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The map label for this gene is serA

Identifier: 15669207

GI number: 15669207

Start: 947551

End: 949125

Strand: Reverse

Name: serA

Synonym: MJ1018

Alternate gene names: 15669207

Gene position: 949125-947551 (Counterclockwise)

Preceding gene: 15669210

Following gene: 15669204

Centisome position: 57.01

GC content: 35.37

Gene sequence:

>1575_bases
ATGGTTAAGATATTAGTTACAGACCCATTGCATGAAGATGCAATAAAGATATTAGAGGAAGTTGGAGAGGTTGAAGTAGC
TACTGGATTAACAAAAGAAGAATTGTTAGAAAAAATTAAAGATGCAGATGTTTTAGTTGTTAGAAGTGGGACAAAGGTCA
CAAGGGATGTTATTGAGAAGGCTGAAAAATTAAAGGTTATTGGTAGAGCTGGAGTTGGAGTGGATAACATAGACGTTGAA
GCAGCAACAGAAAAAGGGATTATAGTAGTTAATGCCCCTGATGCTTCATCAATCTCTGTAGCTGAGCTAACTATGGGATT
AATGCTTGCTGCTGCAAGAAACATTCCTCAAGCAACAGCATCATTAAAAAGAGGAGAATGGGATAGAAAGAGATTTAAAG
GTATTGAATTGTATGGAAAAACACTTGGAGTTATTGGTTTGGGAAGGATAGGACAGCAAGTTGTTAAGAGAGCTAAGGCA
TTTGGAATGAACATAATTGGTTACGACCCTTACATCCCAAAGGAAGTTGCTGAAAGTATGGGAGTTGAGTTGGTTGATGA
TATAAATGAGCTATGTAAGAGGGCTGATTTTATAACTCTGCATGTTCCATTAACACCAAAAACAAGACATATTATTGGTA
GAGAACAAATAGCCCTAATGAAAAAGAATGCCATAATTGTTAATTGTGCAAGAGGAGGACTTATTGATGAAAAGGCTTTA
TATGAAGCATTAAAAGAGGGTAAAATTAGAGCAGCAGCCTTGGATGTGTTTGAGGAAGAGCCACCTAAGGACAATCCATT
ATTAACGTTAGATAATGTTATAGGAACTCCACACCAAGGAGCTTCAACTGAAGAGGCACAGAAAGCAGCTGGAACTATTG
TGGCAGAGCAGATAAAGAAGGTTTTGAGAGGAGAGTTAGCTGAAAATGTTGTAAATATGCCCAATATTCCCCAAGAAAAG
TTAGGAAAACTAAAACCATACATGTTGTTGGCAGAGATGCTTGGAAACATTGTTATGCAGGTATTAGATGGTTCTGTTAA
TAGGGTTGAACTTATATATTCAGGAGAATTAGCCAAAGAAAAAACTGATTTAATAAAAAGAGCTTTCTTAAAAGGGCTTT
TGTCACCAATATTATTGGCTGGAATCAATTTGGTTAATGCCCCTATTATAGCAAAAAATAGAAATATCAATGTGGTTGAA
AGCTCAACCTCTGAAGAGAAATATGGAAATGCTATAAAAATAACTGCTGAAAGTGATAAGAAAAAATTCTCAATAGTTGG
GGCAATAATAAACAATAAACCAGTTATCTTAGAAGTTGATGGATATGAAGTTAGCTTCATTCCAGAGGGAGTTTTAGCAA
TTATTAAACATATTGATAGACCTGGCACAATTGGTAGGGTGTGCATAACATTGGGTGATTATGGAATAAATATTGCAAGT
ATGCAAGTAGGAAGAAAAGAGCCTGGAGGAGAAAGTGTAATGCTATTAAACTTAGACCATACAGTCCCTGAGGAAGTTAT
TGAAAAAATAAAAGAGATTCCAAATATTAAAGATGTTGCTGTGATAAATTTATAA

Upstream 100 bases:

>100_bases
TATATATATGATTGGGATAATCATCTATCTACTGCTTTTAGAGGACATTATGCATTTTATAATTTATGGTTGTTAATAAT
TGATGAAATGGTGAATAGAC

Downstream 100 bases:

>100_bases
TCATTATTATTTGAGTACCATGTCTCCAATTTCAAACCTTTTTAGTTCAGAGATGCTCATCCTATCCTTTAAAAACTCTT
TTGGAATCAAATATAAAAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MVKILVTDPLHEDAIKILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEKAEKLKVIGRAGVGVDNIDVE
AATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATASLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKA
FGMNIIGYDPYIPKEVAESMGVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL
YEALKEGKIRAAALDVFEEEPPKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIKKVLRGELAENVVNMPNIPQEK
LGKLKPYMLLAEMLGNIVMQVLDGSVNRVELIYSGELAKEKTDLIKRAFLKGLLSPILLAGINLVNAPIIAKNRNINVVE
SSTSEEKYGNAIKITAESDKKKFSIVGAIINNKPVILEVDGYEVSFIPEGVLAIIKHIDRPGTIGRVCITLGDYGINIAS
MQVGRKEPGGESVMLLNLDHTVPEEVIEKIKEIPNIKDVAVINL

Sequences:

>Translated_524_residues
MVKILVTDPLHEDAIKILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEKAEKLKVIGRAGVGVDNIDVE
AATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATASLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKA
FGMNIIGYDPYIPKEVAESMGVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL
YEALKEGKIRAAALDVFEEEPPKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIKKVLRGELAENVVNMPNIPQEK
LGKLKPYMLLAEMLGNIVMQVLDGSVNRVELIYSGELAKEKTDLIKRAFLKGLLSPILLAGINLVNAPIIAKNRNINVVE
SSTSEEKYGNAIKITAESDKKKFSIVGAIINNKPVILEVDGYEVSFIPEGVLAIIKHIDRPGTIGRVCITLGDYGINIAS
MQVGRKEPGGESVMLLNLDHTVPEEVIEKIKEIPNIKDVAVINL
>Mature_524_residues
MVKILVTDPLHEDAIKILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEKAEKLKVIGRAGVGVDNIDVE
AATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATASLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKA
FGMNIIGYDPYIPKEVAESMGVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL
YEALKEGKIRAAALDVFEEEPPKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIKKVLRGELAENVVNMPNIPQEK
LGKLKPYMLLAEMLGNIVMQVLDGSVNRVELIYSGELAKEKTDLIKRAFLKGLLSPILLAGINLVNAPIIAKNRNINVVE
SSTSEEKYGNAIKITAESDKKKFSIVGAIINNKPVILEVDGYEVSFIPEGVLAIIKHIDRPGTIGRVCITLGDYGINIAS
MQVGRKEPGGESVMLLNLDHTVPEEVIEKIKEIPNIKDVAVINL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Homo sapiens, GI23308577, Length=455, Percent_Identity=43.2967032967033, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI4557497, Length=315, Percent_Identity=36.5079365079365, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI61743967, Length=315, Percent_Identity=36.5079365079365, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI145580578, Length=315, Percent_Identity=36.8253968253968, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI4557499, Length=315, Percent_Identity=36.8253968253968, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI145580575, Length=315, Percent_Identity=36.8253968253968, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI6912396, Length=316, Percent_Identity=32.5949367088608, Blast_Score=155, Evalue=7e-38,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=37.1517027863777, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=36.996336996337, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1787645, Length=303, Percent_Identity=32.6732673267327, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788660, Length=330, Percent_Identity=29.6969696969697, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=46.4052287581699, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI25147481, Length=312, Percent_Identity=34.2948717948718, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=336, Percent_Identity=36.9047619047619, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322116, Length=335, Percent_Identity=36.1194029850746, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=317, Percent_Identity=35.0157728706625, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=29.2763157894737, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=180, Percent_Identity=30.5555555555556, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=296, Percent_Identity=26.6891891891892, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=46.5116279069767, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24646446, Length=320, Percent_Identity=36.5625, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24646448, Length=320, Percent_Identity=36.5625, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24646452, Length=320, Percent_Identity=36.5625, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24646450, Length=320, Percent_Identity=36.5625, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI62472511, Length=320, Percent_Identity=36.875, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI28574284, Length=315, Percent_Identity=32.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=32.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585514, Length=315, Percent_Identity=32.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574282, Length=315, Percent_Identity=32.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45552429, Length=315, Percent_Identity=32.3809523809524, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574286, Length=281, Percent_Identity=32.0284697508897, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=35.6687898089172, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=27.7955271565495, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERA_METJA (Q58424)

Other databases:

- EMBL:   L77117
- PIR:   A64427
- RefSeq:   NP_248012.1
- ProteinModelPortal:   Q58424
- SMR:   Q58424
- GeneID:   1451915
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1018
- NMPDR:   fig|243232.1.peg.1049
- TIGR:   MJ1018
- HOGENOM:   HBG731446
- OMA:   IASMQVG
- ProtClustDB:   PRK13581
- BioCyc:   MJAN243232:MJ_1018-MONOMER
- BRENDA:   1.1.1.95
- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF20
- TIGRFAMs:   TIGR01327

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT

EC number: =1.1.1.95

Molecular weight: Translated: 56924; Mature: 56924

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 231-231 ACT_SITE 260-260 ACT_SITE 278-278 BINDING 169-169 BINDING 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKILVTDPLHEDAIKILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEK
CEEEEEECCCHHHHHHHHHHHCCEEHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AEKLKVIGRAGVGVDNIDVEAATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATA
HHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
SLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKAFGMNIIGYDPYIPKEVAESM
HHHCCCCHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHC
GVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL
CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCHHHHHHEECCEEEEEECCCCCCCHHHH
YEALKEGKIRAAALDVFEEEPPKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIKK
HHHHHCCCEEEEHHHHHHCCCCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
VLRGELAENVVNMPNIPQEKLGKLKPYMLLAEMLGNIVMQVLDGSVNRVELIYSGELAKE
HHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
KTDLIKRAFLKGLLSPILLAGINLVNAPIIAKNRNINVVESSTSEEKYGNAIKITAESDK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCHHHCCCEEEEEECCCC
KKFSIVGAIINNKPVILEVDGYEVSFIPEGVLAIIKHIDRPGTIGRVCITLGDYGINIAS
CEEEEEEEEECCCCEEEEECCEEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
MQVGRKEPGGESVMLLNLDHTVPEEVIEKIKEIPNIKDVAVINL
EECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MVKILVTDPLHEDAIKILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEK
CEEEEEECCCHHHHHHHHHHHCCEEHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AEKLKVIGRAGVGVDNIDVEAATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATA
HHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
SLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKAFGMNIIGYDPYIPKEVAESM
HHHCCCCHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHC
GVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL
CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHCHHHHHHEECCEEEEEECCCCCCCHHHH
YEALKEGKIRAAALDVFEEEPPKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIKK
HHHHHCCCEEEEHHHHHHCCCCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
VLRGELAENVVNMPNIPQEKLGKLKPYMLLAEMLGNIVMQVLDGSVNRVELIYSGELAKE
HHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
KTDLIKRAFLKGLLSPILLAGINLVNAPIIAKNRNINVVESSTSEEKYGNAIKITAESDK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCHHHCCCEEEEEECCCC
KKFSIVGAIINNKPVILEVDGYEVSFIPEGVLAIIKHIDRPGTIGRVCITLGDYGINIAS
CEEEEEEEEECCCCEEEEECCEEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
MQVGRKEPGGESVMLLNLDHTVPEEVIEKIKEIPNIKDVAVINL
EECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087