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The map label for this gene is trpC

Identifier: 15669108

GI number: 15669108

Start: 849675

End: 850475

Strand: Reverse

Name: trpC

Synonym: MJ0918

Alternate gene names: 15669108

Gene position: 850475-849675 (Counterclockwise)

Preceding gene: 15669109

Following gene: 15669106

Centisome position: 51.08

GC content: 29.09

Gene sequence:

>801_bases
ATGAAAGTCTTAGATGAAATTGTAGCAAATAGAAAAAAAATGGTTGAGATAGAAAAGAGAAAAGACATAATCAAAAACTT
AAGGAGTTTTATCGATGAATTAGATATAGATGTAGAAAAAAAGAGAAAGTTAAGATTATCAAAAGCCATAAAAAAAGCTA
AAGAAATAAAAAACCCAATAATTACAGAGATTAAGCCATCTTCTCCATCAAAAGGTAGCATAAGAGAAATAAATCTCGAA
GATGTAAAAAATATTGCCAATGAAATGGTGGAAGGAGGAGCAACAGCTTTATCTATTTTAACTGAACCAAAATACTTCAA
TGGAAGTTATAAAAATTTAATTGTTGCAAGAGAATTTGATATTCCCATATTGATGAAAGATTTTATTGTTGATTTTTATC
AGATTGATGTAGCAAGTGAGATTGGAGCTAATGCAGTGTTATTAATTGTTTCATCATTAAAAGAAGACATTGGAGAGTTT
TTAGATTATGCAAAAGAAAATGATTTGGAATGTTTAGTTGAGACGCACAGTGAAGATGAAATAGATATAGCTTTAGATGC
TGGAGCTAAAATTATAGGCATAAATAACAGAGATTTAAAAACCCTAAAGATTGATTTATCTACAACTGAAAAATTGGCCC
CATTAATCCCAAAAAATAAAATAAAGGTTGGAGAGAGTGGTATATATACAAAGGAGCAGTTAAATTATGTTTTAAAATTC
ACTGACGCTGCTTTAATTGGCTCATCAATAATGGAGAGTGAAAATATAAGAGAGAAAGTTAGGGAGTTCGTGATAAAGTA
A

Upstream 100 bases:

>100_bases
AAAGAAGAAAAAGAAGAAAATAGTGAATAAGAGCTTATACTATTATTTTATTTTATCCTACCTTTTTTAAATAGCAATTC
TTTTTATTAAATGTGATAAT

Downstream 100 bases:

>100_bases
TTTATTTAATTCCAAGGCATCTGCTCAACTTATTATAAAAACTCTGCCCCTTTACAAAATAAGCATAGCTGTCGGATTTT
TCAAAGATTAACTCATCATC

Product: indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase TrpC

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKVLDEIVANRKKMVEIEKRKDIIKNLRSFIDELDIDVEKKRKLRLSKAIKKAKEIKNPIITEIKPSSPSKGSIREINLE
DVKNIANEMVEGGATALSILTEPKYFNGSYKNLIVAREFDIPILMKDFIVDFYQIDVASEIGANAVLLIVSSLKEDIGEF
LDYAKENDLECLVETHSEDEIDIALDAGAKIIGINNRDLKTLKIDLSTTEKLAPLIPKNKIKVGESGIYTKEQLNYVLKF
TDAALIGSSIMESENIREKVREFVIK

Sequences:

>Translated_266_residues
MKVLDEIVANRKKMVEIEKRKDIIKNLRSFIDELDIDVEKKRKLRLSKAIKKAKEIKNPIITEIKPSSPSKGSIREINLE
DVKNIANEMVEGGATALSILTEPKYFNGSYKNLIVAREFDIPILMKDFIVDFYQIDVASEIGANAVLLIVSSLKEDIGEF
LDYAKENDLECLVETHSEDEIDIALDAGAKIIGINNRDLKTLKIDLSTTEKLAPLIPKNKIKVGESGIYTKEQLNYVLKF
TDAALIGSSIMESENIREKVREFVIK
>Mature_266_residues
MKVLDEIVANRKKMVEIEKRKDIIKNLRSFIDELDIDVEKKRKLRLSKAIKKAKEIKNPIITEIKPSSPSKGSIREINLE
DVKNIANEMVEGGATALSILTEPKYFNGSYKNLIVAREFDIPILMKDFIVDFYQIDVASEIGANAVLLIVSSLKEDIGEF
LDYAKENDLECLVETHSEDEIDIALDAGAKIIGINNRDLKTLKIDLSTTEKLAPLIPKNKIKVGESGIYTKEQLNYVLKF
TDAALIGSSIMESENIREKVREFVIK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=265, Percent_Identity=36.9811320754717, Blast_Score=137, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322638, Length=281, Percent_Identity=32.3843416370107, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_METJA (Q58328)

Other databases:

- EMBL:   L77117
- PIR:   F64414
- RefSeq:   NP_247913.1
- ProteinModelPortal:   Q58328
- SMR:   Q58328
- GeneID:   1451807
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0918
- NMPDR:   fig|243232.1.peg.950
- TIGR:   MJ0918
- HOGENOM:   HBG540956
- OMA:   VICEVKR
- ProtClustDB:   CLSK2517668
- BioCyc:   MJAN243232:MJ_0918-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_A
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 30027; Mature: 30027

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLDEIVANRKKMVEIEKRKDIIKNLRSFIDELDIDVEKKRKLRLSKAIKKAKEIKNPI
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
ITEIKPSSPSKGSIREINLEDVKNIANEMVEGGATALSILTEPKYFNGSYKNLIVAREFD
EECCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEHEEECCCCCCCCCCEEEEEEECC
IPILMKDFIVDFYQIDVASEIGANAVLLIVSSLKEDIGEFLDYAKENDLECLVETHSEDE
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
IDIALDAGAKIIGINNRDLKTLKIDLSTTEKLAPLIPKNKIKVGESGIYTKEQLNYVLKF
EEEEEECCCEEEECCCCCCEEEEEECCCHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHH
TDAALIGSSIMESENIREKVREFVIK
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVLDEIVANRKKMVEIEKRKDIIKNLRSFIDELDIDVEKKRKLRLSKAIKKAKEIKNPI
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
ITEIKPSSPSKGSIREINLEDVKNIANEMVEGGATALSILTEPKYFNGSYKNLIVAREFD
EECCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEHEEECCCCCCCCCCEEEEEEECC
IPILMKDFIVDFYQIDVASEIGANAVLLIVSSLKEDIGEFLDYAKENDLECLVETHSEDE
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
IDIALDAGAKIIGINNRDLKTLKIDLSTTEKLAPLIPKNKIKVGESGIYTKEQLNYVLKF
EEEEEECCCEEEECCCCCCEEEEEECCCHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHH
TDAALIGSSIMESENIREKVREFVIK
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087