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The map label for this gene is argH [H]

Identifier: 16272752

GI number: 16272752

Start: 860834

End: 862207

Strand: Reverse

Name: argH [H]

Synonym: HI0811

Alternate gene names: 16272752

Gene position: 862207-860834 (Counterclockwise)

Preceding gene: 16272753

Following gene: 16272751

Centisome position: 47.11

GC content: 40.76

Gene sequence:

>1374_bases
ATGGCACTTTGGGGTGGGCGTTTTACACAAGCCGCAGATAAGCGTTTTAAAGATTTTAATGATTCATTACGGTTTGATTA
CCGTTTGGCAGAACAGGATATTCAAGGCTCGATTGGTTGGTCCAAAGCCTTGGTGAAAGTCAATGTATTAACTATCGAAG
AACAGCATCAACTTGAGCAAGCACTAAATGAATTACTTGTTGAAGTGCGGTCAAATCCGCAAGCAATTTTACAAGATGAT
GCTGAAGATATTCATAGTTGGGTTGAAAGTAAGCTAATTGATAAAGTAGGCAACCTTGGTAAAAAATTACATACTGGTCG
TAGCCGTAACGATCAAGTGGCAGTCGATATAAAACTGTGGTGCAAACAGCGTGTGATTGAATTACAAGAATCAGTACGTA
ATTTGCAACGACACTTAGTTCAAACCGCAGAAAACACACAACAAGCAGTAATGCCTGGCTATACCCATTTACAACGAGCT
CAACCAATAACTTTTGCCCATTGGTGTATGGCATATGTGGAAATGTTCGACCGCGACTATTCACGTTTAACAGATGCGTA
TAATCGTATGAATACTTGTCCACTTGGTAGTGGTGCGCTGGCTGGTACGGCTTATGCTGTAGATCGTGATTCACTTGCGC
ACGATCTTAGTTTTGCTTTCGCAACTAGAAATAGCTTAGATAGCGTCTCTGATCGCGATCATATCGTAGAATTACTTTCC
ATCGCCTCTCTTAGTATGGCACATCTTTCCCGCTTTGCTGAAGATATGATTATCTTTAACAGCGGAGAAGCAAATTTCGT
GGAACTATCCGATCGTGTGACTTCTGGTTCATCATTAATGCCACAAAAGAAAAATCCCGATGCTTGTGAGTTAATTCGAG
GCAAAACGGGGAGAGTAATTGGTTCATTAACATCTATGTTAATCACCTTAAAAGGCTTGCCACTTGCGTATAATAAAGAT
ATGCAAGAAGACAAAGAGGGTATTTTTGATGCCTTAGATACTTGGCAAAACTGTGTAGATATGGCAACGTTCGTCTTAGA
TGAATTGAAAGTAAATGTTGAACGTACTCGTGAAGCTGCGTTAAAAGGCTATTCAAACGCAACTGAATTAGCGGATTATT
TAGTCTCTAAAGGCGTACCTTTCCGAGATTCCCATCATATCGTAGGCGAAACAGTGGTTTATGCAATCGAGAAAGGCAAA
GGATTAGAAGATCTGACTATCCCTGAATTCCGCCAATTTAGTGAAGTAGTGGGAGATGACGTTTACGAGATTCTTTCTCT
CCAATCTTGCTTAGACAAACGTTGTGCAAAAGGTGGCGTATCGCCATTGCGTGTTGCCGAAGCTATTGCAGAAGCCAAAA
CAAGATTTGCTTAA

Upstream 100 bases:

>100_bases
AGATTTTGTCCATTTTTGTTTTATTATTAATATAGAATATTGCTTTATGAATAAATATGCACAATAATAGAATAATTAAT
TAAAACAAAAAGGAAAAATT

Downstream 100 bases:

>100_bases
TTAATATTATAACTTAGAGATCACATTGGATTTTACAAGCCTCTAAGTGCCACCTATTTATAAGCAAAAACACTTAAATA
AAACGATCAAGACAAAAAGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTIEEQHQLEQALNELLVEVRSNPQAILQDD
AEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLWCKQRVIELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRA
QPITFAHWCMAYVEMFDRDYSRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLS
IASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVIGSLTSMLITLKGLPLAYNKD
MQEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAALKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGK
GLEDLTIPEFRQFSEVVGDDVYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA

Sequences:

>Translated_457_residues
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTIEEQHQLEQALNELLVEVRSNPQAILQDD
AEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLWCKQRVIELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRA
QPITFAHWCMAYVEMFDRDYSRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLS
IASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVIGSLTSMLITLKGLPLAYNKD
MQEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAALKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGK
GLEDLTIPEFRQFSEVVGDDVYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA
>Mature_456_residues
ALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTIEEQHQLEQALNELLVEVRSNPQAILQDDA
EDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLWCKQRVIELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRAQ
PITFAHWCMAYVEMFDRDYSRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLSI
ASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVIGSLTSMLITLKGLPLAYNKDM
QEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAALKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGKG
LEDLTIPEFRQFSEVVGDDVYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=439, Percent_Identity=43.7357630979499, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI68303542, Length=439, Percent_Identity=43.7357630979499, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI68303549, Length=439, Percent_Identity=41.6856492027335, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI68303547, Length=439, Percent_Identity=41.002277904328, Blast_Score=322, Evalue=5e-88,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=73.5229759299781, Blast_Score=699, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=43.7636761487965, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=39.1498881431767, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=39.1498881431767, Blast_Score=333, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51218; Mature: 51086

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTIEEQHQLEQ
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHEEEEEEEEEHHHHHHHH
ALNELLVEVRSNPQAILQDDAEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLW
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHH
CKQRVIELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRAQPITFAHWCMAYVEMFDRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLS
HHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHH
IASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVI
HHHHHHHHHHHHHHHHEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLTSMLITLKGLPLAYNKDMQEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGKGLEDLTIPEFRQFSEVVGDD
HHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
VYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFTQAADKRFKDFNDSLRFDYRLAEQDIQGSIGWSKALVKVNVLTIEEQHQLEQ
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHEEEEEEEEEHHHHHHHH
ALNELLVEVRSNPQAILQDDAEDIHSWVESKLIDKVGNLGKKLHTGRSRNDQVAVDIKLW
HHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHH
CKQRVIELQESVRNLQRHLVQTAENTQQAVMPGYTHLQRAQPITFAHWCMAYVEMFDRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYNRMNTCPLGSGALAGTAYAVDRDSLAHDLSFAFATRNSLDSVSDRDHIVELLS
HHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHH
IASLSMAHLSRFAEDMIIFNSGEANFVELSDRVTSGSSLMPQKKNPDACELIRGKTGRVI
HHHHHHHHHHHHHHHHEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLTSMLITLKGLPLAYNKDMQEDKEGIFDALDTWQNCVDMATFVLDELKVNVERTREAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGYSNATELADYLVSKGVPFRDSHHIVGETVVYAIEKGKGLEDLTIPEFRQFSEVVGDD
HHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
VYEILSLQSCLDKRCAKGGVSPLRVAEAIAEAKTRFA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA