Click here to switch to the map view.

The map label for this gene is pepP

Identifier: 16272757

GI number: 16272757

Start: 866859

End: 868151

Strand: Reverse

Name: pepP

Synonym: HI0816

Alternate gene names: 16272757

Gene position: 868151-866859 (Counterclockwise)

Preceding gene: 16272758

Following gene: 16272756

Centisome position: 47.44

GC content: 39.52

Gene sequence:

>1293_bases
ATGGAATTGGCTTATATGGCTAAATTGCCTAAAGAAGAATTTGAGGAACGTCGCACACGAGTATTCGCTCAAATGCAACC
TAATTCGGCATTATTGCTTTTTTCTGAAATCGAAAAACGCCGTAATAATGATTGTACCTATCCTTTCCGTCAAGATAGCT
ATTTTTGGTATTTAACAGGCTTTAATGAACCGAATGCAGCACTGTTATTACTGAAAACAGAACAAGTAGAAAAAGCCATT
ATTTTTCTTCGTCCACGCGATCCGTTACTTGAAACTTGGAATGGTCGCCGATTAGGTGTTGAGCGTGCGCCACAGCAACT
TAATGTAAATGAAGCCTATTCTATTGAAGAATTCGCTACCGTACTGCCAAAAATACTGAAAAATTTGACCGCACTTTACC
ATGTGCCAGAAATTCATACTTGGGGTGATACATTGGTGTCAGAAAGTGCGGTGAATTTTAGCGAGATTTTAGATTGGCGA
CCAATGCTCAGCGAAATGCGCCTTATAAAATCGCCGAATGAAATCCGATTAATGCAACAAGCGGGACAAATTACGGCACT
TGGGCATATTAAAGCGATGCAAACAACACGCCCAAATCGCTTTGAATATGAAATTGAAAGCGATATTTTGCATGAATTTA
ATCGCCATTGCGCAAGATTTCCTTCTTACAATTCCATTGTTGCAGGAGGAAGTAACGCCTGTATTTTGCACTACACAGAA
AATGATCGCCCACTAAATGATGGGGATTTAGTGCTGATTGACGCTGGCTGTGAATTTGCCATGTATGCAGGCGATATCAC
CCGCACTTTTCCTGTAAATGGAAAATTTAGCCAGCCTCAACGTGAAATTTACGAGTTAGTTTTAAAAGCACAAAAACGTG
CGATTGAATTACTTGTACCGGGCAATTCCATTAAGCAAGCCAATGATGAAGTCATTCGAATTAAAACCCAAGGATTAGTG
GATTTAGGTATCTTGAAAGGAGATGTGGATACACTTATTGAACAACAAGCTTATCGCCAATTTTATATGCACGGATTAGG
TCACTGGCTAGGGTTAGATGTGCATGATGTGGGTAGTTATGGCCAAGATAAACAACGGATACTCGAAATCGGTATGGTAA
TTACCGTTGAGCCTGGTATTTATATTTCAGAAGATGCAGATGTGCCAGAGCAATACAAAGGCATTGGCGTGCGCATTGAG
GATAATTTACTGATGACTGAATATGGTAATAAAATCCTAACCGCTGCTGTCCCTAAAGAAATTGCAGACATTGAAAATTT
AATGAATTTTTAA

Upstream 100 bases:

>100_bases
AAATCATTGAATATGTTCGCACCATTGCAATGTTGTTCTATTCTCATTTCAACGAAGGGGAAATTGAGAGCAAACCTGTA
TTACATTAAGGAGATCTAGA

Downstream 100 bases:

>100_bases
TAAAAATGTTTAAATTGTGATCTAGTACACAGTTTTTTATTGCTCAAAATGTTAGCATTGGAGCCAGTTAAAAACCGAAC
CAATCAGTTAAGGAGTCGAT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MELAYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGSNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAVPKEIADIENLMNF

Sequences:

>Translated_430_residues
MELAYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGSNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAVPKEIADIENLMNF
>Mature_430_residues
MELAYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLMQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGSNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAVPKEIADIENLMNF

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family

Homologues:

Organism=Homo sapiens, GI11559925, Length=441, Percent_Identity=36.281179138322, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI149589008, Length=473, Percent_Identity=29.8097251585624, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI260593665, Length=303, Percent_Identity=33.993399339934, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI260593663, Length=467, Percent_Identity=28.2655246252677, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1789275, Length=435, Percent_Identity=53.3333333333333, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI1788728, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790282, Length=445, Percent_Identity=25.3932584269663, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=471, Percent_Identity=31.6348195329087, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71989583, Length=359, Percent_Identity=27.8551532033426, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320922, Length=437, Percent_Identity=32.7231121281465, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321118, Length=426, Percent_Identity=30.2816901408451, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI19920384, Length=415, Percent_Identity=35.6626506024096, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21357079, Length=439, Percent_Identity=35.0797266514806, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPP_HAEIN (P44881)

Other databases:

- EMBL:   L42023
- PIR:   B64096
- RefSeq:   NP_438976.1
- ProteinModelPortal:   P44881
- SMR:   P44881
- MEROPS:   M24.004
- GeneID:   949828
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0816
- NMPDR:   fig|71421.1.peg.784
- TIGR:   HI_0816
- HOGENOM:   HBG545079
- OMA:   VRAMQAC
- ProtClustDB:   CLSK870588
- BioCyc:   HINF71421:HI_0816-MONOMER
- BRENDA:   3.4.11.9
- GO:   GO:0006508
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.9

Molecular weight: Translated: 49262; Mature: 49262

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELAYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTG
CCCHHHHCCCHHHHHHHHHHEEEEECCCCEEEEHHHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNAALLLLKTEQVEKAIIFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFAT
CCCCCCEEEEEEECCCCEEEEEECCCCHHHHCCCCCEECHHCCCCCCCCCCCCCHHHHHH
VLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWRPMLSEMRLIKSPNEIRLMQQ
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGSNACILHYTE
CCCEEEEEEEEEHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECC
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEC
GNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIEDNLLMTEYGNKILTAAVPKE
CCHHHHHHHCCEEEEECCCEEEECCCCCCHHHCCCEEEEECCEEEEECCCEEEEEHHHHH
IADIENLMNF
HHHHHHHHCC
>Mature Secondary Structure
MELAYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTG
CCCHHHHCCCHHHHHHHHHHEEEEECCCCEEEEHHHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNAALLLLKTEQVEKAIIFLRPRDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFAT
CCCCCCEEEEEEECCCCEEEEEECCCCHHHHCCCCCEECHHCCCCCCCCCCCCCHHHHHH
VLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWRPMLSEMRLIKSPNEIRLMQQ
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGSNACILHYTE
CCCEEEEEEEEEHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECC
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLVP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEC
GNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYRQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIEDNLLMTEYGNKILTAAVPKE
CCHHHHHHHCCEEEEECCCEEEECCCCCCHHHCCCEEEEECCEEEEECCCEEEEEHHHHH
IADIENLMNF
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800