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The map label for this gene is menA

Identifier: 30995381

GI number: 30995381

Start: 525211

End: 526122

Strand: Reverse

Name: menA

Synonym: HI0509

Alternate gene names: 30995381

Gene position: 526122-525211 (Counterclockwise)

Preceding gene: 16272455

Following gene: 16272452

Centisome position: 28.75

GC content: 38.6

Gene sequence:

>912_bases
ATGATAAATGAAAAATTGAAAATGTGGTGGGAAACGGCTCGACCAAAAACTTTGCCATTAGCGTTGGCATCGATTTTCAC
GGGTTCGGCATTAGGTTATTGGGCGAATCCACAAGGTTTTAATGGGCTTGTAATGGTGCTTTGTTTACTCACGACAATTT
TATTGCAGGTGCTTTCTAATTTTGCCAATGATTATGGGGATCATCAAAAAGGTTCAGATACTGAAGAACGTATTGGGCCA
TTACGTGGCATTCAAAAAGGCGCAATTTCAGCAAAAGAACTGAAATGGGGATTAATCCTAATGGTGATGGCAAGTTTTCT
TTCAGGAAGTTTCTTGATTGGAATCGCTTATGAAAATCTCTCAGATTTATTCGCTTTCGCTGGGCTTGGAATTTTAGCTA
TTGTTGCTGCCATTACTTACACAGTTGGGGTAAAACCTTATGGCTATATGGGCTTGGGCGATATTTCTGTATTGGTATTT
TTTGGTTTGCTTGGTGTTGGCGGTACTTATTATTTGCAAACTCACAGTATTGATAGCCACATTATTTTGCCTGCTATTGG
TTCTGGCTTATTGGCAAGTGCGGTATTAAATATCAATAATTTACGCGATATTGAACAGGATGCGAAAGCTGGCAAAAATA
CCCTAGCCGTTCGTTTAGGTGCATATAAAGGGCGTGTTTATCATTGTATTTTATTAAGTGTGGCGGCCCTATGTTATTTA
GCATTTGCGGTGGCAACGGCTATTTCTTGGACAAATTATTTATTTGTATTAGCAATGCCGTTGTTAGCTAAACATGCGAT
CTTTGTTTATTGCAGTCAGCAGCCAAGTGAATTGCGTCCAATATTGGCTCAAATGTCTATGATTTCGTTATTAATCAATA
TCTTGTTTAGTTTAGGCTTGCTTATCGGCTAA

Upstream 100 bases:

>100_bases
GTGGATAATGGCGATAGGCGATAAGGTTAAATCATTCATAAATTGGGTGTCTTAGTGTAGAATACGCGGCTTATTGTAAT
CAAAAGTGCGGTCAAAAAAA

Downstream 100 bases:

>100_bases
ATCGGCATATACTAAAGCAAACAAAATTTCAACAATCGATAGGGGAAAGTTATGTTTATTGATACTTCAGAACTTTGCGA
TCTTTATGCAGAACAAGTGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGP
LRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVF
FGLLGVGGTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
AFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGLLIG

Sequences:

>Translated_303_residues
MINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGP
LRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVF
FGLLGVGGTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
AFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGLLIG
>Mature_303_residues
MINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSNFANDYGDHQKGSDTEERIGP
LRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVF
FGLLGVGGTYYLQTHSIDSHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
AFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGLLIG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family

Homologues:

Organism=Homo sapiens, GI7019551, Length=305, Percent_Identity=25.9016393442623, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=52.3333333333333, Blast_Score=289, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17737429, Length=234, Percent_Identity=29.9145299145299, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENA_HAEIN (P44739)

Other databases:

- EMBL:   L42023
- PIR:   H64153
- RefSeq:   NP_438667.2
- GeneID:   949923
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0509
- NMPDR:   fig|71421.1.peg.480
- TIGR:   HI_0509
- HOGENOM:   HBG313998
- OMA:   YLGLGDV
- ProtClustDB:   PRK06080
- BioCyc:   HINF71421:HI_0509-MONOMER
- InterPro:   IPR004657
- InterPro:   IPR000537
- TIGRFAMs:   TIGR00751

Pfam domain/function: PF01040 UbiA

EC number: =2.5.1.74

Molecular weight: Translated: 32715; Mature: 32715

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc553308)-; HASH(0xccf0d64)-; HASH(0xc0754bc)-; HASH(0xc3ae290)-; HASH(0xc7e3e50)-; HASH(0xcd9f6dc)-; HASH(0xafc88bc)-; HASH(0xcb99bfc)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSN
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENL
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
SDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIDSH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCE
IILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
EEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIG
HCH
>Mature Secondary Structure
MINEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMVLCLLTTILLQVLSN
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENL
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
SDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIDSH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCE
IILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
EEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AFAVATAISWTNYLFVLAMPLLAKHAIFVYCSQQPSELRPILAQMSMISLLINILFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIG
HCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800