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The map label for this gene is nrdA

Identifier: 30995466

GI number: 30995466

Start: 1724513

End: 1726783

Strand: Direct

Name: nrdA

Synonym: HI1659

Alternate gene names: 30995466

Gene position: 1724513-1726783 (Clockwise)

Preceding gene: 16273545

Following gene: 16273547

Centisome position: 94.23

GC content: 38.13

Gene sequence:

>2271_bases
ATGAATAAAAGTTTAATGGTTACAAAGCGTGACGGTACGCAAGAACAAATCAATCTTGATAAAATCCATCGTGTGATTAC
GTGGGCTGCTGAAGGACTAGACAATGTTTCTGTTTCTCAAGTAGAACTTCGTTCACATATTCAATTTTATGAAGGCATTC
GCACTTCAGACATCCACGAAACCATTATTAAAGCAGCCGCAGATTTAATCAGCAAAGATTCGCCAGATTATCAATATTTA
GCTGCTCGTTTAGCGATTTTCCATTTACGTAAAAAAGCCTATGGTCATTTCGATCCCCCTCGTTTATACGATCACGTCAA
AAAACTAGTACGTATGGAAAAATATGATCAAGCGTTATTAGATGATTATACTCGTGAAGAATGGGACACAATGGACGGCT
TCATCGATCATTGGCGTGATATGACGTTTTCTTATGCAGCAGTGAAGCAATTGGAGGGTAAATATTTAGTACAAAACCGT
GTGACGGGAGAAATCTACGAGTCTGCACAATTCTTATATTTGCTGGTTTCCGCAAGTCTATTCTCTAAATATCCAAAAGA
AACACGTTTGGATTATGTAAAACGTTTCTACGATGCCACATCGACTTTCAAAATTTCCTTACCTACACCAATTATGGCGG
GCGTGCGTACACCAACTCGTCAGTTCAGCTCTTGCGTATTAATTGAATGTGATGACAGTTTAGATTCTATCAATGCAACA
GCATCAGCTATTGTAAAATATGTTTCACAACGTGCAGGGATTGGTATTAATGCAGGGGCTATTCGTGCATTAGGTAGCGA
AATTCGTGGTGGAGAAGCATTCCATACAGGTTGTATTCCATTCTATAAATATTTCCAAACTGCAGTTAAATCTTGCTCAC
AAGGTGGCGTTCGTGGCGGTGCAGCAACACTTTATTACCCAATTTGGCACTTAGAAGCAGAAAACTTGCTCGTATTAAAA
AATAACCGTGGTGTAGAAGACAACCGTGTTCGTCATATGGATTATGGCGTGCAATTAAACAAATTAATGTATCAACGCTT
AATTAAAGGCAGCGAGATTACTTTATTTAGTCCATCAGATGTACCTGGACTTTATGAAGCATTCTTTGCGGATCAAGACA
AATTTGAAGAACTTTACGTAAAATACGAACAAGATCCAACTATCCGTAAGCGTACTGTTAAAGCAGTTGAAATCTTTTCT
TTATTAATGCAAGAACGGGCATCAACGGGTCGAATTTACATTCAAAACGTGGATCACTGTAATACCCACTCTCCGTTTGA
TCCACAAGTTGCACCAGTTCGTCAATCTAACTTATGCTTAGAAATTGCATTACCAACTAAACCGCTTCAGCACATTAACG
ATGAAAATGGGGAAATTGCACTTTGTACACTTTCCGCCTTTAACTTAGGTAAAATTGAAAACTTAGATGAATTAGAAGAA
CTTGCGGATCTTGCTGTTCGTTCTCTTGATGCCTTATTAGACTATCAAGATTATCCTGTTGTGGCAGCAAAACGTAGCTC
ACTTGCACGCCGTTCACTCGGTATTGGGGTCATTAACTATGCGTATTACCTTGCGAAAAATGGTGTTCGCTATTCTGATG
GTTCAGCCAACGATTTAACACACCGTACTTTTGAAGCCATTCAATATTATTTATTGAAAGCCTCTATGAACTTAGCAAAA
GAGCAAGGTGCGTGTGAATACTTCAATGAAACCACTTATGCAAAAGGCATTTTACCGATTGATACCTATAAGAAAGATTT
AGATTCCTTAACACAAGAGCCTCTACATTATGATTGGGAAAGTTTACGTAAAGATATTCAAGAATTTGGTTTACGTAACT
CAACATTAACTGCCTTAATGCCATCAGAAACATCATCGCAGATTTCCAATGCGACTAATGGTATTGAGCCACCACGCGGT
CACGTAAGTATTAAAGCATCAAAAGATGGTATCTTAAAACAAGTTGTACCTGAATATGAAAATTTAATGGATAACTATGA
ATTACTTTGGGATATTCCAAGTAATGACGGCTACTTACACTTAGTCGGTATTATGCAAAAATTCGTGGATCAAGCGATCT
CTGCAAACACAAACTATGATCCAAAACGTTTTGAAGACGGCAAAGTACCAATGAAAGTGTTGTTAAAAGATTTATTAACC
GCTTACAAATACGGTTTAAAAACCCTTTACTATCAAAATACCCGCGACGGTGCCGAAGATGTTCAAGAAGATCTTGATGA
CGGCTGTGCTGGTGGTGCTTGCAAAATTTAA

Upstream 100 bases:

>100_bases
GATCTTTTCTCAAACACATTATCTTGTGGATCGTTTTCATAAAAACACTATATCTTGTGTTTTAAATCCTGTTTTAAATA
ACAACAAGAAGGCTCATACA

Downstream 100 bases:

>100_bases
ACGCCCCTATTGTCTTCCCCAACTTATGGGGAAGATAGCACGACATAACGAATTAGGATACTTTCCTCAGTCTTTGATAG
TTTCCCCTGATAAACAGGGA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MNKSLMVTKRDGTQEQINLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAIFHLRKKAYGHFDPPRLYDHVKKLVRMEKYDQALLDDYTREEWDTMDGFIDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSASLFSKYPKETRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECDDSLDSINAT
ASAIVKYVSQRAGIGINAGAIRALGSEIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATLYYPIWHLEAENLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGSEITLFSPSDVPGLYEAFFADQDKFEELYVKYEQDPTIRKRTVKAVEIFS
LLMQERASTGRIYIQNVDHCNTHSPFDPQVAPVRQSNLCLEIALPTKPLQHINDENGEIALCTLSAFNLGKIENLDELEE
LADLAVRSLDALLDYQDYPVVAAKRSSLARRSLGIGVINYAYYLAKNGVRYSDGSANDLTHRTFEAIQYYLLKASMNLAK
EQGACEYFNETTYAKGILPIDTYKKDLDSLTQEPLHYDWESLRKDIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSIKASKDGILKQVVPEYENLMDNYELLWDIPSNDGYLHLVGIMQKFVDQAISANTNYDPKRFEDGKVPMKVLLKDLLT
AYKYGLKTLYYQNTRDGAEDVQEDLDDGCAGGACKI

Sequences:

>Translated_756_residues
MNKSLMVTKRDGTQEQINLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAIFHLRKKAYGHFDPPRLYDHVKKLVRMEKYDQALLDDYTREEWDTMDGFIDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSASLFSKYPKETRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECDDSLDSINAT
ASAIVKYVSQRAGIGINAGAIRALGSEIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATLYYPIWHLEAENLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGSEITLFSPSDVPGLYEAFFADQDKFEELYVKYEQDPTIRKRTVKAVEIFS
LLMQERASTGRIYIQNVDHCNTHSPFDPQVAPVRQSNLCLEIALPTKPLQHINDENGEIALCTLSAFNLGKIENLDELEE
LADLAVRSLDALLDYQDYPVVAAKRSSLARRSLGIGVINYAYYLAKNGVRYSDGSANDLTHRTFEAIQYYLLKASMNLAK
EQGACEYFNETTYAKGILPIDTYKKDLDSLTQEPLHYDWESLRKDIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSIKASKDGILKQVVPEYENLMDNYELLWDIPSNDGYLHLVGIMQKFVDQAISANTNYDPKRFEDGKVPMKVLLKDLLT
AYKYGLKTLYYQNTRDGAEDVQEDLDDGCAGGACKI
>Mature_756_residues
MNKSLMVTKRDGTQEQINLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAIFHLRKKAYGHFDPPRLYDHVKKLVRMEKYDQALLDDYTREEWDTMDGFIDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSASLFSKYPKETRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECDDSLDSINAT
ASAIVKYVSQRAGIGINAGAIRALGSEIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATLYYPIWHLEAENLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGSEITLFSPSDVPGLYEAFFADQDKFEELYVKYEQDPTIRKRTVKAVEIFS
LLMQERASTGRIYIQNVDHCNTHSPFDPQVAPVRQSNLCLEIALPTKPLQHINDENGEIALCTLSAFNLGKIENLDELEE
LADLAVRSLDALLDYQDYPVVAAKRSSLARRSLGIGVINYAYYLAKNGVRYSDGSANDLTHRTFEAIQYYLLKASMNLAK
EQGACEYFNETTYAKGILPIDTYKKDLDSLTQEPLHYDWESLRKDIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSIKASKDGILKQVVPEYENLMDNYELLWDIPSNDGYLHLVGIMQKFVDQAISANTNYDPKRFEDGKVPMKVLLKDLLT
AYKYGLKTLYYQNTRDGAEDVQEDLDDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Homo sapiens, GI4506749, Length=796, Percent_Identity=28.7688442211055, Blast_Score=256, Evalue=5e-68,
Organism=Escherichia coli, GI2367133, Length=761, Percent_Identity=83.0486202365309, Blast_Score=1334, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=579, Percent_Identity=26.5975820379965, Blast_Score=158, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17555242, Length=793, Percent_Identity=27.2383354350567, Blast_Score=235, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6322123, Length=796, Percent_Identity=27.8894472361809, Blast_Score=254, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6320914, Length=806, Percent_Identity=27.4193548387097, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI17352481, Length=787, Percent_Identity=27.700127064803, Blast_Score=258, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIR1_HAEIN (P43754)

Other databases:

- EMBL:   L42023
- PIR:   B64135
- RefSeq:   NP_439801.2
- ProteinModelPortal:   P43754
- SMR:   P43754
- GeneID:   950495
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1659
- NMPDR:   fig|71421.1.peg.1573
- TIGR:   HI_1659
- HOGENOM:   HBG297012
- OMA:   TTYAQGI
- ProtClustDB:   PRK09103
- BioCyc:   HINF71421:HI_1659-MONOMER
- BRENDA:   1.17.4.1
- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- PANTHER:   PTHR11573
- PRINTS:   PR01183
- TIGRFAMs:   TIGR02506

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; SSF48168 Ribonucleo_red_N

EC number: =1.17.4.1

Molecular weight: Translated: 85697; Mature: 85697

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS51161 ATP_CONE; PS00089 RIBORED_LARGE

Important sites: ACT_SITE 437-437 ACT_SITE 439-439 ACT_SITE 441-441 BINDING 9-9 BINDING 55-55 BINDING 91-91 BINDING 209-209 BINDING 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSLMVTKRDGTQEQINLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHE
CCCCEEEEECCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TIIKAAADLISKDSPDYQYLAARLAIFHLRKKAYGHFDPPRLYDHVKKLVRMEKYDQALL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DDYTREEWDTMDGFIDHWRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVSASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPKETRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECDDSLDSINAT
HHHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHHHHH
ASAIVKYVSQRAGIGINAGAIRALGSEIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCC
AATLYYPIWHLEAENLLVLKNNRGVEDNRVRHMDYGVQLNKLMYQRLIKGSEITLFSPSD
CEEEEEEEEEECCCCEEEEECCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCEEEEECCCC
VPGLYEAFFADQDKFEELYVKYEQDPTIRKRTVKAVEIFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDPQVAPVRQSNLCLEIALPTKPLQHINDENGEIALCTLSAFNLGKIENLDELEE
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHH
LADLAVRSLDALLDYQDYPVVAAKRSSLARRSLGIGVINYAYYLAKNGVRYSDGSANDLT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCHHH
HRTFEAIQYYLLKASMNLAKEQGACEYFNETTYAKGILPIDTYKKDLDSLTQEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCHH
SLRKDIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRGHVSIKASKDGILKQVVPEYE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
NLMDNYELLWDIPSNDGYLHLVGIMQKFVDQAISANTNYDPKRFEDGKVPMKVLLKDLLT
HHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDVQEDLDDGCAGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNKSLMVTKRDGTQEQINLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHE
CCCCEEEEECCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TIIKAAADLISKDSPDYQYLAARLAIFHLRKKAYGHFDPPRLYDHVKKLVRMEKYDQALL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DDYTREEWDTMDGFIDHWRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVSASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPKETRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECDDSLDSINAT
HHHCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHHHHH
ASAIVKYVSQRAGIGINAGAIRALGSEIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCC
AATLYYPIWHLEAENLLVLKNNRGVEDNRVRHMDYGVQLNKLMYQRLIKGSEITLFSPSD
CEEEEEEEEEECCCCEEEEECCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCEEEEECCCC
VPGLYEAFFADQDKFEELYVKYEQDPTIRKRTVKAVEIFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDPQVAPVRQSNLCLEIALPTKPLQHINDENGEIALCTLSAFNLGKIENLDELEE
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHH
LADLAVRSLDALLDYQDYPVVAAKRSSLARRSLGIGVINYAYYLAKNGVRYSDGSANDLT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCHHH
HRTFEAIQYYLLKASMNLAKEQGACEYFNETTYAKGILPIDTYKKDLDSLTQEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCHH
SLRKDIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRGHVSIKASKDGILKQVVPEYE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
NLMDNYELLWDIPSNDGYLHLVGIMQKFVDQAISANTNYDPKRFEDGKVPMKVLLKDLLT
HHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDVQEDLDDGCAGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800