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The map label for this gene is serS

Identifier: 15669265

GI number: 15669265

Start: 1016678

End: 1018243

Strand: Reverse

Name: serS

Synonym: MJ1077

Alternate gene names: 15669265

Gene position: 1018243-1016678 (Counterclockwise)

Preceding gene: 15669266

Following gene: 15669264

Centisome position: 61.16

GC content: 34.61

Gene sequence:

>1566_bases
ATGAAACTCACATTTGATTTAGATGGGAAGATAATATTTAGTAAAGAGTTAAGTGAGGAGGCAAAAAATGCTGTAGAGGA
AGTTTTAAAAAATGCAGACAGCATATTCTTAAAAGGTGTTCCAAAGGGTAAAGAAAATGAGGCATCAAAAATAAAAAGCT
ATGAGTTTGAAGGAAACATTTTAAAATTAAAAATTGCCTCTGGAACTTACACAAGAGCTCATGAAGGATTAATTAGATTG
AGAAAGCCGTTAGCTGAAAAATTGGGAAGAAACTTTAGAATTGGAGTTAGAGGAATTGAGATAGATAATTATGTAATAAC
AATTGAAACAGATGAAGATAAAGCTAAAAAATTAGAAGGCATTAAAGTTCCAGAGTGTGAGGCAAAAGTTGAAGGAAACA
AAATTATCTTAACTTTTAAGGACATTGGAGAGAGTGAATTAAAAAGAAACATTATAGATAGAGCAATAAAGTTCGTAAAA
ACAGAGTTGGAGAAAGAAGAAGAGGATTTAACATTCAAAGTTTGTAAAATTCCACCTGGAACAATAGTTAGTGAATATAA
GGCAAAGAGAAAAATAACATTTGATAAAGACCCAACAGATGTTGCTGAAAAACTTGGATGGGTTAAAAAATTCCCAGGAA
GAGGACAGTGGTTCTATACTCCACCAATAACAGCATTGTTTAGAGCTTTAGAGGAGTTAATAGTTGAAGAAGTTGTTAAA
AAGATTGGATTTCAAGAATGCCTATTCCCAAAACTCATTCCATTGGAGATTATGTATAAGATGAGATATTTAGAGGGCTT
ACCAGAGGGAATGTATTACGTATGCCCACCAAAGAGGGAGCCAGAGCTTTTTAAAGAGTTTGTAAATGAGATGATGATTA
AAAAAGAGATTCCAATTGAAAAATTAAAAAATCTATTGAGAGATCCAGGTTATGTGTTAGCCCCAGCTCAGTGTGAGCCG
TTCTATCAATTCTTTGAGGGAGAGGTTATTGATGTTGATAAACCAATAATGTTCTTTGATAGAAGTGGATGGACTTATAG
ATGGGAAGGAGGAGGGGCAAGAGGTTTAGACAGAGTTAATGAATTCTTGAGGGTTGAGTGTGTTTGGATTGGAAGTCCAG
AGTTTGTTGAAGAAACAAGAGACAAAACATTAAAATATGCTGAAAAATTAGCTGAAAAGCTTGATTTAGAGTATTGGGTT
GAGGTTGGAGATGACCCATTCTATTTGGAGGGTAGAAAAAAGGAGGATAGAGGAATAGAATTCCCAGACGTGCCAAAGTA
TGAGATGAGGTTGTGGTTACCGCATATAAAAGATGAGAGGAAGGGAGTTGCTGTTACATCAGCGAATGTGCATGGAACAC
ACTTCGTTGAGGGCTTTAGAATTAAAGATTATAAAGGAAGAAGAGTTTGGACTGGTTGTACTGGATATGGAATAACAAGA
TGGGTTGTTGGTTATTTAGCTCAATATGGATTTAATTTTGATGACTGGCATCCAATAATAAAGAAGAAGATTAAAAAGCT
TCCAGAAGTTCCTCAATTGATAACTTGGCCTAAGAAGGATGAATAA

Upstream 100 bases:

>100_bases
AGAAATATTAAATTAAACTGTATTTCTAAAAACACAATAAAAAACATAAATACCTAATTATCAATTCAATAAAAACAATA
AGAGTGTTATTGGTGATAAA

Downstream 100 bases:

>100_bases
ATTTCTTTAATTTTTTAACCTTTTGGTGATAATATGAGATTTTATAATAGGGAGAAAGAACTTAACTATCTAAAGAATTA
TGTTCAATTAGAACCAAACT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MKLTFDLDGKIIFSKELSEEAKNAVEEVLKNADSIFLKGVPKGKENEASKIKSYEFEGNILKLKIASGTYTRAHEGLIRL
RKPLAEKLGRNFRIGVRGIEIDNYVITIETDEDKAKKLEGIKVPECEAKVEGNKIILTFKDIGESELKRNIIDRAIKFVK
TELEKEEEDLTFKVCKIPPGTIVSEYKAKRKITFDKDPTDVAEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVK
KIGFQECLFPKLIPLEIMYKMRYLEGLPEGMYYVCPPKREPELFKEFVNEMMIKKEIPIEKLKNLLRDPGYVLAPAQCEP
FYQFFEGEVIDVDKPIMFFDRSGWTYRWEGGGARGLDRVNEFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWV
EVGDDPFYLEGRKKEDRGIEFPDVPKYEMRLWLPHIKDERKGVAVTSANVHGTHFVEGFRIKDYKGRRVWTGCTGYGITR
WVVGYLAQYGFNFDDWHPIIKKKIKKLPEVPQLITWPKKDE

Sequences:

>Translated_521_residues
MKLTFDLDGKIIFSKELSEEAKNAVEEVLKNADSIFLKGVPKGKENEASKIKSYEFEGNILKLKIASGTYTRAHEGLIRL
RKPLAEKLGRNFRIGVRGIEIDNYVITIETDEDKAKKLEGIKVPECEAKVEGNKIILTFKDIGESELKRNIIDRAIKFVK
TELEKEEEDLTFKVCKIPPGTIVSEYKAKRKITFDKDPTDVAEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVK
KIGFQECLFPKLIPLEIMYKMRYLEGLPEGMYYVCPPKREPELFKEFVNEMMIKKEIPIEKLKNLLRDPGYVLAPAQCEP
FYQFFEGEVIDVDKPIMFFDRSGWTYRWEGGGARGLDRVNEFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWV
EVGDDPFYLEGRKKEDRGIEFPDVPKYEMRLWLPHIKDERKGVAVTSANVHGTHFVEGFRIKDYKGRRVWTGCTGYGITR
WVVGYLAQYGFNFDDWHPIIKKKIKKLPEVPQLITWPKKDE
>Mature_521_residues
MKLTFDLDGKIIFSKELSEEAKNAVEEVLKNADSIFLKGVPKGKENEASKIKSYEFEGNILKLKIASGTYTRAHEGLIRL
RKPLAEKLGRNFRIGVRGIEIDNYVITIETDEDKAKKLEGIKVPECEAKVEGNKIILTFKDIGESELKRNIIDRAIKFVK
TELEKEEEDLTFKVCKIPPGTIVSEYKAKRKITFDKDPTDVAEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVK
KIGFQECLFPKLIPLEIMYKMRYLEGLPEGMYYVCPPKREPELFKEFVNEMMIKKEIPIEKLKNLLRDPGYVLAPAQCEP
FYQFFEGEVIDVDKPIMFFDRSGWTYRWEGGGARGLDRVNEFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWV
EVGDDPFYLEGRKKEDRGIEFPDVPKYEMRLWLPHIKDERKGVAVTSANVHGTHFVEGFRIKDYKGRRVWTGCTGYGITR
WVVGYLAQYGFNFDDWHPIIKKKIKKLPEVPQLITWPKKDE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS2_METJA (Q58477)

Other databases:

- EMBL:   L77117
- PIR:   D64434
- RefSeq:   NP_248070.1
- ProteinModelPortal:   Q58477
- SMR:   Q58477
- GeneID:   1451973
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1077
- NMPDR:   fig|243232.1.peg.1107
- TIGR:   MJ1077
- HOGENOM:   HBG542255
- OMA:   PAQCEPF
- ProtClustDB:   PRK00960
- BioCyc:   MJAN243232:MJ_1077-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_01278
- InterPro:   IPR002314
- InterPro:   IPR004503
- TIGRFAMs:   TIGR00415

Pfam domain/function: PF00587 tRNA-synt_2b

EC number: =6.1.1.11

Molecular weight: Translated: 60633; Mature: 60633

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 316-316 BINDING 347-347 BINDING 480-480

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTFDLDGKIIFSKELSEEAKNAVEEVLKNADSIFLKGVPKGKENEASKIKSYEFEGNI
CEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCEEECCCE
LKLKIASGTYTRAHEGLIRLRKPLAEKLGRNFRIGVRGIEIDNYVITIETDEDKAKKLEG
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEECCCHHHHHHCC
IKVPECEAKVEGNKIILTFKDIGESELKRNIIDRAIKFVKTELEKEEEDLTFKVCKIPPG
CCCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
TIVSEYKAKRKITFDKDPTDVAEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVK
CHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
KIGFQECLFPKLIPLEIMYKMRYLEGLPEGMYYVCPPKREPELFKEFVNEMMIKKEIPIE
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHH
KLKNLLRDPGYVLAPAQCEPFYQFFEGEVIDVDKPIMFFDRSGWTYRWEGGGARGLDRVN
HHHHHHCCCCEEEECCCCCHHHHHHCCCEEECCCCEEEEECCCCEEEECCCCCCCHHHHH
EFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWVEVGDDPFYLEGRKKEDRGIE
HHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCC
FPDVPKYEMRLWLPHIKDERKGVAVTSANVHGTHFVEGFRIKDYKGRRVWTGCTGYGITR
CCCCCCHHHEEECCCCCCCCCCEEEEECCCCCCEEEECEEEECCCCCEEEECCCCCCHHH
WVVGYLAQYGFNFDDWHPIIKKKIKKLPEVPQLITWPKKDE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKLTFDLDGKIIFSKELSEEAKNAVEEVLKNADSIFLKGVPKGKENEASKIKSYEFEGNI
CEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCEEECCCE
LKLKIASGTYTRAHEGLIRLRKPLAEKLGRNFRIGVRGIEIDNYVITIETDEDKAKKLEG
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEECCCHHHHHHCC
IKVPECEAKVEGNKIILTFKDIGESELKRNIIDRAIKFVKTELEKEEEDLTFKVCKIPPG
CCCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
TIVSEYKAKRKITFDKDPTDVAEKLGWVKKFPGRGQWFYTPPITALFRALEELIVEEVVK
CHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
KIGFQECLFPKLIPLEIMYKMRYLEGLPEGMYYVCPPKREPELFKEFVNEMMIKKEIPIE
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHH
KLKNLLRDPGYVLAPAQCEPFYQFFEGEVIDVDKPIMFFDRSGWTYRWEGGGARGLDRVN
HHHHHHCCCCEEEECCCCCHHHHHHCCCEEECCCCEEEEECCCCEEEECCCCCCCHHHHH
EFLRVECVWIGSPEFVEETRDKTLKYAEKLAEKLDLEYWVEVGDDPFYLEGRKKEDRGIE
HHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCC
FPDVPKYEMRLWLPHIKDERKGVAVTSANVHGTHFVEGFRIKDYKGRRVWTGCTGYGITR
CCCCCCHHHEEECCCCCCCCCCEEEEECCCCCCEEEECEEEECCCCCEEEECCCCCCHHH
WVVGYLAQYGFNFDDWHPIIKKKIKKLPEVPQLITWPKKDE
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087