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The map label for this gene is menC [H]

Identifier: 30995414

GI number: 30995414

Start: 1026452

End: 1027477

Strand: Direct

Name: menC [H]

Synonym: HI0969

Alternate gene names: 30995414

Gene position: 1026452-1027477 (Clockwise)

Preceding gene: 16272905

Following gene: 16272907

Centisome position: 56.09

GC content: 42.01

Gene sequence:

>1026_bases
GTGAATTTTGACCGCACTTTTGTATTGGGAGCAAGCATGGCTGAAAAATCATTTAATCTTTACCGTTATTCTATCCCCGT
TGATAGCCAACTTATTCTGCGTGATCGTTTTTTAAAACGCCGTGAAGGCTTAATCGTAAGAGTGAGTTGCAGCCGAGACG
GTTGGGGAGAAATCGCTCCGCTACCTGGTTTTAGCGAAGAAACCTTAGACCAAGCTCAAGAACAAGCAATAGAATGGCTA
ACGACATGGTGCAATGCAAGCTGTGACGCACCTCGCGTACCATTAGATGGCACCTATCCCTCCGTTGCTTTTGGTATCAG
TTGCGCAATGGATGAAATGAAAGGTTATTTACAAGCTGAAGGCAATTATCATACAGCACCACTTTGTTATGGCGATCCAG
ATGAATTGTACGCCAAACTTGCGAGCATGGAAGGCGAAAAAGTAGCAAAGATGAAAGTGGGCATATACGAAGCCAATCGC
GATGGATTAATTGCCGATATGTTTTTAGAAGCCATTCCCGATTTACAATTACGGCTTGATGCAAACCGCCATTGGTCGTT
AGAAAAAGCCTTACAATTTGCCGCTAAAGTCAAACTGCAACATAGAAAACGTATTCAATTTTTAGAAGAACCTTGTAAAA
CACAAGCACTCAGCCGTGAATTTGCAGTTCAAACCGACATCGCGATTGCATGGGATGAATCCGTGCGAGAGCCTAATTTT
TGCTTGGAAAAAGAACCGCACTTATCGGCTGTCGTAATCAAACCCACTTTAATTGGTTCAATTCAACGTTGTACTGAGCT
CATTAACCAAGCACATTCGTTAGGTCTAAAAGCGGTTATTAGTTCAAGTATCGAAAGCAGTTTAGGGCTCTCTCAGCTTG
CACGAATCGCACAACAATACACCCCGAATGTGACTCCAGGCTTAGATACTTTAGATTTGATGGAATATCAAGTACTACGC
GCTTGGCCTAGTTCTGATTTACCTATTGTTGATTTAGAATCTGAATTTATCACTAAAATTATCTGA

Upstream 100 bases:

>100_bases
AAGAAGGCCGCAATGCGTTTAACGAAAAACGCGCCCCAGACTTCAGCAAATTCAGACGTAACCCTTAATTTATCGTTCTA
AAGTGCGGTTAAAAATCTTC

Downstream 100 bases:

>100_bases
TTCGACCACCAAAAATCGAAAAAACCAGTATAATGTGCCACACAAAAAGGATTAAAAATGTCGCAAACACACAGAATTTT
GCTGTTAAATGGCCCGAACT

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNFDRTFVLGASMAEKSFNLYRYSIPVDSQLILRDRFLKRREGLIVRVSCSRDGWGEIAPLPGFSEETLDQAQEQAIEWL
TTWCNASCDAPRVPLDGTYPSVAFGISCAMDEMKGYLQAEGNYHTAPLCYGDPDELYAKLASMEGEKVAKMKVGIYEANR
DGLIADMFLEAIPDLQLRLDANRHWSLEKALQFAAKVKLQHRKRIQFLEEPCKTQALSREFAVQTDIAIAWDESVREPNF
CLEKEPHLSAVVIKPTLIGSIQRCTELINQAHSLGLKAVISSSIESSLGLSQLARIAQQYTPNVTPGLDTLDLMEYQVLR
AWPSSDLPIVDLESEFITKII

Sequences:

>Translated_341_residues
MNFDRTFVLGASMAEKSFNLYRYSIPVDSQLILRDRFLKRREGLIVRVSCSRDGWGEIAPLPGFSEETLDQAQEQAIEWL
TTWCNASCDAPRVPLDGTYPSVAFGISCAMDEMKGYLQAEGNYHTAPLCYGDPDELYAKLASMEGEKVAKMKVGIYEANR
DGLIADMFLEAIPDLQLRLDANRHWSLEKALQFAAKVKLQHRKRIQFLEEPCKTQALSREFAVQTDIAIAWDESVREPNF
CLEKEPHLSAVVIKPTLIGSIQRCTELINQAHSLGLKAVISSSIESSLGLSQLARIAQQYTPNVTPGLDTLDLMEYQVLR
AWPSSDLPIVDLESEFITKII
>Mature_341_residues
MNFDRTFVLGASMAEKSFNLYRYSIPVDSQLILRDRFLKRREGLIVRVSCSRDGWGEIAPLPGFSEETLDQAQEQAIEWL
TTWCNASCDAPRVPLDGTYPSVAFGISCAMDEMKGYLQAEGNYHTAPLCYGDPDELYAKLASMEGEKVAKMKVGIYEANR
DGLIADMFLEAIPDLQLRLDANRHWSLEKALQFAAKVKLQHRKRIQFLEEPCKTQALSREFAVQTDIAIAWDESVREPNF
CLEKEPHLSAVVIKPTLIGSIQRCTELINQAHSLGLKAVISSSIESSLGLSQLARIAQQYTPNVTPGLDTLDLMEYQVLR
AWPSSDLPIVDLESEFITKII

Specific function: Converts SHCHC to OSB [H]

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788596, Length=320, Percent_Identity=56.25, Blast_Score=364, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013342
- InterPro:   IPR010196 [H]

Pfam domain/function: PF01188 MR_MLE [H]

EC number: =4.2.1.113 [H]

Molecular weight: Translated: 38310; Mature: 38310

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDRTFVLGASMAEKSFNLYRYSIPVDSQLILRDRFLKRREGLIVRVSCSRDGWGEIAP
CCCCCEEEEECHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
LPGFSEETLDQAQEQAIEWLTTWCNASCDAPRVPLDGTYPSVAFGISCAMDEMKGYLQAE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEC
GNYHTAPLCYGDPDELYAKLASMEGEKVAKMKVGIYEANRDGLIADMFLEAIPDLQLRLD
CCEEECCEECCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEC
ANRHWSLEKALQFAAKVKLQHRKRIQFLEEPCKTQALSREFAVQTDIAIAWDESVREPNF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCC
CLEKEPHLSAVVIKPTLIGSIQRCTELINQAHSLGLKAVISSSIESSLGLSQLARIAQQY
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TPNVTPGLDTLDLMEYQVLRAWPSSDLPIVDLESEFITKII
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHCC
>Mature Secondary Structure
MNFDRTFVLGASMAEKSFNLYRYSIPVDSQLILRDRFLKRREGLIVRVSCSRDGWGEIAP
CCCCCEEEEECHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
LPGFSEETLDQAQEQAIEWLTTWCNASCDAPRVPLDGTYPSVAFGISCAMDEMKGYLQAE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEC
GNYHTAPLCYGDPDELYAKLASMEGEKVAKMKVGIYEANRDGLIADMFLEAIPDLQLRLD
CCEEECCEECCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEC
ANRHWSLEKALQFAAKVKLQHRKRIQFLEEPCKTQALSREFAVQTDIAIAWDESVREPNF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCC
CLEKEPHLSAVVIKPTLIGSIQRCTELINQAHSLGLKAVISSSIESSLGLSQLARIAQQY
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TPNVTPGLDTLDLMEYQVLRAWPSSDLPIVDLESEFITKII
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]