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The map label for this gene is dxr [H]

Identifier: 16272748

GI number: 16272748

Start: 856007

End: 857200

Strand: Reverse

Name: dxr [H]

Synonym: HI0807

Alternate gene names: 16272748

Gene position: 857200-856007 (Counterclockwise)

Preceding gene: 16272749

Following gene: 16272746

Centisome position: 46.84

GC content: 39.28

Gene sequence:

>1194_bases
ATGCAAAAACAAAACATTGTCATTCTTGGTTCAACGGGATCAATCGGTAAGAGTACCCTTTCTGTTATCGAAAATAACCC
TCAGAAATATCATGCATTTGCACTCGTAGGCGGAAAAAATGTAGAAGCAATGTTTGAACAATGTATCAAATTCCGACCGC
ACTTTGCGGCTCTTGATGATGTAAATGCGGCTAAAATTTTACGTGAAAAATTAATTGCGCATCATATTCCAACGGAAGTA
TTAGCAGGACGACGAGCTATTTGCGAACTCGCAGCACACCCAGATGCCGATCAGATAATGGCGTCGATTGTTGGTGCAGC
AGGATTGTTACCGACTCTTTCAGCGGTTAAAGCAGGTAAACGGGTATTACTGGCAAATAAAGAATCACTGGTAACCTGCG
GACAGCTTTTTATTGATGCCGTAAAAAACTATGGCTCGAAGCTTTTACCAGTAGATAGTGAACATAATGCTATCTTTCAA
TCATTACCGCCAGAAGCACAAGAAAAAATCGGTTTTTGCCCACTTTCTGAATTAGGTGTAAGTAAAATTATACTCACTGG
TTCTGGCGGACCATTCCGTTACACGCCACTTGAACAATTCACCAACATAACACCAGAACAAGCGGTTGCACACCCTAATT
GGTCTATGGGTAAAAAAATTTCTGTCGATTCAGCTACAATGATGAATAAGGGCTTGGAATACATTGAGGCTCGCTGGCTT
TTCAATGCAAGTGCGGAAGAAATGGAAGTTATTATTCATCCACAATCAATTATTCATTCTATGGTACGGTATGTTGACGG
CTCAGTCATTACTCAAATGGGAAATCCAGATATGCGTACACCAATTGCAGAAACTATGGCATATCCTCACCGCACTTTTG
CTGGAGTAGAACCACTCGATTTCTTTAAAATCAAAGAACTGACATTTATTGAACCTGATTTTAATCGCTATCCAAATTTA
AAACTGGCTATTGATGCCTTTGCTGCGGGTCAATATGCGACAACAGCAATGAATGCAGCTAATGAAATTGCCGTACAAGC
ATTTTTAGATCGTCAAATTGGCTTTATGGATATTGCAAAAATTAATTCGAAAACAATTGAGAGAATTTCGCCTTATACCA
TTCAAAATATTGATGATGTACTCGAAATTGATGCACAAGCAAGAGAGATTGCGAAAACACTACTTAGAGAATAG

Upstream 100 bases:

>100_bases
ATGCGAAAGGCAGACAGTTTTGTCTGCCTTTATTTTATTAGGTATGCAAATTTAGACGTACCAATGAAAATGTAATCAAC
AAAAGTGCGGTAAAGATTCT

Downstream 100 bases:

>100_bases
ACCTAGAATAACTAGGTCTAGTTTATTCGATTTAATGGAATACAAATTCCAAAATGCACATATAGGCTGCAATACAAAAT
AAAATAATCGCCAATAATTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQKQNIVILGSTGSIGKSTLSVIENNPQKYHAFALVGGKNVEAMFEQCIKFRPHFAALDDVNAAKILREKLIAHHIPTEV
LAGRRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGKRVLLANKESLVTCGQLFIDAVKNYGSKLLPVDSEHNAIFQ
SLPPEAQEKIGFCPLSELGVSKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWL
FNASAEEMEVIIHPQSIIHSMVRYVDGSVITQMGNPDMRTPIAETMAYPHRTFAGVEPLDFFKIKELTFIEPDFNRYPNL
KLAIDAFAAGQYATTAMNAANEIAVQAFLDRQIGFMDIAKINSKTIERISPYTIQNIDDVLEIDAQAREIAKTLLRE

Sequences:

>Translated_397_residues
MQKQNIVILGSTGSIGKSTLSVIENNPQKYHAFALVGGKNVEAMFEQCIKFRPHFAALDDVNAAKILREKLIAHHIPTEV
LAGRRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGKRVLLANKESLVTCGQLFIDAVKNYGSKLLPVDSEHNAIFQ
SLPPEAQEKIGFCPLSELGVSKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWL
FNASAEEMEVIIHPQSIIHSMVRYVDGSVITQMGNPDMRTPIAETMAYPHRTFAGVEPLDFFKIKELTFIEPDFNRYPNL
KLAIDAFAAGQYATTAMNAANEIAVQAFLDRQIGFMDIAKINSKTIERISPYTIQNIDDVLEIDAQAREIAKTLLRE
>Mature_397_residues
MQKQNIVILGSTGSIGKSTLSVIENNPQKYHAFALVGGKNVEAMFEQCIKFRPHFAALDDVNAAKILREKLIAHHIPTEV
LAGRRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGKRVLLANKESLVTCGQLFIDAVKNYGSKLLPVDSEHNAIFQ
SLPPEAQEKIGFCPLSELGVSKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWL
FNASAEEMEVIIHPQSIIHSMVRYVDGSVITQMGNPDMRTPIAETMAYPHRTFAGVEPLDFFKIKELTFIEPDFNRYPNL
KLAIDAFAAGQYATTAMNAANEIAVQAFLDRQIGFMDIAKINSKTIERISPYTIQNIDDVLEIDAQAREIAKTLLRE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=62.7249357326478, Blast_Score=503, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43668; Mature: 43668

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQNIVILGSTGSIGKSTLSVIENNPQKYHAFALVGGKNVEAMFEQCIKFRPHFAALDD
CCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCC
VNAAKILREKLIAHHIPTEVLAGRRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGK
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RVLLANKESLVTCGQLFIDAVKNYGSKLLPVDSEHNAIFQSLPPEAQEKIGFCPLSELGV
EEEEECCHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHCCCCHHHHHCCCCCHHHCCC
SKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWL
EEEEEECCCCCEECCCHHHHHCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHE
FNASAEEMEVIIHPQSIIHSMVRYVDGSVITQMGNPDMRTPIAETMAYPHRTFAGVEPLD
ECCCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHCCCCHHHCCCCCCH
FFKIKELTFIEPDFNRYPNLKLAIDAFAAGQYATTAMNAANEIAVQAFLDRQIGFMDIAK
HEEECCEEEECCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
INSKTIERISPYTIQNIDDVLEIDAQAREIAKTLLRE
CCHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKQNIVILGSTGSIGKSTLSVIENNPQKYHAFALVGGKNVEAMFEQCIKFRPHFAALDD
CCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCC
VNAAKILREKLIAHHIPTEVLAGRRAICELAAHPDADQIMASIVGAAGLLPTLSAVKAGK
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RVLLANKESLVTCGQLFIDAVKNYGSKLLPVDSEHNAIFQSLPPEAQEKIGFCPLSELGV
EEEEECCHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHCCCCHHHHHCCCCCHHHCCC
SKIILTGSGGPFRYTPLEQFTNITPEQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWL
EEEEEECCCCCEECCCHHHHHCCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHE
FNASAEEMEVIIHPQSIIHSMVRYVDGSVITQMGNPDMRTPIAETMAYPHRTFAGVEPLD
ECCCCCCEEEEECCHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHCCCCHHHCCCCCCH
FFKIKELTFIEPDFNRYPNLKLAIDAFAAGQYATTAMNAANEIAVQAFLDRQIGFMDIAK
HEEECCEEEECCCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
INSKTIERISPYTIQNIDDVLEIDAQAREIAKTLLRE
CCHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA