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The map label for this gene is plsC

Identifier: 16272675

GI number: 16272675

Start: 788247

End: 788969

Strand: Reverse

Name: plsC

Synonym: HI0734

Alternate gene names: 16272675

Gene position: 788969-788247 (Counterclockwise)

Preceding gene: 16272677

Following gene: 16272674

Centisome position: 43.11

GC content: 37.9

Gene sequence:

>723_bases
ATGTTAAAACTACTTCGAATTTTCCTCGTATTAATCTGCTGTATTCTAATTTGTGTACTGGGTACGATTTATTCTTTTAT
CCGCTTTAAAAATCCAAGCAACGTAGGCATTGTTGCACGTTGGTTTGGACGCTTATATCCACTTTTTGGCTTAAAGGTAG
AACATCGTATTCCTCAAGATCAGAAGCAAATTAGCCGCGCCATTTATATCGGTAATCATCAAAATAATTATGATATGGTA
ACAATCTCTTATATGGTGCAACCTCGTACAGTAAGCGTGGGTAAAAAAAGCTTAATTTGGATACCCTTCTTCGGAATTTT
ATATTGGGTAACGGGTAATATTTTCTTGGATAGAGAAAACCGCACAAAAGCACATAATACGATGTCACAGCTTGCACGAC
GAATTAATGAAGATAATTTATCAATTTGGATGTTCCCAGAAGGCACTCGCAATCGCGGTCGCGGTTTATTACCCTTTAAA
ACGGGTGCATTCCATGCAGCGATTTCAGCAGGTGTACCAATTATTCCAGTGGTGTGTTCAAGCACGCATAACAAAATTAA
TTTAAATCGTTGGGATAATGGCAAAGTGATTTGCGAAATAATGGATCCAATCGATGTTTCAGGCTATACCAAAGACAATG
TTCGCGATCTTGCGGCTTATTGTCATGATCTAATGGAAAAACGCATTGCCGAACTTGATGAAGAGATAGCAAAAGGAAAC
TAA

Upstream 100 bases:

>100_bases
ATAGCTATGTTTCATAAAAATTCCACGATTTTTGTTTAGATTAGCACATATTGAGATCGAATTTGTTATACTTCAAGGAA
ATTTTATATAGGACATCCTT

Downstream 100 bases:

>100_bases
AATGCCACGCCTTTCCCGCCGTCAATTATTAAAAACAGCTGCGATTTCTACCGCACTTTCCACAGTGCCAGCACCATTGT
TAGCGGCAAGCCGTGAAAAA

Product: 1-acyl-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MLKLLRIFLVLICCILICVLGTIYSFIRFKNPSNVGIVARWFGRLYPLFGLKVEHRIPQDQKQISRAIYIGNHQNNYDMV
TISYMVQPRTVSVGKKSLIWIPFFGILYWVTGNIFLDRENRTKAHNTMSQLARRINEDNLSIWMFPEGTRNRGRGLLPFK
TGAFHAAISAGVPIIPVVCSSTHNKINLNRWDNGKVICEIMDPIDVSGYTKDNVRDLAAYCHDLMEKRIAELDEEIAKGN

Sequences:

>Translated_240_residues
MLKLLRIFLVLICCILICVLGTIYSFIRFKNPSNVGIVARWFGRLYPLFGLKVEHRIPQDQKQISRAIYIGNHQNNYDMV
TISYMVQPRTVSVGKKSLIWIPFFGILYWVTGNIFLDRENRTKAHNTMSQLARRINEDNLSIWMFPEGTRNRGRGLLPFK
TGAFHAAISAGVPIIPVVCSSTHNKINLNRWDNGKVICEIMDPIDVSGYTKDNVRDLAAYCHDLMEKRIAELDEEIAKGN
>Mature_240_residues
MLKLLRIFLVLICCILICVLGTIYSFIRFKNPSNVGIVARWFGRLYPLFGLKVEHRIPQDQKQISRAIYIGNHQNNYDMV
TISYMVQPRTVSVGKKSLIWIPFFGILYWVTGNIFLDRENRTKAHNTMSQLARRINEDNLSIWMFPEGTRNRGRGLLPFK
TGAFHAAISAGVPIIPVVCSSTHNKINLNRWDNGKVICEIMDPIDVSGYTKDNVRDLAAYCHDLMEKRIAELDEEIAKGN

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Homologues:

Organism=Homo sapiens, GI6041665, Length=225, Percent_Identity=31.1111111111111, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI5453718, Length=210, Percent_Identity=31.9047619047619, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI15100175, Length=210, Percent_Identity=31.9047619047619, Blast_Score=124, Evalue=7e-29,
Organism=Escherichia coli, GI1789395, Length=238, Percent_Identity=62.1848739495798, Blast_Score=316, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17564032, Length=177, Percent_Identity=35.5932203389831, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17568319, Length=234, Percent_Identity=30.3418803418803, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320151, Length=236, Percent_Identity=30.9322033898305, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281364648, Length=234, Percent_Identity=30.3418803418803, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24582856, Length=234, Percent_Identity=30.3418803418803, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24582854, Length=234, Percent_Identity=30.3418803418803, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24641614, Length=185, Percent_Identity=33.5135135135135, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24641612, Length=185, Percent_Identity=33.5135135135135, Blast_Score=114, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PLSC_HAEIN (P44848)

Other databases:

- EMBL:   L42023
- PIR:   D64089
- RefSeq:   NP_438893.1
- ProteinModelPortal:   P44848
- GeneID:   950749
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0734
- TIGR:   HI_0734
- HOGENOM:   HBG736534
- OMA:   NEINREA
- ProtClustDB:   CLSK869967
- BioCyc:   HINF71421:HI_0734-MONOMER
- BRENDA:   2.3.1.51
- InterPro:   IPR002123
- InterPro:   IPR004552
- SMART:   SM00563
- TIGRFAMs:   TIGR00530

Pfam domain/function: PF01553 Acyltransferase

EC number: =2.3.1.51

Molecular weight: Translated: 27503; Mature: 27503

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLLRIFLVLICCILICVLGTIYSFIRFKNPSNVGIVARWFGRLYPLFGLKVEHRIPQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEECCCCCHH
QKQISRAIYIGNHQNNYDMVTISYMVQPRTVSVGKKSLIWIPFFGILYWVTGNIFLDREN
HHHHHHEEEECCCCCCCEEEEEEEEECCEEECCCCCEEEEHHHHHHHHHHHCCEEEECCC
RTKAHNTMSQLARRINEDNLSIWMFPEGTRNRGRGLLPFKTGAFHAAISAGVPIIPVVCS
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
STHNKINLNRWDNGKVICEIMDPIDVSGYTKDNVRDLAAYCHDLMEKRIAELDEEIAKGN
CCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKLLRIFLVLICCILICVLGTIYSFIRFKNPSNVGIVARWFGRLYPLFGLKVEHRIPQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEECCCCCHH
QKQISRAIYIGNHQNNYDMVTISYMVQPRTVSVGKKSLIWIPFFGILYWVTGNIFLDREN
HHHHHHEEEECCCCCCCEEEEEEEEECCEEECCCCCEEEEHHHHHHHHHHHCCEEEECCC
RTKAHNTMSQLARRINEDNLSIWMFPEGTRNRGRGLLPFKTGAFHAAISAGVPIIPVVCS
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
STHNKINLNRWDNGKVICEIMDPIDVSGYTKDNVRDLAAYCHDLMEKRIAELDEEIAKGN
CCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800