Click here to switch to the map view.

The map label for this gene is ilvA

Identifier: 16272680

GI number: 16272680

Start: 794559

End: 796100

Strand: Direct

Name: ilvA

Synonym: HI0738.1

Alternate gene names: 16272680

Gene position: 794559-796100 (Clockwise)

Preceding gene: 16272679

Following gene: 30995397

Centisome position: 43.42

GC content: 40.92

Gene sequence:

>1542_bases
ATGAAAAATCTACTCACCAATCCTCAACCCTCTCAATCAGATTATATCAATGCCATTGTTAAACTTGGTTCGCGCGTATA
TGAAGCTGCACAAGTGACCCCTTTACAAAAAATGGGAAAACTTTCTGAACGACTGCACAATAATATCTGGATTAAACGAG
AAGACCGTCAGCCAGTAAATAGCTTTAAACTACGCGGCGCTTACGCAATGATTTCTAGCCTTTCAGCAGAACAAAAAGCA
GCTGGCGTAATAGCAGCCTCTGCGGGTAACCATGCGCAAGGCGTGGCATTATCGGCGAAACAATTAGGCTTAAAAGCATT
AATTGTTATGCCACAAAACACCCCAAGCATTAAAGTGGATGCAGTGCGTGGTTTTGGTGGTGAGGTGTTGTTGCACGGTG
CTAATTTCGATGAAGCCAAAGCAAAAGCCATCGAGCTTTCAAAAGAAAAAAACATGACATTTATTCCACCATTCGATCAT
CCATTAGTGATCGCAGGACAAGGCACGTTAGCGATGGAAATGCTACAACAAGTGGCGGATTTGGATTATGTGTTTGTACA
AGTTGGTGGTGGTGGCTTAGCTGCGGGTGTGGCAATTTTGCTTAAGCAATTTATGCCGGAAATTAAAATCATCGGTGTAG
AATCAAAGGATTCTGCGTGCTTAAAAGCGGCTCTCGATAAAGGCGAACCAACAGATTTAACCCATATTGGATTATTTGCC
GATGGCGTTGCTGTAAAACGCATTGGCGACGAAACATTCCGTCTATGTCAGCAATATCTTGATGATATGGTATTGGTCGA
TAGTGACGAAGTATGCGCAGCAATGAAAGATTTGTTTGAGAACGTTCGTGCTGTTGCAGAACCATCAGGTGCATTAGGTT
TGGCTGGTTTGAAAAAATATGTAAAACAAAACCATATTGAAGGCAAAAATATGGCGGCAATTTTGTCTGGCGCGAACTTG
AATTTCCACACATTACGTTATGTATCTGAACGTTGTGAAATTGGTGAAAATCGAGAGGCTTTATTAGCCGTGACCATGCC
TGAACAACCAGGTAGTTTCTTAAAATTTGCTTATGTATTAGGTAACCGAGCTGTAACCGAATTCAGTTATCGTTATGCAG
ATGATAAACGCGCTTGCGTGTTTGTTGGGGTAAGAACGACAAATGAGCAAGAAAAAGCAGATATTATTGCAGACCTCACG
AAAAATGGTTTTGATGTTGAGGATATGTCTGATGATGATATTGCGAAAACGCATGTTCGCTATTTAATGGGTGGTCGTGC
AGCCAATGATAACGAACGCTTATATACCTTCGAATTCCCAGAGCAAAAAGGTGCCTTATTAAAATTCTTGGAAACCTTGC
AAAATCGTTGGAATATTTCATTATTCCACTATCGTGCCCATGGTGCGGACTATGGAAATATCCTTGCAGGTTTCCAAATT
GAACAACGCGAACAAGCAGAATTTGAACAGGGACTTGCCCAACTCAATTATGTTTTTGAAGATGTAACAAAAAGCAAATC
TTATCGTTATTTCTTACGTTAA

Upstream 100 bases:

>100_bases
GATAAAACATTATTAAAATAATTTAACGGTTCCCCTCTTTCATAAGAGGGGGATAAAACAAAGGAAAAACTAACCGCACT
TTATCATCAAAACAAACACT

Downstream 100 bases:

>100_bases
TCCTATAAAAAAGGCGTGATATTTTTCACGCCTTTGTCTTATTCAAACTCTAATTCCACCGCACTTTCGCCGAGTAAATT
CACCAATTCCGTCAGAATTT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKNLLTNPQPSQSDYINAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVNSFKLRGAYAMISSLSAEQKA
AGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVDAVRGFGGEVLLHGANFDEAKAKAIELSKEKNMTFIPPFDH
PLVIAGQGTLAMEMLQQVADLDYVFVQVGGGGLAAGVAILLKQFMPEIKIIGVESKDSACLKAALDKGEPTDLTHIGLFA
DGVAVKRIGDETFRLCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKYVKQNHIEGKNMAAILSGANL
NFHTLRYVSERCEIGENREALLAVTMPEQPGSFLKFAYVLGNRAVTEFSYRYADDKRACVFVGVRTTNEQEKADIIADLT
KNGFDVEDMSDDDIAKTHVRYLMGGRAANDNERLYTFEFPEQKGALLKFLETLQNRWNISLFHYRAHGADYGNILAGFQI
EQREQAEFEQGLAQLNYVFEDVTKSKSYRYFLR

Sequences:

>Translated_513_residues
MKNLLTNPQPSQSDYINAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVNSFKLRGAYAMISSLSAEQKA
AGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVDAVRGFGGEVLLHGANFDEAKAKAIELSKEKNMTFIPPFDH
PLVIAGQGTLAMEMLQQVADLDYVFVQVGGGGLAAGVAILLKQFMPEIKIIGVESKDSACLKAALDKGEPTDLTHIGLFA
DGVAVKRIGDETFRLCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKYVKQNHIEGKNMAAILSGANL
NFHTLRYVSERCEIGENREALLAVTMPEQPGSFLKFAYVLGNRAVTEFSYRYADDKRACVFVGVRTTNEQEKADIIADLT
KNGFDVEDMSDDDIAKTHVRYLMGGRAANDNERLYTFEFPEQKGALLKFLETLQNRWNISLFHYRAHGADYGNILAGFQI
EQREQAEFEQGLAQLNYVFEDVTKSKSYRYFLR
>Mature_513_residues
MKNLLTNPQPSQSDYINAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVNSFKLRGAYAMISSLSAEQKA
AGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVDAVRGFGGEVLLHGANFDEAKAKAIELSKEKNMTFIPPFDH
PLVIAGQGTLAMEMLQQVADLDYVFVQVGGGGLAAGVAILLKQFMPEIKIIGVESKDSACLKAALDKGEPTDLTHIGLFA
DGVAVKRIGDETFRLCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKYVKQNHIEGKNMAAILSGANL
NFHTLRYVSERCEIGENREALLAVTMPEQPGSFLKFAYVLGNRAVTEFSYRYADDKRACVFVGVRTTNEQEKADIIADLT
KNGFDVEDMSDDDIAKTHVRYLMGGRAANDNERLYTFEFPEQKGALLKFLETLQNRWNISLFHYRAHGADYGNILAGFQI
EQREQAEFEQGLAQLNYVFEDVTKSKSYRYFLR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family

Homologues:

Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=31.25, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI19923959, Length=271, Percent_Identity=30.9963099630996, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI33469958, Length=310, Percent_Identity=26.1290322580645, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790207, Length=505, Percent_Identity=66.9306930693069, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1789505, Length=316, Percent_Identity=38.9240506329114, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789235, Length=314, Percent_Identity=27.0700636942675, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=332, Percent_Identity=33.1325301204819, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17537387, Length=365, Percent_Identity=32.6027397260274, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508781, Length=285, Percent_Identity=31.2280701754386, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320930, Length=516, Percent_Identity=48.4496124031008, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322631, Length=320, Percent_Identity=36.875, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=285, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355833, Length=349, Percent_Identity=30.6590257879656, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24645328, Length=244, Percent_Identity=30.7377049180328, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THD1_HAEIN (P46493)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438898.1
- ProteinModelPortal:   P46493
- SMR:   P46493
- GeneID:   950764
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0738.1
- NMPDR:   fig|71421.1.peg.707
- TIGR:   HI_0738.1
- HOGENOM:   HBG714501
- OMA:   YIAPFDD
- ProtClustDB:   PRK09224
- BioCyc:   HINF71421:HI_0738.1-MONOMER
- BRENDA:   4.3.1.19
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721
- TIGRFAMs:   TIGR01124

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.3.1.19

Molecular weight: Translated: 56663; Mature: 56663

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLLTNPQPSQSDYINAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCH
SFKLRGAYAMISSLSAEQKAAGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVD
HHHHHHHHHHHHHHCHHHHHCEEEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCCEEEE
AVRGFGGEVLLHGANFDEAKAKAIELSKEKNMTFIPPFDHPLVIAGQGTLAMEMLQQVAD
EEECCCCEEEEECCCCCHHHHHHHEEHHCCCEEEECCCCCCEEEECCCHHHHHHHHHHHC
LDYVFVQVGGGGLAAGVAILLKQFMPEIKIIGVESKDSACLKAALDKGEPTDLTHIGLFA
CEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEE
DGVAVKRIGDETFRLCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKY
CCCHHHHCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
VKQNHIEGKNMAAILSGANLNFHTLRYVSERCEIGENREALLAVTMPEQPGSFLKFAYVL
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
GNRAVTEFSYRYADDKRACVFVGVRTTNEQEKADIIADLTKNGFDVEDMSDDDIAKTHVR
CCCHHHHEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
YLMGGRAANDNERLYTFEFPEQKGALLKFLETLQNRWNISLFHYRAHGADYGNILAGFQI
HHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCEE
EQREQAEFEQGLAQLNYVFEDVTKSKSYRYFLR
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MKNLLTNPQPSQSDYINAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCH
SFKLRGAYAMISSLSAEQKAAGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVD
HHHHHHHHHHHHHHCHHHHHCEEEEECCCCCCCCEEEEHHHCCCEEEEEECCCCCCEEEE
AVRGFGGEVLLHGANFDEAKAKAIELSKEKNMTFIPPFDHPLVIAGQGTLAMEMLQQVAD
EEECCCCEEEEECCCCCHHHHHHHEEHHCCCEEEECCCCCCEEEECCCHHHHHHHHHHHC
LDYVFVQVGGGGLAAGVAILLKQFMPEIKIIGVESKDSACLKAALDKGEPTDLTHIGLFA
CEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEE
DGVAVKRIGDETFRLCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKY
CCCHHHHCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
VKQNHIEGKNMAAILSGANLNFHTLRYVSERCEIGENREALLAVTMPEQPGSFLKFAYVL
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
GNRAVTEFSYRYADDKRACVFVGVRTTNEQEKADIIADLTKNGFDVEDMSDDDIAKTHVR
CCCHHHHEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
YLMGGRAANDNERLYTFEFPEQKGALLKFLETLQNRWNISLFHYRAHGADYGNILAGFQI
HHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCEE
EQREQAEFEQGLAQLNYVFEDVTKSKSYRYFLR
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800