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The map label for this gene is frdB

Identifier: 16272775

GI number: 16272775

Start: 883124

End: 883894

Strand: Reverse

Name: frdB

Synonym: HI0834

Alternate gene names: 16272775

Gene position: 883894-883124 (Counterclockwise)

Preceding gene: 16272776

Following gene: 228918116

Centisome position: 48.3

GC content: 39.3

Gene sequence:

>771_bases
ATGGCTAATTCACCAGTAATGAATGTTGAAGTATTACGCTACAATCCTGAAATCGATCAAGAGCCACATTTAAGCACCTA
TCAAGTACCTTATGATAATCAAACTTCATTGCTTGATGCGTTAGGCTATATTAAGGATAAACTTGAACCATCTCTTTCTT
ATCGTTGGTCTTGCCGTATGGCGATCTGCGGTTCTTGCGGGATGATGGTAAATAACAAACCAAAATTGGCTTGTAAAACT
TTCTTACGTGATTACAGCGGCCATATGCGTATCGAGCCATTAGCAAACTTCCCTATTGAACGCGACTTAGTGGTTGATTT
AAGCCACTTTATCGAAAGTTTAGAGGCAATTAAGCCTTATATTATTGGTAACGAAGCACCAGCATTAGATGGTAAACCAC
ATCCATCGAAAGAATTGCAAGTTAGCCGTACTAAACAAACGCCAGCACAGCTTGAGAAATATCGTCAATTCTCAATGTGT
ATCAACTGTGGTTTATGCTATGCCGCTTGCCCTCAATTTGGTTTAAATCCTGAATTCTTAGGCCCAGCAGCGATTACGAT
GGCTCATCGTTATAATCTTGATAACCGTGACCATGGTAAAGCAAAACGTATGTCATTATTAAATGGTAAAAACGGGGTTT
GGAGTTGTACTTTCGTTGGCTATTGCTCAGAAGTTTGTCCAAAACATGTGGATCCTGCTTCTGCAATTAACCAAGGAAAA
GTGGAAAGTGCCAAAGATTATGTTATCTCTATGCTAAAACCAAAAGGCTAA

Upstream 100 bases:

>100_bases
TACAGTCCGGTGAAAATTACTAAATCTCAACCTGCAAAACGTGTTTACGGTGCGGAAGCAGAAGCTCAAGAAGCAGCTGC
GAAAGCTAAGGAGCAAGCAA

Downstream 100 bases:

>100_bases
GGGGGAAGGAATGTCAGTAACAGTGAGTAAACGTAAAAAATATGTTCGTCCAATGACAGCGACTTGGTGGCAAAAATTGG
ACTTCTACAAAGCTTATATG

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MANSPVMNVEVLRYNPEIDQEPHLSTYQVPYDNQTSLLDALGYIKDKLEPSLSYRWSCRMAICGSCGMMVNNKPKLACKT
FLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNEAPALDGKPHPSKELQVSRTKQTPAQLEKYRQFSMC
INCGLCYAACPQFGLNPEFLGPAAITMAHRYNLDNRDHGKAKRMSLLNGKNGVWSCTFVGYCSEVCPKHVDPASAINQGK
VESAKDYVISMLKPKG

Sequences:

>Translated_256_residues
MANSPVMNVEVLRYNPEIDQEPHLSTYQVPYDNQTSLLDALGYIKDKLEPSLSYRWSCRMAICGSCGMMVNNKPKLACKT
FLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNEAPALDGKPHPSKELQVSRTKQTPAQLEKYRQFSMC
INCGLCYAACPQFGLNPEFLGPAAITMAHRYNLDNRDHGKAKRMSLLNGKNGVWSCTFVGYCSEVCPKHVDPASAINQGK
VESAKDYVISMLKPKG
>Mature_255_residues
ANSPVMNVEVLRYNPEIDQEPHLSTYQVPYDNQTSLLDALGYIKDKLEPSLSYRWSCRMAICGSCGMMVNNKPKLACKTF
LRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPYIIGNEAPALDGKPHPSKELQVSRTKQTPAQLEKYRQFSMCI
NCGLCYAACPQFGLNPEFLGPAAITMAHRYNLDNRDHGKAKRMSLLNGKNGVWSCTFVGYCSEVCPKHVDPASAINQGKV
ESAKDYVISMLKPKG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain

Homologues:

Organism=Homo sapiens, GI115387094, Length=244, Percent_Identity=31.1475409836066, Blast_Score=121, Evalue=7e-28,
Organism=Escherichia coli, GI1790596, Length=255, Percent_Identity=72.5490196078431, Blast_Score=396, Evalue=1e-112,
Organism=Escherichia coli, GI1786943, Length=240, Percent_Identity=37.5, Blast_Score=150, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17533915, Length=239, Percent_Identity=31.3807531380753, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322987, Length=237, Percent_Identity=34.1772151898734, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17137106, Length=240, Percent_Identity=32.5, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=32.0512820512821, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRDB_HAEIN (P44893)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438994.1
- ProteinModelPortal:   P44893
- SMR:   P44893
- GeneID:   949848
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0834
- TIGR:   HI_0834
- HOGENOM:   HBG616382
- OMA:   AACPQYG
- ProtClustDB:   PRK12385
- BioCyc:   HINF71421:HI_0834-MONOMER
- BRENDA:   1.3.99.1
- GO:   GO:0006810
- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489
- Gene3D:   G3DSA:3.10.20.30
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR00384

Pfam domain/function: SSF54292 Ferredoxin; SSF46548 Helical_ferredxn

EC number: =1.3.99.1

Molecular weight: Translated: 28668; Mature: 28537

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSPVMNVEVLRYNPEIDQEPHLSTYQVPYDNQTSLLDALGYIKDKLEPSLSYRWSCRM
CCCCCCEEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNNKPKLACKTFLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPY
EEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNEAPALDGKPHPSKELQVSRTKQTPAQLEKYRQFSMCINCGLCYAACPQFGLNPEFL
EECCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
GPAAITMAHRYNLDNRDHGKAKRMSLLNGKNGVWSCTFVGYCSEVCPKHVDPASAINQGK
CHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCHHHHHCCCC
VESAKDYVISMLKPKG
CHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANSPVMNVEVLRYNPEIDQEPHLSTYQVPYDNQTSLLDALGYIKDKLEPSLSYRWSCRM
CCCCCEEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
AICGSCGMMVNNKPKLACKTFLRDYSGHMRIEPLANFPIERDLVVDLSHFIESLEAIKPY
EEECCCCCEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCE
IIGNEAPALDGKPHPSKELQVSRTKQTPAQLEKYRQFSMCINCGLCYAACPQFGLNPEFL
EECCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
GPAAITMAHRYNLDNRDHGKAKRMSLLNGKNGVWSCTFVGYCSEVCPKHVDPASAINQGK
CHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCHHHHHCCCC
VESAKDYVISMLKPKG
CHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800