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The map label for this gene is frdA

Identifier: 16272776

GI number: 16272776

Start: 883887

End: 885686

Strand: Reverse

Name: frdA

Synonym: HI0835

Alternate gene names: 16272776

Gene position: 885686-883887 (Counterclockwise)

Preceding gene: 16272778

Following gene: 16272775

Centisome position: 48.39

GC content: 41.94

Gene sequence:

>1800_bases
GTGCAAACAGTTAATGTCGATATTGCGATTGTTGGTGCTGGTGGCGGTGGTTTACGTGCAGCGATTGCCGCAGCAGAAGC
AAATCCTAACTTAAAAATTGCATTAGTTTCTAAAGTATACCCAATGCGTACGCATACTGTAGCAGCAGAAGGTGGCGCAG
CGGCAGTTATCAAAGAAGAAGATTCTTACGATAAACACTTCCAAGATACCGTTGCTGGTGGGGACTGGCTTTGTGAGCAA
GATGTAGTGGAATATTTCGTGCAACATTCCCCTGTAGAAATGACTCAATTAGAACGTTGGGGATGTCCTTGGAGTCGTAA
AGCTGATGGCGATGTAAACGTACGTCGTTTCGGTGGAATGAAAATTGAGCGCACTTGGTTCGCTGCAGATAAAACAGGTT
TCCACTTATTACACACGCTTTTCCAAACTTCTATTCAATATCCACAAATCCAACGTTTTGATGAACACTTCGTATTAGAT
ATTCTTGTTGATGATGGCCATGCTCGTGGTATGGTTGCAATGAATATGATGGAAGGTTCACTTGTTCAAATTAATGCCAA
TGCGGTTGTTATCGCAACTGGTGGTGGTTGTCGTGCATTTAAATTTAATACCAATGGCGGCATTGTAACAGGTGACGGCT
TATCTATGGCATATCGTCACGGTGTACCACTTCGTGATATGGAGTTTGTTCAATATCATCCAACAGGCTTACCTAATACG
GGTATTTTAATGACTGAAGGTTGTCGTGGTGAAGGTGGTATCTTAGTGAATAAAGATGGCTATCGCTATCTTCAAGATTA
CGGTCTAGGTCCTGAAACACCAATTGGCAAACCGCAAAATAAATATATGGAACTTGGCCCTCGTGATAAAGTTTCTCAAG
CATTCTGGCAAGAATGGAAAAAAGGTAATACCTTAAAAACCGCGAAAGGCGTAGATGTGGTGCATTTAGATTTACGTCAT
CTTGGTGAAAAATATTTACATGAGCGTCTGCCATTCATTTGTGAATTAGCAAGTGCTTATGAAGGTGTAAATCCAGTGAA
TGAACCAATCCCTGTTCGTCCAGTTGTTCACTACACCATGGGCGGAATTGAAGTTGATTTTAACAGCGAAACACGTATCA
AAGGTTTATTTGCTGTAGGAGAATGTGCATCTTCAGGTTTACACGGCGCAAATCGTTTAGGATCTAACTCTTTAGCTGAA
CTTGTTGTGTTAGGTCGTGTTGCAGGGGAGTATGCGGCACAACGTGCAGTTGAAGCTCAATCTGTAAATCAAAGTGCGGT
TGATGCTCAAGCAAAAGACGTTGTAGCTCGCCTAGAAGCTCTTCACAAACAAGAAGGTAATGAATCTTGGTCTGAAATCC
GTGATGAAATGGGTACCGTGATGGAAGAAGGTTGTGGTATTTACCGTGACCAAGCAAGTATGCAAAAAGCAGTAGATAAA
ATTGCAGAGTTAAAAGAACGTTACAAACGTATTCGCGTATCAGATAATTCAAGCGTGTTCAATACAGATGTACTTTACAC
CGTTGAGTTGGGTTACATTCTAGATGTTGCGCAATCTATTGCAAATTCAGCGATTGAACGTAAAGAATCTCGTGGTGCTC
ACCAACGCTTAGATTACACAGAACGTGACGATGTCAATTATTTAAAACACACACTTGCTTTCTACAATGAGAATGGTGCG
CCGCGCATTGAATACAGTCCGGTGAAAATTACTAAATCTCAACCTGCAAAACGTGTTTACGGTGCGGAAGCAGAAGCTCA
AGAAGCAGCTGCGAAAGCTAAGGAGCAAGCAAATGGCTAA

Upstream 100 bases:

>100_bases
TAAAANACGTTATTAATTTGTAACGAAAAATGGCACAATGCCCACACAATATTACCCTTTTAGGGGATTTATTTTTACTT
TCTATTGATTGGAGGATATC

Downstream 100 bases:

>100_bases
TTCACCAGTAATGAATGTTGAAGTATTACGCTACAATCCTGAAATCGATCAAGAGCCACATTTAAGCACCTATCAAGTAC
CTTATGATAATCAAACTTCA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PRIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG

Sequences:

>Translated_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PRIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
>Mature_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PRIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily

Homologues:

Organism=Homo sapiens, GI156416003, Length=575, Percent_Identity=37.7391304347826, Blast_Score=364, Evalue=1e-100,
Organism=Escherichia coli, GI1790597, Length=603, Percent_Identity=74.9585406301824, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=542, Percent_Identity=39.4833948339483, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=31.5508021390374, Blast_Score=252, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=38.1308411214953, Blast_Score=344, Evalue=9e-95,
Organism=Caenorhabditis elegans, GI17550100, Length=576, Percent_Identity=35.5902777777778, Blast_Score=340, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI71986328, Length=436, Percent_Identity=27.5229357798165, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322701, Length=556, Percent_Identity=38.6690647482014, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322416, Length=564, Percent_Identity=38.2978723404255, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320788, Length=493, Percent_Identity=25.5578093306288, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137288, Length=598, Percent_Identity=37.9598662207358, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24655642, Length=598, Percent_Identity=37.9598662207358, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24655647, Length=598, Percent_Identity=37.9598662207358, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=34, Blast_Score=335, Evalue=7e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRDA_HAEIN (P44894)

Other databases:

- EMBL:   L42023
- PIR:   H64097
- RefSeq:   NP_438995.1
- ProteinModelPortal:   P44894
- SMR:   P44894
- GeneID:   949849
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0835
- NMPDR:   fig|71421.1.peg.803
- TIGR:   HI_0835
- HOGENOM:   HBG293998
- OMA:   RFDEYFV
- ProtClustDB:   PRK09231
- BioCyc:   HINF71421:HI_0835-MONOMER
- BRENDA:   1.3.99.1
- GO:   GO:0006810
- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006
- Gene3D:   G3DSA:1.20.58.100
- PRINTS:   PR00368
- TIGRFAMs:   TIGR01176
- TIGRFAMs:   TIGR01812

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C; SSF46977 Succ_DH_flav_C

EC number: =1.3.99.1

Molecular weight: Translated: 65934; Mature: 65934

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: ACT_SITE 233-233 ACT_SITE 249-249

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCEEEEEECCCEEEEEECC
DSYDKHFQDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLDILVDDGHARGMVAMNMMEGS
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEEECCCCCCEEEEEECCCC
LVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAQ
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNENGAPRIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
CCCCHHHHHHHHHHCCCCCCCEEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRTHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCEEEEEECCCEEEEEECC
DSYDKHFQDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLDILVDDGHARGMVAMNMMEGS
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEEECCCCCCEEEEEECCCC
LVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAQ
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNENGAPRIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
CCCCHHHHHHHHHHCCCCCCCEEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800