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The map label for this gene is kefC

Identifier: 16272848

GI number: 16272848

Start: 965021

End: 966877

Strand: Direct

Name: kefC

Synonym: HI0911

Alternate gene names: 16272848

Gene position: 965021-966877 (Clockwise)

Preceding gene: 16272847

Following gene: 16272849

Centisome position: 52.73

GC content: 37.53

Gene sequence:

>1857_bases
ATGTCTCAACTTGCCAATCCAGAACTGATGAAAGTCGTTATTTTACTCGCATCTAGCGTAACAATTGTGCCGTTATTTAA
AAGACTCGGGTTGGGTAGCGTGCTAGGTTATTTAGTGGCAGGTTGTTTGATTGGCCCATCTGTCTTTGGCATAGTGCAAG
AACCAACAGCTGTGGTACATTTAGCGGAATTAGGTGTGGTAATGTTTCTTTTTATTATCGGGCTTGAAATGTATCCAGAA
CGCCTTTGGGCAATGCGTAAAGCTATTTTTGGTAGAGGTTTGTTACAAGTTGGATTATGTGGTTGCTTACTCACTTTTTC
GGGTATTTATTTATTAGGATTAACAAAAGAAGTATCATTTATCGCTGGTATGGGTTTCACGCTTTCCTCTACTGCTATTG
TAATGCAATCACTAGAAGAAAGGGGGCTTACTTCTACGTCAAAAGGACAACGCGTAATTTCGACATTAATTTTTGAAGAT
ATTGCTATTGTACCACTTTTGGCTTCTGTCGCTTTTCTTGCTCCCCATTCGAAAGAAGCGACACCACATACTGATTGGGT
ATCAATTGGTATAGCATTAAGTGCTGTTGTGGGGTTAATTGTGACTGGAAAATGGCTAATGAACCCACTATTTCGTTTAA
TTTCTAAAGCACGTATTCGTGAAATGATGACAGCGGGCGCATTATTGGTCGTTTTAGGTGCTGCATTAGCAATGGAAATT
GGCGGACTTTCAATGGCAATGGGCGCGTTTGTTGCTGGTGTGATGATGTCTGAATCAGCGTTTCGCCATCAGCTTGAAGC
GGATATAGAACCATTTCGCGGCTTATTACTAGGATTATTTTTTATGGGCGTAGGAATGTCCTTAGATTTGCATTTAGTGT
TTAATCATTGGATCTTGCTACTTGGAATTGTTTTTCTTTATATACTTGGAAAAGCCAGTGCTGTTTATATTATTGCCCGA
ATTACCCGTCTTGATCATCGAGAAGCCATAGGACGAATGTCTTTGATGGCACACGGTGGCGAATTTGCTTTCGTTCTTTT
TTCAGCTGCAGCAACTGCGGAAGTAATCAGTAATGAAGAACAAGCGACATTCACTGCTGCAGTGATTATTTCGATGCTTT
TTTCGCCTATTATTGCTCAAATTGCTCGTAAACTTATACAGCGTACAGAGCCTAAACATCTTGATCAACTTGATGAAAAT
GATCTAGACACCATCGTGGATTTGGAAGATAACGTTTTAGTTATTGGTTTTGGACGTTTTAGTCAAATTGTCTGCCAAAC
ATTATTAATTCGTGGAATTAGCGTTTCAGTGATTGATCGCAATATCGAAAATATCCGTGCTGCCGCAAAGTTTGGTTTTA
AAGTTTATTATGGCGATGGCATTCGATTAGATGTTTTACGAGCCGCAGGAATTGAAAAGGCGAAATGTGTCGTATTAGGT
ATTAACGATACACAAAGAATTGAACATATTGTCAGTCAAATGAAAGAGGCTTATCCAAATTTACCGATTTTAACCCGAAC
TTATGACAGAAAAACAACAGTTAGTTTGATTAAGCAGGATGTAGATTTTATTGTGCGTGAAACTTTTGAATCAGCAATTA
CACTTAGTCGAGCAACATTGATGAAATTAGGTATTGATAAAATTGAAGCGGAAGAAATTATTAAGGAAGTACGAACATTG
GATCAAGAACGGTTAAATGAAGAAGTTTTACACGGTTTTTCGAATGAAATAGTAAAAAAATATTGGACACCAAGACCATT
TATTAAACCGCATCTTGATACAAAAGCATTAAATAAAGAAACAGAAGAAATTCTAAGTGAGAAAATTGAAGAAGAAATAT
CAAATGATCATTCATAA

Upstream 100 bases:

>100_bases
TGGTTTAAAGTTATATTAAAAGATTTAGTATGATTTATCACATATAACTTTTTAATATACTCGCCAAAATATTTGTATTT
TTTGCATTATTGGAGTCATT

Downstream 100 bases:

>100_bases
AATTATTTTTTATCTATAAAAATATTAAATTTTAACTTCTCGTTTAAGTATTTACTTTTGAGTGATTTAAATCACGTAAA
TTTTTATTTTAAGGCAATAA

Product: glutathione-regulated potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVHLAELGVVMFLFIIGLEMYPE
RLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFED
IAIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIAR
ITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEN
DLDTIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTL
DQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS

Sequences:

>Translated_618_residues
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVHLAELGVVMFLFIIGLEMYPE
RLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFED
IAIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIAR
ITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEN
DLDTIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTL
DQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS
>Mature_617_residues
SQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVHLAELGVVMFLFIIGLEMYPER
LWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDI
AIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEIG
GLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIARI
TRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEND
LDTIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLGI
NDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTLD
QERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain

Homologues:

Organism=Homo sapiens, GI157388921, Length=400, Percent_Identity=26.5, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786232, Length=611, Percent_Identity=38.6252045826514, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789749, Length=607, Percent_Identity=36.2438220757825, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1786685, Length=521, Percent_Identity=25.7197696737044, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KEFX_HAEIN (P44933)

Other databases:

- EMBL:   L42023
- PIR:   A64102
- RefSeq:   NP_439071.1
- ProteinModelPortal:   P44933
- GeneID:   950431
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0911
- NMPDR:   fig|71421.1.peg.877
- TIGR:   HI_0911
- HOGENOM:   HBG428809
- OMA:   MSHGGEF
- ProtClustDB:   CLSK892386
- BioCyc:   HINF71421:HI_0911-MONOMER
- GO:   GO:0005488
- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00932

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N

EC number: NA

Molecular weight: Translated: 68078; Mature: 67947

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS51201 RCK_N

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd2ecba0)-; HASH(0xda3f010)-; HASH(0xd75072c)-; HASH(0xd9b26dc)-; HASH(0xb9c434c)-; HASH(0xb22eba4)-; HASH(0xda5b5d8)-; HASH(0xc59bd98)-; HASH(0xb459570)-; HASH(0xd88d98c)-; HASH(0xd773130)-; HASH(0xb22ebbc)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVH
CCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAELGVVMFLFIIGLEMYPERLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDIAIVPLLASVAFLAPHSKEA
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
LGIVFLYILGKASAVYIIARITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCH
QATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDENDLDTIVDLEDNVLVIGFGRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEECCCCEEEEECCHH
SQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCEEEEECCCCEEEHHHHCCCCCCCEEEEE
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATL
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKLGIDKIEAEEIIKEVRTLDQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TEEILSEKIEEEISNDHS
HHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
SQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQEPTAVVH
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH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HHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800