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQ
FARYVNLPHPGGPYIEELARKGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALA
HTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMSLDETKIIPNYRTDMVE
VNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPY
IFDVDLDNKRIMMSYINGKLAKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDK
AVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE

Sequences:

>Translated_535_residues
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAFEVVDKNEIDLIAFSQGPGLG
PSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQ
FARYVNLPHPGGPYIEELARKGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALA
HTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMSLDETKIIPNYRTDMVE
VNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPY
IFDVDLDNKRIMMSYINGKLAKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDK
AVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE
>Mature_535_residues
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAFEVVDKNEIDLIAFSQGPGLG
PSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQ
FARYVNLPHPGGPYIEELARKGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALA
HTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMSLDETKIIPNYRTDMVE
VNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPY
IFDVDLDNKRIMMSYINGKLAKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDK
AVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI8923380, Length=331, Percent_Identity=50.4531722054381, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI41327715, Length=211, Percent_Identity=35.5450236966825, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI116812636, Length=332, Percent_Identity=29.8192771084337, Blast_Score=116, Evalue=7e-26,
Organism=Escherichia coli, GI1789445, Length=322, Percent_Identity=32.6086956521739, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71995670, Length=336, Percent_Identity=51.4880952380952, Blast_Score=337, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI17557464, Length=328, Percent_Identity=25.609756097561, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322891, Length=368, Percent_Identity=45.3804347826087, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6320099, Length=352, Percent_Identity=27.5568181818182, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321701, Length=213, Percent_Identity=32.8638497652582, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357207, Length=346, Percent_Identity=46.8208092485549, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24658177, Length=215, Percent_Identity=34.4186046511628, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20129063, Length=338, Percent_Identity=27.2189349112426, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_METJA (Q58530)

Other databases:

- EMBL:   L77117
- RefSeq:   NP_248122.1
- PDB:   2VWB
- PDB:   3EN9
- PDB:   3ENH
- PDBsum:   2VWB
- PDBsum:   3EN9
- PDBsum:   3ENH
- ProteinModelPortal:   Q58530
- MEROPS:   M22.003
- GeneID:   1452026
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1130
- NMPDR:   fig|243232.1.peg.1159
- TIGR:   MJ1130
- HOGENOM:   HBG304663
- OMA:   GNCLDQF
- ProtClustDB:   PRK09605
- BioCyc:   MJAN243232:MJ_1130-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01447
- InterPro:   IPR022449
- InterPro:   IPR022495
- InterPro:   IPR011009
- InterPro:   IPR009220
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR008266
- PANTHER:   PTHR11735
- PIRSF:   PIRSF036401
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03724
- TIGRFAMs:   TIGR03722
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22; PF00069 Pkinase; SSF56112 Kinase_like

EC number: =3.4.24.57

Molecular weight: Translated: 60571; Mature: 60571

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01016 GLYCOPROTEASE; PS50011 PROTEIN_KINASE_DOM; PS00109 PROTEIN_KINASE_TYR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAF
CEEECCCCCCCCCCEEEEECCCCEEEECEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVVDKNEIDLIAFSQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEA
HHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHEEEEECCEECCC
EDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQFARYVNLPHPGGPYIEELAR
CCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALA
CCCEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNG
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHHHHHHHCCCC
RWMSLDETKIIPNYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIK
CEEECCCCCCCCCCCCCEEEEHHHHHHCCHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHH
ERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHCCHH
AKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDK
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCH
AVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MICLGLEGTAEKTGVGIVTSDGEVLFNKTIMYKPPKQGINPREAADHHAETFPKLIKEAF
CEEECCCCCCCCCCEEEEECCCCEEEECEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVVDKNEIDLIAFSQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTEA
HHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHEEEEECCEECCC
EDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAVGNCLDQFARYVNLPHPGGPYIEELAR
CCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGKKLVDLPYTVKGMDIAFSGLLTAAMRAYDAGERLEDICYSLQEYAFSMLTEITERALA
CCCEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTNKGEVMLVGGVAANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNG
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHHHHHHHCCCC
RWMSLDETKIIPNYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIK
CEEECCCCCCCCCCCCCEEEEHHHHHHCCHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHH
ERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHCCHH
AKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLYIIDFGLGKISNLDEDK
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCH
AVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEIILELMKDVERRARYVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087