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The map label for this gene is hsrA

Identifier: 16272792

GI number: 16272792

Start: 898107

End: 899498

Strand: Direct

Name: hsrA

Synonym: HI0852

Alternate gene names: 16272792

Gene position: 898107-899498 (Clockwise)

Preceding gene: 16272791

Following gene: 16272793

Centisome position: 49.07

GC content: 39.22

Gene sequence:

>1392_bases
ATGACTACTGAATCCAATGCCTATCGCGGTTTAGCTTGGGTAGCAGCAATGGCACTTTTTATGCAAAGCCTCGATGCGAC
CATTCTAAATACAGCTTTACCCGCGATATCTTCCGATTTACATAAACCCGCCTTTGAAATGCAAATGGCGATTATTGCTT
ATTCTTTAGCTGTTGCATTATTTATTCCTCTTACCGCTTGGGCTGCGGCAAAATTTGGGACATTAACCGTTTTTCGTAGT
GCAGTTTTCACGTTTATTTTAGGTTCAGTTGCTTGTGCCGCGGCCTCTAATTTAGAGAGCCTTATTTTAGCCCGAGTGAT
TCAGGGGATAGGCGGTGCCTTTATGATGCCGGTGGCGCGTTTAGCTATTATTCAAGCTGTCCCCAAACAACAATTAGTGA
ATGCTTGGAATTTAATGGCAACTGCAGGTTTGATTGGGCCAATTCTAGGGCCTATTTTAGGTGGATGGTTAGTCATTCAC
GCCAGTTGGCACTGGATTTTTTTAATTAATATTCCAATTGGTGCGCTAGGAATTTTGGCATCGGGCAGCGTGATGAACAA
TATCAAGGGCAAGGCAGAAAAATTAGATTGGACAGGTTTTTTACTCTTTGCATTGGGGTTAGTTGGTATTACGCTTGGTT
TGGATTTACTCGGCGAAAGTCAGCATAATTCAAGTGTAACTTATAGCATATTAGTTGTTGGTATTCTGTTACTCGTAACT
TATTGTGGCTATGCTAAAAACAATGAAAATGCCATTTTACCTTTATCCCTTTTCCGAACTCGTACATTCAGATTAGGTAT
TATTGCCAATATTTTTATCCGATTATCTGCATCTGGTGTGCCCTTTTTATTGCCTTTGATGTTCCAATTATCTTTCGGTT
ACAGTGCTGAAATGTCTGGCTGGCTATTAGCACCGATTGCGTTAATTTCTGTGATGTTGAAAATATTAATTGGACGAATT
TTAAATCGTTGGGGTTATAAAACCACGTTAATTTCATCCGCACTTTTGATGGCAGGTTCTGTGATTTCAATGGCTTGGTT
AGATAAACAAAGCTCTCTAACTTGGATTATTTGTAATCTTATGTGGTATGGGGCTTGTATGTCGATCATTTTTACTTCAA
TTAATACGCTGGCTGTAGGCGATCTTTCAAAACAACAGTCTGGCACAGGCTCTACCGTATTAAGTATTGTACAGCAAGTT
GGGATTGGATTTGGTATTGCTGTGTCATCAATAATCTTAAATCTTTATCGACATTTCTTTAGCGCAAGTGATTGCTTACC
ACAGGCATTCAGCTATACTTTTTTAACTTCATCACTTTTTGTAATCGCCCTTGTTTGGTCGCTTATGAAATTACATAAAC
ATGATGGCGATCATTTACGAAAAATGCCTTAG

Upstream 100 bases:

>100_bases
ATTATCCCCTTGAAATTGACCGCACTTTGTTGGATATTAACCGCATTCCGCAAATTGCCGATTTTATTGAAAATTGGTTG
CACCATTTTCACGGAGCACG

Downstream 100 bases:

>100_bases
ATTAATTTGTTATAATCCATAGAATTTTTTTATTTAAAAAAAGGGAAATTTGCTTATATCTTATTGATATTTCTTGTTGG
TGGAGATAGCTCCATCGTTT

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS
AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH
ASWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI
LNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQV
GIGFGIAVSSIILNLYRHFFSASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP

Sequences:

>Translated_463_residues
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS
AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH
ASWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI
LNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQV
GIGFGIAVSSIILNLYRHFFSASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP
>Mature_462_residues
TTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSA
VFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHA
SWHWIFLINIPIGALGILASGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVTY
CGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRIL
NRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVG
IGFGIAVSSIILNLYRHFFSASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family

Homologues:

Organism=Escherichia coli, GI1790195, Length=459, Percent_Identity=44.2265795206972, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788392, Length=449, Percent_Identity=36.5256124721604, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788710, Length=399, Percent_Identity=31.5789473684211, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1789042, Length=311, Percent_Identity=31.8327974276527, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081983, Length=402, Percent_Identity=25.8706467661692, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788509, Length=167, Percent_Identity=28.1437125748503, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=359, Percent_Identity=26.1838440111421, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=228, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSRA_HAEIN (P44903)

Other databases:

- EMBL:   L42023
- PIR:   B64160
- RefSeq:   NP_439012.1
- ProteinModelPortal:   P44903
- GeneID:   949865
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0852
- NMPDR:   fig|71421.1.peg.820
- TIGR:   HI_0852
- HOGENOM:   HBG679341
- OMA:   MALFMQS
- ProtClustDB:   CLSK870612
- BioCyc:   HINF71421:HI_0852-MONOMER
- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411
- PRINTS:   PR01036
- TIGRFAMs:   TIGR00711

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 50003; Mature: 49872

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50850 MFS; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc450ecc)-; HASH(0xd8f7644)-; HASH(0xcf3ede0)-; HASH(0xd1b30fc)-; HASH(0xd6c2d5c)-; HASH(0xd4ef284)-; HASH(0xd65996c)-; HASH(0x405c4d94)-; HASH(0xb9da938)-; HASH(0xd8c0928)-; HASH(0xd5a55f8)-; HASH(0xd8f5038)-; HASH(0xd8f50c8)-; HASH(0xd85ec20)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEEEEEECCHHHHHHHH
SGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
CCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSG
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
WLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYRHFF
HHHHHHHHHHHHHHHHHEECCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCH
>Mature Secondary Structure 
TTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEEEEEECCHHHHHHHH
SGSVMNNIKGKAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
CCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSG
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
WLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MWYGACMSIIFTSINTLAVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYRHFF
HHHHHHHHHHHHHHHHHEECCCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SASDCLPQAFSYTFLTSSLFVIALVWSLMKLHKHDGDHLRKMP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800