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The map label for this gene is grxD

Identifier: 30995428

GI number: 30995428

Start: 1236513

End: 1236836

Strand: Direct

Name: grxD

Synonym: HI1165

Alternate gene names: 30995428

Gene position: 1236513-1236836 (Clockwise)

Preceding gene: 16273088

Following gene: 16273092

Centisome position: 67.56

GC content: 37.35

Gene sequence:

>324_bases
ATGGAAACCTTAGACAAAATCAAAAAGCAAATTAGTGAAAATCCCATTCTTATTTATATGAAAGGTTCGCCAAAATTACC
ATCTTGTGGTTTTCCTGCTCGTGCATCTGAGGCATTAATGCACTGCAAAGTGCCCTTTGGTTATGTGGATATTTTACAAC
ATCCAGATATTCGCGCTGAATTACCAACATATGCAAATTGGCCAACTTTCCCACAATTATGGGTTGAGGGAGAATTAATT
GGTGGTTGTGATATTATTTTAGAAATGTATCAAGCAGGCGAATTGCAAACTTTATTAGCTGAAGTGGCAGCAAAGCACGC
TTAA

Upstream 100 bases:

>100_bases
CGGTTTAGGCCTTTTGTTTTAAATGAATATAAAACCAAGCATTTCAATCAAGTTTTAACTTGTGATAAAATGCTTATCTC
GTTTATTTATAGGGAACATT

Downstream 100 bases:

>100_bases
TAACAGTGGAAAAATAAAACCCGCAATAAGCGGGTTTTTTATATAATAAATTTCCCTTTCATTATTAAATAATAGATTAA
GCAAACTTTAATACCTTAGA

Product: hypothetical protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAELPTYANWPTFPQLWVEGELI
GGCDIILEMYQAGELQTLLAEVAAKHA

Sequences:

>Translated_107_residues
METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAELPTYANWPTFPQLWVEGELI
GGCDIILEMYQAGELQTLLAEVAAKHA
>Mature_107_residues
METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAELPTYANWPTFPQLWVEGELI
GGCDIILEMYQAGELQTLLAEVAAKHA

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain

Homologues:

Organism=Homo sapiens, GI95113651, Length=93, Percent_Identity=41.9354838709677, Blast_Score=87, Evalue=2e-18,
Organism=Homo sapiens, GI42516576, Length=95, Percent_Identity=35.7894736842105, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1787943, Length=104, Percent_Identity=73.0769230769231, Blast_Score=171, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17556042, Length=101, Percent_Identity=32.6732673267327, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71988159, Length=93, Percent_Identity=37.6344086021505, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988153, Length=93, Percent_Identity=37.6344086021505, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=107, Percent_Identity=38.3177570093458, Blast_Score=87, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321022, Length=83, Percent_Identity=40.9638554216867, Blast_Score=85, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320303, Length=83, Percent_Identity=42.1686746987952, Blast_Score=85, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24642023, Length=93, Percent_Identity=37.6344086021505, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921242, Length=95, Percent_Identity=40, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLRX4_HAEIN (P45085)

Other databases:

- EMBL:   L42023
- PIR:   F64168
- RefSeq:   NP_439323.2
- ProteinModelPortal:   P45085
- SMR:   P45085
- GeneID:   949810
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1165
- NMPDR:   fig|71421.1.peg.1118
- TIGR:   HI_1165
- HOGENOM:   HBG728471
- OMA:   ILIELYQ
- ProtClustDB:   CLSK918307
- BioCyc:   HINF71421:HI_1165-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10293
- PIRSF:   PIRSF005894
- TIGRFAMs:   TIGR00365

Pfam domain/function: PF00462 Glutaredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11941; Mature: 11941

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS51354 GLUTAREDOXIN_2

Important sites: BINDING 21-21 BINDING 58-58 BINDING 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCC
LPTYANWPTFPQLWVEGELIGGCDIILEMYQAGELQTLLAEVAAKHA
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
METLDKIKKQISENPILIYMKGSPKLPSCGFPARASEALMHCKVPFGYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCC
LPTYANWPTFPQLWVEGELIGGCDIILEMYQAGELQTLLAEVAAKHA
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800