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The map label for this gene is ilvD [H]

Identifier: 16272679

GI number: 16272679

Start: 792641

End: 794479

Strand: Direct

Name: ilvD [H]

Synonym: HI0738

Alternate gene names: 16272679

Gene position: 792641-794479 (Clockwise)

Preceding gene: 16272678

Following gene: 16272680

Centisome position: 43.31

GC content: 43.45

Gene sequence:

>1839_bases
ATGCCCAAACTACGTTCAGCGACCAGCACACAAGGTCGTAATATGGCAGGCGCACGTGCCTTATGGCGTGCAACAGGAAT
GAAAGAAAATGACTTTGGTAAACCGATTATTGCGGTGGTGAACTCTTTCACGCAATTCGTACCAGGGCATGTGCATTTAA
AAGATATGGGACAGCTTGTTGCCGCAGAAATAGAAAAAGCGGGCGGCGTAGCAAAAGAATTTAACACCATTGCGGTGGAT
GATGGTATCGCAATGGGTCACGGTGGAATGCTTTATTCTTTACCAAGCCGTGATTTAATCGCTGATAGCGTGGAATATAT
GGTCAATGCACACTGTGCTGATGCGATGGTGTGTATTTCTAACTGTGACAAAATCACCCCGGGAATGTTAATGGCGGCAA
TGCGCTTAAACATTCCGACAATTTTTGTTTCAGGCGGCCCAATGGAAGCGGGCAAAACAAAACTTTCTGATCAATTAATC
CGCTTAGATTTGGTTGATGCGATGATTGAGGCAGCCGATCCGAATGTATCAGATGAACGTATTGATGCCATCGAACGCAG
TGCGTGTCCAACTTGTGGTTCATGTTCTGGTATGTTTACCGCTAACTCAATGAACTGCTTAACTGAAGCCTTAGGTTTAT
CTTTACCTGGTAATGGTTCTATGTTAGCCACTCACGCAGACCGTAAAGAATTATTCTTAAAAGCAGGTCGTCAAATTGTC
GAGCTTTGCAAACGCTATTATGAACAAGATGATGCAAGCGTATTGCCTCGTTCAATCGGTACTTTTGATGCCTTTGAAAA
TGCAATGAGCCTCGATATCGCAATGGGTGGTTCAAGTAACACTGTTTTACACTTATTAGCGGCAGCACAAGAAGCAGGCG
TGGATTTTAAAATGGAAGATATTGACCGTTTATCGCGCAAAGTGCCTTGTTTAAGCAAAATTGCACCAAACACCAATAAA
TATCATATGGAAGACGTACACCGTGCAGGCGGTATTATGGGATTGTTGGGTGAATTAGATCGTGCTGGATTAATTCATAA
AAATACACACACCGTGCTTGGAATGAGCATGGGAGAGCAACTAGACCAATACGATATTATTCGCAATCAAGATGAAGAAT
TACATAAATTCTTCCGTGCAGGCCCTGCAGGTATCCGCACAACTCAAGCATTCTCACAAGATTGCCGCTGGGATACCGTT
GATAATGATCGTGTAAACGGTTGTATTCGCAATAAAGAAAATGCGATTTCACAAGAAGGTGGCTTAGCCGTATTATTCGG
TAATCTCGCTGAAGACGGATGTATCGTTAAAACCGCTGGTGTAGATGAATCTATTTGGAAATTCACTGGCACGGCAATCG
TATTTGAAAGCCAAGAAGATGCGGTTGCAGGCATTTTAGGTGGCAAAGTCAAAGAAGGTCATGTTGTTGTTATCCGTTAC
GAAGGGCCTAAAGGCGGACCAGGTATGCAAGAAATGTTATACCCAACCAGTTACTTAAAATCGATGGGCTTGGGCAAAAA
ATGCGCTTTATTAACGGATGGTCGCTTCTCTGGCGGTACATCAGGCTTGTCTATTGGACATGTTTCACCAGAAGCTGCTT
CTGGCGGTGCAATCGGCTTAGTACGCAATGGCGATATTATCAACATTGATATTCCAAACCGTGCAATTAACTTAGAAATC
AGTAATGAAGAACTCGCAACACGCAGAGCCGAACAAGATCAAAAAGGTTGGCAGCCAGCTAACCGTGAACGTGAAGTATC
TTTCGCTTTAAAAGTATTCGGTCACTTTGCGACCTCAGCGGACAAAGGTGCGGTACGCGATAAAACATTATTAAAATAA

Upstream 100 bases:

>100_bases
AGCTGCCGGATGTTTTAATGGTTAATTAAGAATATTTTATCAATTAACGAAGAAATTAATCATACAAACGAACCCTAAAT
TTTACTCGGAGAGATTATTT

Downstream 100 bases:

>100_bases
TTTAACGGTTCCCCTCTTTCATAAGAGGGGGATAAAACAAAGGAAAAACTAACCGCACTTTATCATCAAAACAAACACTA
TGAAAAATCTACTCACCAAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAAEIEKAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKTKLSDQLI
RLDLVDAMIEAADPNVSDERIDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLKAGRQIV
ELCKRYYEQDDASVLPRSIGTFDAFENAMSLDIAMGGSSNTVLHLLAAAQEAGVDFKMEDIDRLSRKVPCLSKIAPNTNK
YHMEDVHRAGGIMGLLGELDRAGLIHKNTHTVLGMSMGEQLDQYDIIRNQDEELHKFFRAGPAGIRTTQAFSQDCRWDTV
DNDRVNGCIRNKENAISQEGGLAVLFGNLAEDGCIVKTAGVDESIWKFTGTAIVFESQEDAVAGILGGKVKEGHVVVIRY
EGPKGGPGMQEMLYPTSYLKSMGLGKKCALLTDGRFSGGTSGLSIGHVSPEAASGGAIGLVRNGDIINIDIPNRAINLEI
SNEELATRRAEQDQKGWQPANREREVSFALKVFGHFATSADKGAVRDKTLLK

Sequences:

>Translated_612_residues
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAAEIEKAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKTKLSDQLI
RLDLVDAMIEAADPNVSDERIDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLKAGRQIV
ELCKRYYEQDDASVLPRSIGTFDAFENAMSLDIAMGGSSNTVLHLLAAAQEAGVDFKMEDIDRLSRKVPCLSKIAPNTNK
YHMEDVHRAGGIMGLLGELDRAGLIHKNTHTVLGMSMGEQLDQYDIIRNQDEELHKFFRAGPAGIRTTQAFSQDCRWDTV
DNDRVNGCIRNKENAISQEGGLAVLFGNLAEDGCIVKTAGVDESIWKFTGTAIVFESQEDAVAGILGGKVKEGHVVVIRY
EGPKGGPGMQEMLYPTSYLKSMGLGKKCALLTDGRFSGGTSGLSIGHVSPEAASGGAIGLVRNGDIINIDIPNRAINLEI
SNEELATRRAEQDQKGWQPANREREVSFALKVFGHFATSADKGAVRDKTLLK
>Mature_611_residues
PKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAAEIEKAGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKTKLSDQLIR
LDLVDAMIEAADPNVSDERIDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLKAGRQIVE
LCKRYYEQDDASVLPRSIGTFDAFENAMSLDIAMGGSSNTVLHLLAAAQEAGVDFKMEDIDRLSRKVPCLSKIAPNTNKY
HMEDVHRAGGIMGLLGELDRAGLIHKNTHTVLGMSMGEQLDQYDIIRNQDEELHKFFRAGPAGIRTTQAFSQDCRWDTVD
NDRVNGCIRNKENAISQEGGLAVLFGNLAEDGCIVKTAGVDESIWKFTGTAIVFESQEDAVAGILGGKVKEGHVVVIRYE
GPKGGPGMQEMLYPTSYLKSMGLGKKCALLTDGRFSGGTSGLSIGHVSPEAASGGAIGLVRNGDIINIDIPNRAINLEIS
NEELATRRAEQDQKGWQPANREREVSFALKVFGHFATSADKGAVRDKTLLK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=77.6872964169381, Blast_Score=1013, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=560, Percent_Identity=30.5357142857143, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1788157, Length=565, Percent_Identity=28.8495575221239, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=31.7399617590822, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=605, Percent_Identity=36.8595041322314, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65824; Mature: 65693

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AAEIEKAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKTKLSDQLIRLDLVDAMIEAADPNVSDER
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLKAGRQIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELCKRYYEQDDASVLPRSIGTFDAFENAMSLDIAMGGSSNTVLHLLAAAQEAGVDFKMED
HHHHHHHCCCCHHHCCHHCCCHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
IDRLSRKVPCLSKIAPNTNKYHMEDVHRAGGIMGLLGELDRAGLIHKNTHTVLGMSMGEQ
HHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCEEEECHHHHH
LDQYDIIRNQDEELHKFFRAGPAGIRTTQAFSQDCRWDTVDNDRVNGCIRNKENAISQEG
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCC
GLAVLFGNLAEDGCIVKTAGVDESIWKFTGTAIVFESQEDAVAGILGGKVKEGHVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHEECCEEEEECCCCHHHHHHCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSMGLGKKCALLTDGRFSGGTSGLSIGHVSPEAASGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VRNGDIINIDIPNRAINLEISNEELATRRAEQDQKGWQPANREREVSFALKVFGHFATSA
EECCCEEEEECCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
DKGAVRDKTLLK
CCCCCCCHHCCC
>Mature Secondary Structure 
PKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AAEIEKAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPTIFVSGGPMEAGKTKLSDQLIRLDLVDAMIEAADPNVSDER
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLKAGRQIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELCKRYYEQDDASVLPRSIGTFDAFENAMSLDIAMGGSSNTVLHLLAAAQEAGVDFKMED
HHHHHHHCCCCHHHCCHHCCCHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
IDRLSRKVPCLSKIAPNTNKYHMEDVHRAGGIMGLLGELDRAGLIHKNTHTVLGMSMGEQ
HHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEECCCCEEEECHHHHH
LDQYDIIRNQDEELHKFFRAGPAGIRTTQAFSQDCRWDTVDNDRVNGCIRNKENAISQEG
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCC
GLAVLFGNLAEDGCIVKTAGVDESIWKFTGTAIVFESQEDAVAGILGGKVKEGHVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHEECCEEEEECCCCHHHHHHCCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSMGLGKKCALLTDGRFSGGTSGLSIGHVSPEAASGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VRNGDIINIDIPNRAINLEISNEELATRRAEQDQKGWQPANREREVSFALKVFGHFATSA
EECCCEEEEECCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
DKGAVRDKTLLK
CCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA