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The map label for this gene is ddc

Identifier: 16272884

GI number: 16272884

Start: 1006630

End: 1008165

Strand: Reverse

Name: ddc

Synonym: HI0946.1

Alternate gene names: 16272884

Gene position: 1008165-1006630 (Counterclockwise)

Preceding gene: 16272885

Following gene: 16272883

Centisome position: 55.09

GC content: 42.06

Gene sequence:

>1536_bases
ATGTCAAACCTCAAACAACACAAACAAGCTTTGTTTTGCAACGATAACGAAGCCATTAACGATTATGAAACAGCGATGCA
TAATGCGGTGCAAGCAGTCTCTGCTTGGCTGAAAAATGAAAAAATGTACACAGGCGGTTCAATCAAACAAATGCGAGCCT
TAATAAGCGGTTTTAATCCGACGAAAGAGGGTATGGGTGTACAGAAATCACTCGATCATTTGGTAGAAATTTTCCTTAAT
CCAAGCCTTAAAGTACATCATCCACACTCACTTGCCCATTTACATTGCCCAACGATGGTAACAAGCCAAATTGCGGAAGT
ACTGATTAATGCGACCAACCAATCAATGGATTCTTGGGATCAAAGCCCAGCAGGTTCAATTATGGAGGAGCATTTGATCA
ACTGGCTACGCCAAAAAGCAGGCTATGGCGAAGGCACATCAGGCGTGTTCACTTCTGGTGGTACTCAATCTAACTTAATG
GGCGTATTGTTGGCACGCGATTGGGCGATTGCAAACCACTGGAAAAACGAAGACGGCTCTGAATGGTCAGTACAACGTGA
TGGTATTCCAGCAGAAGCGATGCAAAAAGTGAAAGTGATTTGTTCAGAAAACGCACATTTCTCTGTACAAAAAAATATGG
CAATGATGGGAATGGGTTTCCAATCAGTCGTTACTGTGCCATCAAATGCCAATGCACAAATGGATCTTATTGCACTTAAA
CAAACACTTGCACAGCTTAAAGCTGATGGCAAAATTACTGCCTGTATTGTTGCTACCGCAGGCACAACAGATGCTGGCGC
AATTGATGACTTAAAAGCAATCCGCAAACTTGCCGATGAATATCAAGCGTGGTTACACGTTGATGCCGCTTGGGGTGGCG
CATTATTGCTTTCCAAAGATTATCGCTATTTCTTAGATGGTATTGAATTAACTGATTCCATCACGCTTGATTTCCACAAA
CACTTCTTCCAAACCATTTCCTGTGGTGCATTTTTACTCAAGGATCCAGAGAACTATCGCTTTATCGATTACAAAGCGGA
TTATCTCAATTCGGAATATGATGAAGCTCACGGCGTGCCAAACTTAGTGGCGAAATCATTACAAACCACACGTCGTTTCG
ACGCATTAAAATTATGGTTTACCCTTGAAGCATTGGGCGAAGATCTTTACGCTTCAATGATCGATCACGGCGTAAAACTG
ACCAAAGAAGTCGAGCAATACATCAACGATACCCCTGACTTAGAAATGCTTGTGCCAAGTCAGTTTGCATCGGTGTTATT
CCGTGTCGTACCAAAAGACTATCCAGCTGAATTTATTGATGCACTAAACCAAAACGTGGCAGATGAACTCTTTGCTCGAG
GAGAAGCGAATATTGGCGTGACTAAAGTAGGCGACAAACAATCGCTGAAAATGACTACCCTAAGCCCGATTGCAACATTG
GAAAATGTTAAAGCGTTATTAACTCAAGTACTAACAGAAGCAAATCGTATTAAAGACGACATCAAAAATGGCACTTACAC
ACCACCCATTGATTAA

Upstream 100 bases:

>100_bases
AGTGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTA
ATTCATATCTAGGAATAATT

Downstream 100 bases:

>100_bases
TTAGTTAGTCAATTAACACAAAAAAATAACCGCTTGTATCTGAAAACAGGCGGTTATTCTGTAAAATAAAAATCTTTTAG
CATAGATCAAACGAGATATA

Product: L-24-diaminobutyrate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNPTKEGMGVQKSLDHLVEIFLN
PSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLM
GVLLARDWAIANHWKNEDGSEWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALK
QTLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKDYRYFLDGIELTDSITLDFHK
HFFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKL
TKEVEQYINDTPDLEMLVPSQFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
ENVKALLTQVLTEANRIKDDIKNGTYTPPID

Sequences:

>Translated_511_residues
MSNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNPTKEGMGVQKSLDHLVEIFLN
PSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLM
GVLLARDWAIANHWKNEDGSEWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALK
QTLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKDYRYFLDGIELTDSITLDFHK
HFFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKL
TKEVEQYINDTPDLEMLVPSQFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
ENVKALLTQVLTEANRIKDDIKNGTYTPPID
>Mature_510_residues
SNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNPTKEGMGVQKSLDHLVEIFLNP
SLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLMG
VLLARDWAIANHWKNEDGSEWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALKQ
TLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKDYRYFLDGIELTDSITLDFHKH
FFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKLT
KEVEQYINDTPDLEMLVPSQFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATLE
NVKALLTQVLTEANRIKDDIKNGTYTPPID

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family

Homologues:

Organism=Homo sapiens, GI194294551, Length=369, Percent_Identity=29.5392953929539, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI197383062, Length=472, Percent_Identity=25.8474576271186, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI197276620, Length=429, Percent_Identity=26.3403263403263, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI4503875, Length=429, Percent_Identity=26.3403263403263, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI58331246, Length=428, Percent_Identity=25.2336448598131, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4503281, Length=408, Percent_Identity=25.2450980392157, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI132814448, Length=408, Percent_Identity=25.2450980392157, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI92110055, Length=424, Percent_Identity=25, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71993062, Length=438, Percent_Identity=26.7123287671233, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=438, Percent_Identity=26.7123287671233, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71993058, Length=368, Percent_Identity=26.6304347826087, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534819, Length=420, Percent_Identity=24.2857142857143, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17534817, Length=420, Percent_Identity=24.2857142857143, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71981211, Length=455, Percent_Identity=21.978021978022, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71981217, Length=464, Percent_Identity=21.3362068965517, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17551992, Length=467, Percent_Identity=20.3426124197002, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI133931025, Length=393, Percent_Identity=21.6284987277354, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136594, Length=438, Percent_Identity=26.9406392694064, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356415, Length=333, Percent_Identity=30.9309309309309, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24657193, Length=362, Percent_Identity=29.0055248618785, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24657185, Length=362, Percent_Identity=29.0055248618785, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24657188, Length=362, Percent_Identity=29.0055248618785, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17136190, Length=352, Percent_Identity=26.1363636363636, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585135, Length=334, Percent_Identity=26.3473053892216, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585139, Length=423, Percent_Identity=24.5862884160757, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221476190, Length=423, Percent_Identity=24.5862884160757, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585143, Length=423, Percent_Identity=24.5862884160757, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24652373, Length=404, Percent_Identity=24.7524752475248, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586044, Length=421, Percent_Identity=24.2280285035629, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573972, Length=431, Percent_Identity=23.2018561484919, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDC_HAEIN (P71362)

Other databases:

- EMBL:   L42023
- PIR:   JC5880
- RefSeq:   NP_439107.1
- ProteinModelPortal:   P71362
- SMR:   P71362
- GeneID:   950216
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0946.1
- NMPDR:   fig|71421.1.peg.913
- TIGR:   HI_0946.1
- HOGENOM:   HBG708517
- OMA:   DFHKHFF
- ProtClustDB:   CLSK892388
- BioCyc:   HINF71421:HI_0946.1-MONOMER
- BRENDA:   4.1.1.86
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11999

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.86

Molecular weight: Translated: 56639; Mature: 56508

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNP
CCCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
TKEGMGVQKSLDHLVEIFLNPSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWD
CHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHEECHHHHHHHHHHHHHHHCCCCHHHCC
QSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLMGVLLARDWAIANHWKNEDGS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALK
CCEEECCCCCHHHHHHHHHHHCCCCCEEHHCCHHHHCCCHHHEEECCCCCCCCHHHHHHH
QTLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKD
HHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECC
YRYFLDGIELTDSITLDFHKHFFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVP
HHHHHCCCCCCCCEEHHHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHCCCCHHHHCCCH
NLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKLTKEVEQYINDTPDLEMLVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHH
QFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCHHHHH
ENVKALLTQVLTEANRIKDDIKNGTYTPPID
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNLKQHKQALFCNDNEAINDYETAMHNAVQAVSAWLKNEKMYTGGSIKQMRALISGFNP
CCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
TKEGMGVQKSLDHLVEIFLNPSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWD
CHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHEECHHHHHHHHHHHHHHHCCCCHHHCC
QSPAGSIMEEHLINWLRQKAGYGEGTSGVFTSGGTQSNLMGVLLARDWAIANHWKNEDGS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EWSVQRDGIPAEAMQKVKVICSENAHFSVQKNMAMMGMGFQSVVTVPSNANAQMDLIALK
CCEEECCCCCHHHHHHHHHHHCCCCCEEHHCCHHHHCCCHHHEEECCCCCCCCHHHHHHH
QTLAQLKADGKITACIVATAGTTDAGAIDDLKAIRKLADEYQAWLHVDAAWGGALLLSKD
HHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECC
YRYFLDGIELTDSITLDFHKHFFQTISCGAFLLKDPENYRFIDYKADYLNSEYDEAHGVP
HHHHHCCCCCCCCEEHHHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHCCCCHHHHCCCH
NLVAKSLQTTRRFDALKLWFTLEALGEDLYASMIDHGVKLTKEVEQYINDTPDLEMLVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHH
QFASVLFRVVPKDYPAEFIDALNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCHHHHH
ENVKALLTQVLTEANRIKDDIKNGTYTPPID
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614