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The map label for this gene is mutT

Identifier: 16272847

GI number: 16272847

Start: 964502

End: 964912

Strand: Direct

Name: mutT

Synonym: HI0910

Alternate gene names: 16272847

Gene position: 964502-964912 (Clockwise)

Preceding gene: 16272846

Following gene: 16272848

Centisome position: 52.7

GC content: 38.2

Gene sequence:

>411_bases
ATGGATAAAAAAATTATACAAGTTGCTGCGGGGATTATTCGTAATGAATTTGGTCAGATCTATTTAACGCAGCGTTTAGA
AGGACAGGATTTTGCCCAATCTTTAGAATTTCCCGGTGGAAAAGTAGATGCGGGAGAAACCCCAGAACAGGCTTTAAAAC
GTGAACTGGAAGAGGAAATAGGCATTGTTGCGTTAAATGCAGAACTTTATGAACGTTTTCAATTTGAATATCCAACAAAA
ATCATTTCTTTTTTCTTTTATCTGGTAAATGAATGGATTGGTGAGCCTTTTGGGCGAGAGGGGCAAGAAGGTTTTTGGGT
TGAGCAGCACGCATTGGATGCAGGACAGTTTCCCCCCGCGAATGCAAAATTAATTCATCGATTACTAAATGAAACTCATA
ATTTCATATAA

Upstream 100 bases:

>100_bases
AAGCATTGTCACGGCAGTCGTGTGGCACGCCAGTAATGAACAATCAAAGTGCGGTGATTTTTCACCGCACCTTTTTCATA
CCTCTACATTGGATAGAAAA

Downstream 100 bases:

>100_bases
AATAAATGTGGTTTAAAGTTATATTAAAAGATTTAGTATGATTTATCACATATAACTTTTTAATATACTCGCCAAAATAT
TTGTATTTTTTGCATTATTG

Product: mutator protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEIGIVALNAELYERFQFEYPTK
IISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPANAKLIHRLLNETHNFI

Sequences:

>Translated_136_residues
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEIGIVALNAELYERFQFEYPTK
IISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPANAKLIHRLLNETHNFI
>Mature_136_residues
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEIGIVALNAELYERFQFEYPTK
IISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPANAKLIHRLLNETHNFI

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1786288, Length=125, Percent_Identity=48.8, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1788056, Length=121, Percent_Identity=38.0165289256198, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTT_HAEIN (P44932)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_439070.1
- ProteinModelPortal:   P44932
- SMR:   P44932
- GeneID:   949912
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0910
- NMPDR:   fig|71421.1.peg.876
- TIGR:   HI_0910
- HOGENOM:   HBG741910
- OMA:   EWIGEPF
- ProtClustDB:   CLSK870400
- BioCyc:   HINF71421:HI_0910-MONOMER
- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR01401
- PRINTS:   PR00502
- TIGRFAMs:   TIGR00586

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.-

Molecular weight: Translated: 15648; Mature: 15648

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEI
CCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GIVALNAELYERFQFEYPTKIISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPA
CEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCC
NAKLIHRLLNETHNFI
CHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEI
CCHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GIVALNAELYERFQFEYPTKIISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPA
CEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCC
NAKLIHRLLNETHNFI
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800