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The map label for this gene is mvp

Identifier: 15668309

GI number: 15668309

Start: 136614

End: 137243

Strand: Direct

Name: mvp

Synonym: MJ0139

Alternate gene names: 15668309

Gene position: 136614-137243 (Clockwise)

Preceding gene: 15668306

Following gene: 15668310

Centisome position: 8.21

GC content: 27.78

Gene sequence:

>630_bases
ATGAACTTAAAAGATAGGCGGTTAAAGAAAATAATGGAAGTATTGAGTTTAATTTTTACATTTGAGATAGTCGCTTCTTT
CATTCTCTCAACATATAATCCACCGTATCAAGACTTACTAATAAAGTTAGATTATATCTCTATTATGTTCTTTACATTTG
AGTTTATATACAATTTTTATTATGTTGAAGACAAGGCAAAGTTTTTTAAAGACATTTACAATATTGTTGATGCCATAGTT
GTTATTGCTTTCTTACTGTATTCTTTACAGGTATTTTATTCAAAGGCATTCTTAGGACTTAGGGTTATAAACCTACTAAG
AATTTTAGTTTTACTTAGAATAATTAAGTTAAGAAAGTTAGAAGAAAATCAGGCATTAATAAACTTTCTAACATTATTAA
CAATTTGCTTTATTGCTTCCTGCTTAATATGGATTGTCGAATCAGGTGTAAATCCAGCAATAAACAATTTCTTTGATGCT
TTTTATTTCACAACAATATCAATAACAACGGTTGGTTATGGAGATATAACACCAAAAACAGATGCTGGGAAGCTAATAAT
AATATTCTCAGTCCTATTCTTTATATCTGGTTTAATAACCTCTTTACAAAAGGCATTAAAGGGAGATTAA

Upstream 100 bases:

>100_bases
ATCTTCAAATAATGGAAGAGACCCCTTAATATCCAAAATACCAATTTCCATTGGATATCACCAAAAATATTTGTTATAAA
AATTTCAAATTGGGATATAA

Downstream 100 bases:

>100_bases
ATGGAAACTTATGAGAAGATAGAGCTTGGTATAATAGTTATCATCTTACTCATCTTAATTGAATCAGTAATATTAATGAC
AGTTGAAGGCTGGGACTTTT

Product: potassium channel protein

Products: K (I) [Cytoplasm] [C]

Alternate protein names: MVP

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNLKDRRLKKIMEVLSLIFTFEIVASFILSTYNPPYQDLLIKLDYISIMFFTFEFIYNFYYVEDKAKFFKDIYNIVDAIV
VIAFLLYSLQVFYSKAFLGLRVINLLRILVLLRIIKLRKLEENQALINFLTLLTICFIASCLIWIVESGVNPAINNFFDA
FYFTTISITTVGYGDITPKTDAGKLIIIFSVLFFISGLITSLQKALKGD

Sequences:

>Translated_209_residues
MNLKDRRLKKIMEVLSLIFTFEIVASFILSTYNPPYQDLLIKLDYISIMFFTFEFIYNFYYVEDKAKFFKDIYNIVDAIV
VIAFLLYSLQVFYSKAFLGLRVINLLRILVLLRIIKLRKLEENQALINFLTLLTICFIASCLIWIVESGVNPAINNFFDA
FYFTTISITTVGYGDITPKTDAGKLIIIFSVLFFISGLITSLQKALKGD
>Mature_209_residues
MNLKDRRLKKIMEVLSLIFTFEIVASFILSTYNPPYQDLLIKLDYISIMFFTFEFIYNFYYVEDKAKFFKDIYNIVDAIV
VIAFLLYSLQVFYSKAFLGLRVINLLRILVLLRIIKLRKLEENQALINFLTLLTICFIASCLIWIVESGVNPAINNFFDA
FYFTTISITTVGYGDITPKTDAGKLIIIFSVLFFISGLITSLQKALKGD

Specific function: Voltage-gated potassium-selective channel opened by hyperpolarization

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family

Homologues:

Organism=Homo sapiens, GI27436974, Length=210, Percent_Identity=29.0476190476191, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4826784, Length=210, Percent_Identity=29.5238095238095, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI238624130, Length=200, Percent_Identity=24, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI45383011, Length=180, Percent_Identity=28.8888888888889, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27436986, Length=168, Percent_Identity=25.5952380952381, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI27436984, Length=168, Percent_Identity=25.5952380952381, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI9789987, Length=168, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4504817, Length=188, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI4826782, Length=183, Percent_Identity=28.9617486338798, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27436981, Length=171, Percent_Identity=26.9005847953216, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI236462242, Length=197, Percent_Identity=27.4111675126904, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI236462079, Length=197, Percent_Identity=27.4111675126904, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI236461942, Length=197, Percent_Identity=27.4111675126904, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI236461719, Length=197, Percent_Identity=27.4111675126904, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI28373065, Length=197, Percent_Identity=27.4111675126904, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI24497460, Length=189, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147238, Length=206, Percent_Identity=27.1844660194175, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25147242, Length=206, Percent_Identity=27.1844660194175, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI72001309, Length=201, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72001311, Length=201, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72001307, Length=201, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330117, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221330119, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281363097, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281363095, Length=208, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281365536, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007764, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656289, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656294, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24642914, Length=205, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642916, Length=205, Percent_Identity=26.3414634146341, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MVP_METJA (Q57603)

Other databases:

- EMBL:   AY268105
- EMBL:   L77117
- PIR:   C64317
- RefSeq:   NP_247105.1
- ProteinModelPortal:   Q57603
- GeneID:   1450980
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0139
- NMPDR:   fig|243232.1.peg.142
- TIGR:   MJ0139
- HOGENOM:   HBG541057
- OMA:   STYNPPY
- ProtClustDB:   CLSK796293
- BioCyc:   MJAN243232:MJ_0139-MONOMER
- InterPro:   IPR013099
- InterPro:   IPR003091
- PRINTS:   PR00169

Pfam domain/function: PF07885 Ion_trans_2

EC number: NA

Molecular weight: Translated: 24183; Mature: 24183

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xaed8608)-; HASH(0xc311834)-; HASH(0xbe9385c)-; HASH(0xae2e2d8)-; HASH(0xc311894)-; HASH(0xae15c94)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDRRLKKIMEVLSLIFTFEIVASFILSTYNPPYQDLLIKLDYISIMFFTFEFIYNFY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YVEDKAKFFKDIYNIVDAIVVIAFLLYSLQVFYSKAFLGLRVINLLRILVLLRIIKLRKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EENQALINFLTLLTICFIASCLIWIVESGVNPAINNFFDAFYFTTISITTVGYGDITPKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCC
DAGKLIIIFSVLFFISGLITSLQKALKGD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MNLKDRRLKKIMEVLSLIFTFEIVASFILSTYNPPYQDLLIKLDYISIMFFTFEFIYNFY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YVEDKAKFFKDIYNIVDAIVVIAFLLYSLQVFYSKAFLGLRVINLLRILVLLRIIKLRKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EENQALINFLTLLTICFIASCLIWIVESGVNPAINNFFDAFYFTTISITTVGYGDITPKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCC
DAGKLIIIFSVLFFISGLITSLQKALKGD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: K (I) [Periplasm] [C]

Specific reaction: K (I) [Periplasm] = K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12640457; 8688087