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The map label for this gene is wecA

Identifier: 16273603

GI number: 16273603

Start: 1788088

End: 1789155

Strand: Reverse

Name: wecA

Synonym: HI1716

Alternate gene names: 16273603

Gene position: 1789155-1788088 (Counterclockwise)

Preceding gene: 16273604

Following gene: 16273601

Centisome position: 97.76

GC content: 37.45

Gene sequence:

>1068_bases
ATGCTGAGTATTTTTGTTACTTTTCTTGGCGCGTTTTTAACATTGATTGTGATGCGACCACTTGCCAATTGGATTGGATT
AGTCGATAAACCAAACTATCGTAAACGTCATCAAGGCACAATTCCACTAATCGGTGGCGCATCGCTTTTTGTTGGTAATC
TTTGCTATTATCTGATGGAATGGGATCAACTTCGATTACCGTATCTTTATTTGTTCAGTATTTTTGTTTTATTGGCGATT
GGGATTTTAGATGATCGCTTTGATATTAGCCCTTTTTTAAGAGCAGGCATTCAAGCAATATTGGCGATTTTAATGATCGA
TCTTGGGAATATTTATCTTGATCATCTTGGTCAAATTTTAGGGCCTTTCCAATTAACGCTTGGTTCAATTGGTTTGATTA
TTACCGTCTTTGCCACTATTGCGATTATTAATGCCTTTAATATGATTGATGGTATTGATGGATTGCTTGGGGGACTCTCT
TGTGTTTCTTTTGCGGCGATTGGTATTTTAATGTATCGAGATGGGCAAATGGATATGGCGCATTGGAGTTTTGCTTTAAT
CGTATCGATTTTACCTTATTTGATGCTCAATCTAGGGATTCCATTTGGACCAAAATATAAGGTGTTTATGGGGGATGCCG
GGAGTACATTAATTGGCTTTACCATTATTTGGATTTTGTTATTAAGTACGCAAGGAAAAGGGCATCCTATGAATCCAGTA
ACCGCACTTTGGATTATTGCGATTCCTTTGATTGATATGGTTGCGATTATTTATCGCCGTGTACGTAAAGGTAAAAGCCC
ATTCCGTCCAGATCGTTTACATGTTCATCATTTAATGGTAAGAGCGGGTTTAACATCAAGACAAGCCTTTTTATTGATTA
CGTTTGTTTCTGCAGTTTGTGCAACTATCGGTATTTTAGGGGAAGTTTATTATGTGAATGAGTGGGCGATGTTTGTTGGC
TTTTTCATTTTATTTTTCCTTTATGTCTATTCAATTACGCATGCATGGCGAATTACCCGTTGGGTAAGAAGAATGAAACG
TCGTGCCAAACGGTTGAAGAAAGCATAA

Upstream 100 bases:

>100_bases
AAATACGGGCGTTGAAGTGAAAAATAGGGCTTCGTTAAAAATATATTTCTAGGTAAATTTGCCTTATGTTATCCTTTACA
AAAAATTTTAGGGTCACACT

Downstream 100 bases:

>100_bases
AAAAATAAAGGCTTGTGTTATTAAATCACAAGCCTTTATTTTTTGAGAAAATTCACCGCACTTTTTAAGATTTTGGTGAT
CTATTTTTGTAGATAGAAAA

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGASLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA

Sequences:

>Translated_355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGASLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
>Mature_355_residues
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGASLFVGNLCYYLMEWDQLRLPYLYLFSIFVLLAI
GILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQILGPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLS
CVSFAAIGILMYRDGQMDMAHWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVCATIGILGEVYYVNEWAMFVG
FFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily

Homologues:

Organism=Escherichia coli, GI1790218, Length=328, Percent_Identity=60.3658536585366, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECA_HAEIN (P45341)

Other databases:

- EMBL:   L42023
- PIR:   A64138
- RefSeq:   NP_439858.1
- GeneID:   950539
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1716
- NMPDR:   fig|71421.1.peg.1629
- TIGR:   HI_1716
- HOGENOM:   HBG536396
- OMA:   IPLIDMI
- ProtClustDB:   CLSK870116
- BioCyc:   HINF71421:HI_1716-MONOMER
- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- TIGRFAMs:   TIGR02380

Pfam domain/function: PF00953 Glycos_transf_4

EC number: 2.7.8.- [C]

Molecular weight: Translated: 40071; Mature: 40071

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xec5bebc)-; HASH(0xe82d704)-; HASH(0xca478ec)-; HASH(0xe0baf0c)-; HASH(0xed11728)-; HASH(0xf041c50)-; HASH(0xf06399c)-; HASH(0xe90027c)-; HASH(0xecb84f8)-; HASH(0xf05a6b0)-; HASH(0xf06675c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGASLFVGNLCYYLME
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEECCHHHHHHHHHHHHHH
WDQLRLPYLYLFSIFVLLAIGILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQIL
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLSCVSFAAIGILMYRDGQMDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
HWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATIGILGEVYYVNEWAMFVGFFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLSIFVTFLGAFLTLIVMRPLANWIGLVDKPNYRKRHQGTIPLIGGASLFVGNLCYYLME
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEECCHHHHHHHHHHHHHH
WDQLRLPYLYLFSIFVLLAIGILDDRFDISPFLRAGIQAILAILMIDLGNIYLDHLGQIL
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPFQLTLGSIGLIITVFATIAIINAFNMIDGIDGLLGGLSCVSFAAIGILMYRDGQMDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
HWSFALIVSILPYLMLNLGIPFGPKYKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPV
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TALWIIAIPLIDMVAIIYRRVRKGKSPFRPDRLHVHHLMVRAGLTSRQAFLLITFVSAVC
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ATIGILGEVYYVNEWAMFVGFFILFFLYVYSITHAWRITRWVRRMKRRAKRLKKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800