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The map label for this gene is clpX

Identifier: 16272655

GI number: 16272655

Start: 763649

End: 764884

Strand: Direct

Name: clpX

Synonym: HI0715

Alternate gene names: 16272655

Gene position: 763649-764884 (Clockwise)

Preceding gene: 161350016

Following gene: 16272656

Centisome position: 41.73

GC content: 36.08

Gene sequence:

>1236_bases
ATGACAGACAAAGATAAAGATTTGCACTGCTCTTTTTGCGGAAAGGAAAAAGGCGAAGTAGATAGATTAATTGCTGGCAC
AGACGGTTATATTTGTAATGAATGTATTGAACTTTGTCACTCAATGCTTGAAGAAAGTCATGATAAAAATTTAGAGGAAA
GTGCGGTAGAAAATGAAGAAAAATTACCAACACCTCACGAAATTCGCGCTCATCTAGATGATTATGTTATCGGTCAAGAT
TATGCGAAAAAAGTGCTTTCTGTGGCAGTTTATAATCATTATAAACGCTTGCGAACTAACTATGAAAGCAATGATGTAGA
GCTTGGTAAAAGTAATATTTTACTTATAGGCCCTACAGGTAGCGGAAAAACGTTACTTGCGCAAACATTAGCTCGTCGTT
TAAATGTACCCTTTGCGATGGCGGATGCAACCACATTAACGGAAGCTGGTTATGTGGGGGAAGATGTGGAGAATGTGTTA
CAGAAACTTTTGCAAAATTGTGAATACGATACTGAAAAAGCAGAGAAAGGCATTATTTATATTGATGAAATTGATAAAAT
TAGCCGTAAATCGGAAGGCGCATCAATTACTCGAGATGTTTCAGGAGAGGGGGTGCAACAGGCTTTATTAAAACTTATTG
AAGGTACAATCGCTTCCATTCCACCTCAAGGCGGTCGTAAACATCCACAACAAGAAATGGTAAAATTGGATACGTCTAAA
ATTCTCTTTATTTGCGGCGGTGCATTTGCAGGATTAGATAAAATTATTGATAAACGCACTCAAACCAGTACGAGTATTGG
TTTTAATGCCAAAGTTGAAAAAGATGAAAAACAACAATCTCTTTCTGAATTATTCCGTCAAGTTGAACCTGATGATTTAA
TGAAATTTGGTTTAATTCCAGAATTTATTGGACGCTTGCCAATGATTGCTCCATTAAGTGAATTAGACGAAGATGCGCTG
ATACAAATTCTCACAAAACCAAAAAACGCATTAATTAAACAATATCAAGCCTTATTTGGATTGGAAAAAGTAGAATTGGA
TTTCACACCAGAAGCATTAAAAGCAATGGCGAAAAAAGCACTTGAAAGAAAAACGGGTGCGCGTGGCTTACGTTCTATCG
TAGAAGCAGTGTTGTTAGATACAATGTATGATCTACCGTCTCTTGAGAATTTACAAAAAGTTATCGTTGATGAATCGACA
ATTGTAGATAATCTTGCACCAAAATTAGAATATTAG

Upstream 100 bases:

>100_bases
TATTGAGAAAGATACTGACCGTGATAATTTTATGTCAGCTGAAGAAGCACAAGCGTATGGTTTGGTGGATGAAGTCTTGG
TTAAACGTTAAGGGTATATA

Downstream 100 bases:

>100_bases
ATTTAATCGCAAAAGTGCGGTTGTTTTCACCAGATTTTCTATGTTGATGCTATTTTCAATAGGCAAGGCGAAAAGAAAAT
GCTACAATCGCAGGTTCTTA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTDKDKDLHCSFCGKEKGEVDRLIAGTDGYICNECIELCHSMLEESHDKNLEESAVENEEKLPTPHEIRAHLDDYVIGQD
YAKKVLSVAVYNHYKRLRTNYESNDVELGKSNILLIGPTGSGKTLLAQTLARRLNVPFAMADATTLTEAGYVGEDVENVL
QKLLQNCEYDTEKAEKGIIYIDEIDKISRKSEGASITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPQQEMVKLDTSK
ILFICGGAFAGLDKIIDKRTQTSTSIGFNAKVEKDEKQQSLSELFRQVEPDDLMKFGLIPEFIGRLPMIAPLSELDEDAL
IQILTKPKNALIKQYQALFGLEKVELDFTPEALKAMAKKALERKTGARGLRSIVEAVLLDTMYDLPSLENLQKVIVDEST
IVDNLAPKLEY

Sequences:

>Translated_411_residues
MTDKDKDLHCSFCGKEKGEVDRLIAGTDGYICNECIELCHSMLEESHDKNLEESAVENEEKLPTPHEIRAHLDDYVIGQD
YAKKVLSVAVYNHYKRLRTNYESNDVELGKSNILLIGPTGSGKTLLAQTLARRLNVPFAMADATTLTEAGYVGEDVENVL
QKLLQNCEYDTEKAEKGIIYIDEIDKISRKSEGASITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPQQEMVKLDTSK
ILFICGGAFAGLDKIIDKRTQTSTSIGFNAKVEKDEKQQSLSELFRQVEPDDLMKFGLIPEFIGRLPMIAPLSELDEDAL
IQILTKPKNALIKQYQALFGLEKVELDFTPEALKAMAKKALERKTGARGLRSIVEAVLLDTMYDLPSLENLQKVIVDEST
IVDNLAPKLEY
>Mature_410_residues
TDKDKDLHCSFCGKEKGEVDRLIAGTDGYICNECIELCHSMLEESHDKNLEESAVENEEKLPTPHEIRAHLDDYVIGQDY
AKKVLSVAVYNHYKRLRTNYESNDVELGKSNILLIGPTGSGKTLLAQTLARRLNVPFAMADATTLTEAGYVGEDVENVLQ
KLLQNCEYDTEKAEKGIIYIDEIDKISRKSEGASITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPQQEMVKLDTSKI
LFICGGAFAGLDKIIDKRTQTSTSIGFNAKVEKDEKQQSLSELFRQVEPDDLMKFGLIPEFIGRLPMIAPLSELDEDALI
QILTKPKNALIKQYQALFGLEKVELDFTPEALKAMAKKALERKTGARGLRSIVEAVLLDTMYDLPSLENLQKVIVDESTI
VDNLAPKLEY

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=304, Percent_Identity=53.6184210526316, Blast_Score=314, Evalue=1e-85,
Organism=Escherichia coli, GI1786642, Length=417, Percent_Identity=69.7841726618705, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1790366, Length=100, Percent_Identity=45, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=293, Percent_Identity=47.098976109215, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71982905, Length=309, Percent_Identity=45.6310679611651, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71988663, Length=391, Percent_Identity=38.1074168797954, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI71988660, Length=260, Percent_Identity=39.6153846153846, Blast_Score=167, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=425, Percent_Identity=43.0588235294118, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24648291, Length=299, Percent_Identity=47.8260869565217, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24648289, Length=299, Percent_Identity=47.8260869565217, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_HAEIN (P44838)

Other databases:

- EMBL:   L42023
- PIR:   E64088
- RefSeq:   NP_438873.1
- ProteinModelPortal:   P44838
- GeneID:   949862
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0715
- TIGR:   HI_0715
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   HINF71421:HI_0715-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45734; Mature: 45603

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKDKDLHCSFCGKEKGEVDRLIAGTDGYICNECIELCHSMLEESHDKNLEESAVENEE
CCCCCCCCEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHH
KLPTPHEIRAHLDDYVIGQDYAKKVLSVAVYNHYKRLRTNYESNDVELGKSNILLIGPTG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEECCC
SGKTLLAQTLARRLNVPFAMADATTLTEAGYVGEDVENVLQKLLQNCEYDTEKAEKGIIY
CCHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
IDEIDKISRKSEGASITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPQQEMVKLDTSK
EECHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC
ILFICGGAFAGLDKIIDKRTQTSTSIGFNAKVEKDEKQQSLSELFRQVEPDDLMKFGLIP
EEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCHH
EFIGRLPMIAPLSELDEDALIQILTKPKNALIKQYQALFGLEKVELDFTPEALKAMAKKA
HHHCCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHH
LERKTGARGLRSIVEAVLLDTMYDLPSLENLQKVIVDESTIVDNLAPKLEY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDKDKDLHCSFCGKEKGEVDRLIAGTDGYICNECIELCHSMLEESHDKNLEESAVENEE
CCCCCCCEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHH
KLPTPHEIRAHLDDYVIGQDYAKKVLSVAVYNHYKRLRTNYESNDVELGKSNILLIGPTG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEECCC
SGKTLLAQTLARRLNVPFAMADATTLTEAGYVGEDVENVLQKLLQNCEYDTEKAEKGIIY
CCHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
IDEIDKISRKSEGASITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPQQEMVKLDTSK
EECHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCC
ILFICGGAFAGLDKIIDKRTQTSTSIGFNAKVEKDEKQQSLSELFRQVEPDDLMKFGLIP
EEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCHH
EFIGRLPMIAPLSELDEDALIQILTKPKNALIKQYQALFGLEKVELDFTPEALKAMAKKA
HHHCCCCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHH
LERKTGARGLRSIVEAVLLDTMYDLPSLENLQKVIVDESTIVDNLAPKLEY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800