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The map label for this gene is folP-2

Identifier: 16273369

GI number: 16273369

Start: 1548042

End: 1548869

Strand: Reverse

Name: folP-2

Synonym: HI1464

Alternate gene names: 16273369

Gene position: 1548869-1548042 (Counterclockwise)

Preceding gene: 16273370

Following gene: 16273368

Centisome position: 84.63

GC content: 39.37

Gene sequence:

>828_bases
ATGAAACTTTACGCAAATAATAAATGTCTTGATTTAAGCGTGCCTCAAATTATGGGGATTCTTAATTTTACGCCTGATTC
TTTTTCTGATAGCGGACAGTTTTTTAGTCTAGATAAAGCACTTTTTCAAGTTGAAAAAATGCTAGAAGAGGGGGCGACAA
TTATTGATATTGGTGGAGAATCCACTCGTCCGAATGCGGATGAAGTTTCTGAACAAGAGGAATTGCATCGTGTTGTGCCA
GTAGTGGAGGCGGTGCGAAACCGTTTTGATTGCTGGATTTCTGTTGATTCCTCAAAAGCTGTTGTGATGCGTGAAGCGGC
AAATGTTGGAATGGATTTGATTAATGATATTCGTGCTTTGCAAGAGCCGAATGCGTTAGAAACGGCGGTAAAACTGGCTT
TACCTGTTTGTATTATGCATATGCAAGGGCAACCTCGCACGATGCAAGCAAATCCTTATTATGAAAATGTCGTGCAAGAT
GTATTGGCTTTTTTACAAAAACGTACTAATGAATGCCTTTCTGCTGGCATTAAAAAAGAAAATTTAATTTGGGATATGGG
CTTTGGCTTTGGCAAATCTGTACAGCATAATTATCAATTATTACAAAATCTGAATGAATTTTGTCAGATAGGTTATCCCG
TATTAGCAGGGTTATCTCGCAAATCAATGATTGGCGCAGTGCTTGATAAACCTGTTGATCAAAGAATAATTGGCAGTGCG
GCAGGTGCGCTTATTGCAGTGCAAAAAGGTGCAAAAATTTTACGCGTACATGATGTTGCTGCAACATCAGATATGCTCAA
AGTTTGGCAGGCAACAGCAAATGCCTGA

Upstream 100 bases:

>100_bases
CTTTCTTCGGAAAGGCTTTATTTTTTCCTAATGATTTTGTTCTTGGATGTATTTCGCTATAATCGCCCACCAAAATCACT
CTAAAAATTAACCGCATTTT

Downstream 100 bases:

>100_bases
TGGTTTTATAACGATAAAAAATTAAAGGAATTTTATTATGGCAAATCGTAAATATTTTGGAACAGATGGTGTACGTGGAA
AAGTAGGTGCTTACCCAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVVP
VVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA

Sequences:

>Translated_275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVVP
VVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
>Mature_275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVVP
VVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=275, Percent_Identity=54.5454545454545, Blast_Score=305, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=28.0373831775701, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHPS_HAEIN (P43776)

Other databases:

- EMBL:   L42023
- EMBL:   L42023
- PIR:   E64117
- RefSeq:   NP_439487.1
- RefSeq:   NP_439615.1
- ProteinModelPortal:   P43776
- SMR:   P43776
- GeneID:   950351
- GeneID:   950701
- GenomeReviews:   L42023_GR
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1336
- KEGG:   hin:HI1464
- TIGR:   HI_1336
- TIGR:   HI_1464
- HOGENOM:   HBG754410
- OMA:   NANEDSF
- ProtClustDB:   CLSK870099
- BioCyc:   HINF71421:HI_1336-MONOMER
- BioCyc:   HINF71421:HI_1464-MONOMER
- BRENDA:   2.5.1.15
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496

Pfam domain/function: PF00809 Pterin_bind; SSF51717 DHP_synth_like

EC number: =2.5.1.15

Molecular weight: Translated: 30330; Mature: 30330

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS50972 PTERIN_BINDING

Important sites: BINDING 30-30 BINDING 96-96 BINDING 115-115 BINDING 185-185 BINDING 221-221 BINDING 255-255 BINDING 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGE
CEEECCCCEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCC
STRPNADEVSEQEELHRVVPVVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHH
QEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKE
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSA
CEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
HHHHEEHHCCCEEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGE
CEEECCCCEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCC
STRPNADEVSEQEELHRVVPVVEAVRNRFDCWISVDSSKAVVMREAANVGMDLINDIRAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHH
QEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKE
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLIWDMGFGFGKSVQHNYQLLQNLNEFCQIGYPVLAGLSRKSMIGAVLDKPVDQRIIGSA
CEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHH
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
HHHHEEHHCCCEEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800