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The map label for this gene is trpA [H]

Identifier: 16273337

GI number: 16273337

Start: 1520404

End: 1521210

Strand: Direct

Name: trpA [H]

Synonym: HI1432

Alternate gene names: 16273337

Gene position: 1520404-1521210 (Clockwise)

Preceding gene: 16273336

Following gene: 16273339

Centisome position: 83.08

GC content: 42.38

Gene sequence:

>807_bases
ATGAGCCGTTTTGAAACGCAATTTGCGACACTTAACGCAAAAAATGAAGGGGCCTTCGTGCCGTTCGTTACCCTTTGCGA
CCCTACTTTCGACCGCTCTTTTGAGATCATTTGCACACTTGTGGATAACGGTGCAGATGCTTTAGAACTCGGTTTTCCTT
TTTCCGATCCGCTACTCGATGGCCCAGTTATTCAAGCCGCGAATAATCGTGCTTTAACTGCAGGTCATAGCAGCGAAGAT
AGCTTGAAACTATTGGAAAAAGTGCGGTCAAAATATCCAGAGATTCCGATTAGCTTATTACTTTGTGCCAATTTAATTTT
TGCTAAAGGTTTAGATGCTTTTTATCAACGTTGTGCAGAAGTTGGTGTTGATGCTGTACTTGTAGCAGATATTCCGTTAC
TGGCAAAAGGAGATTATGTACAAACAGCTAAAAAACACGGTATTCAACCCGTCTTTATTTGCCCACCAAATGCGGACGAG
AAAACGATCCAAGGCGTAGCGAAAAATAGCGAAGGCTATACCTATTTAGTCTCACGTGCAGGCGTAACCAGTGCTGAAAA
TCAAGCTCACGCAGCAAATTTAGATACCCTTGTAGAAAAGCTTAAAGCCCACAATGCCCCACCAATTTTACAAGGCTTCG
GCATTGCTCAACCAGAGCAAGTTAAAGAAGCGTTGTCTTTGGGCACTGCGGGTGCAATTTCAGGTTCGGCAACGGTGAAA
ATTATTGAGCGAAATTTAGATAATCACGAGCAATGTTTAGCTGAATTAGCTGAATTTGTTCAAACGATGAAAGCTGCAAC
AAAATAA

Upstream 100 bases:

>100_bases
AAAATCCTGAAAAAGAACAACTTTTAGTGGTTAATCTTTCAGGACGAGGCGATAAAGATATTTTTACCGTTGATAAAATT
TTAAATGGAGGAGCAAACTA

Downstream 100 bases:

>100_bases
GCAAAAAAGAACCCGCACTTGTGGCGGGTTTCTTTTATCGAGAAAATTAAAAATTTAATACTTTCAGCTTCCATCCACCA
TAAGGGGCTGAATGGATTAT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLDGPVIQAANNRALTAGHSSED
SLKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAEVGVDAVLVADIPLLAKGDYVQTAKKHGIQPVFICPPNADE
KTIQGVAKNSEGYTYLVSRAGVTSAENQAHAANLDTLVEKLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVK
IIERNLDNHEQCLAELAEFVQTMKAATK

Sequences:

>Translated_268_residues
MSRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLDGPVIQAANNRALTAGHSSED
SLKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAEVGVDAVLVADIPLLAKGDYVQTAKKHGIQPVFICPPNADE
KTIQGVAKNSEGYTYLVSRAGVTSAENQAHAANLDTLVEKLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVK
IIERNLDNHEQCLAELAEFVQTMKAATK
>Mature_267_residues
SRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLDGPVIQAANNRALTAGHSSEDS
LKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAEVGVDAVLVADIPLLAKGDYVQTAKKHGIQPVFICPPNADEK
TIQGVAKNSEGYTYLVSRAGVTSAENQAHAANLDTLVEKLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVKI
IERNLDNHEQCLAELAEFVQTMKAATK

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=268, Percent_Identity=56.3432835820896, Blast_Score=288, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6321412, Length=238, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28731; Mature: 28600

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLD
CCCHHCHHEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCC
GPVIQAANNRALTAGHSSEDSLKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAE
CCEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
VGVDAVLVADIPLLAKGDYVQTAKKHGIQPVFICPPNADEKTIQGVAKNSEGYTYLVSRA
HCCCEEEEECCCEECCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECC
GVTSAENQAHAANLDTLVEKLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVK
CCCCCCCCHHHCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
IIERNLDNHEQCLAELAEFVQTMKAATK
EEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRFETQFATLNAKNEGAFVPFVTLCDPTFDRSFEIICTLVDNGADALELGFPFSDPLLD
CCHHCHHEEECCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCEEEECCCCCCCCCC
GPVIQAANNRALTAGHSSEDSLKLLEKVRSKYPEIPISLLLCANLIFAKGLDAFYQRCAE
CCEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
VGVDAVLVADIPLLAKGDYVQTAKKHGIQPVFICPPNADEKTIQGVAKNSEGYTYLVSRA
HCCCEEEEECCCEECCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECC
GVTSAENQAHAANLDTLVEKLKAHNAPPILQGFGIAQPEQVKEALSLGTAGAISGSATVK
CCCCCCCCHHHCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEE
IIERNLDNHEQCLAELAEFVQTMKAATK
EEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA