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The map label for this gene is glpT

Identifier: 16272628

GI number: 16272628

Start: 730072

End: 731514

Strand: Direct

Name: glpT

Synonym: HI0686

Alternate gene names: 16272628

Gene position: 730072-731514 (Clockwise)

Preceding gene: 16272624

Following gene: 16272629

Centisome position: 39.89

GC content: 41.51

Gene sequence:

>1443_bases
ATGTTTGGACCATTCAAACCCGCTCCGCATATTGCGGAACTTCCAGCGGAGAAAATTGATTCCACGTATAAACGCTTACG
TTGGCAAGTGTTTGCAGGGATCTTCTTCGGTTATGCTGCATATTATTTTGTGCGTGCAAACTTTGACTTAGCACAACCAG
GTTTAATTCAAGCTGGCTTGTACTCAAAAGCGGAACTAGGTGTTATCGGCTCAGCGGCTGGTCTTGCTTACGGTTTATCA
AAATTCGTTATGGCAGGTATGTCTGACCGTTCTAACCCTCGTGTATTCTTACCATTTGGTTTATTGCTCTCTGGTTTATG
TATGACCTTAATGGGTTTATTCCCATGGGCAACTTCAGGCATTGCCATTATGTGGGTAATGATCTTCTTAAATGGTTGGT
TCCAAGGTATGGGTTGGCCTCCATGTGGTCGTACTATGGTGCATTGGTGGTCTAAATCTGAACGCGGTACTATCGTGTCA
ATTTGGAATACGGCGCATAATATCGGTGGTATGGTTCCAGGTGCAATGGTGTTATTAGCTAGTGCAATTTTCTTCAGCAC
TCACGGTATTGAAGCGCAGGCGAAAGATGTTTGGCAACAATCATTATACTTCCCTGGTATTGCTGCGATGATCTTTGCAA
TTCCTGTGTACTTCGTGATGCGTGATACTCCACAATCTTGTGGTTTACCATCAATCGAAAAATGGCGTAATGACTACCCA
GATGACTATAACGAAAAAACTTACGAAAACGATTTAACTGCAAAAGAAATCTTCGTAACTTATGTATTAAAAAACAAATT
GTTATGGTATATCGCGATTGCTAACGTGTTCGTCTATTTAATCCGCTACGGTGTATTAAAATGGTCTCCAGTTTACTTGA
GTGAAGTGAAACACTTCAATATCAAAGGTACTGCATGGGCATACACAATCTATGAATTAGCAGCGGTTCCAGGTACATTA
TTATGTGGTTGGGTATCAGATAAAGTGTTTAAAGGTAAACGTGGTTTAACTGGTTTCATCTTTATGATCTTAACCACTGC
AGCGGTTGTTGCGTACTGGATGAACCCAGCTACACCAGAAGCAGAGCTTGCAAACTACTCAGCTTGGTATGAAAACCCAT
ATCAATTAACTGATTTCGTATTAATGACCTTAATCGGTTTCTTAATCTACGGTCCTGTAATGTTAATTGGCTTACACGCT
CTTGAGCTTGCACCGAAAAAAGCAGCAGGTACGGCAGCAGGTTTCACTGGTTTATTCGGTTACTTAGGTGGTACTGTATC
AGCTTCAGCAGTTATTGGTTGGGCTGCTCAACATTACGGATGGGACGGTGGTTTCTACGTAATGATCGGCGGTGGCGTAT
TAGCAGTGTTATTACTCTTAATCGTAATGGTTGAAGAAGGAAAACACAAAGCGAAATTAGGCGATACTTACGGTACTAAA
TAA

Upstream 100 bases:

>100_bases
ACTTTCTTATTTTTTATTTTCTTTTATGATTCGCAAATCCCTTACTGTTTCAAAAGGGTAAATTTAGATGACACATAATT
AAAAAGTTGGAGAAAAAATT

Downstream 100 bases:

>100_bases
TTAGCTTAAAAAAGGCGGTGGGCAAATTGCTTAGTCGCCTTTTTTGTAACTATCATAAGAATAATAAAAAGATAAGTATC
ATTTTTGGGAAAAGTAAAAA

Product: glycerol-3-phosphatase transporter

Products: Proton [Cytoplasm]; glycerol-3-phosphate [Cytoplasm] [C]

Alternate protein names: G-3-P transporter; G-3-P permease

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGLYSKAELGVIGSAAGLAYGLS
KFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSGIAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVS
IWNTAHNIGGMVPGAMVLLASAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYP
DDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFNIKGTAWAYTIYELAAVPGTL
LCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPEAELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHA
LELAPKKAAGTAAGFTGLFGYLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK

Sequences:

>Translated_480_residues
MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGLYSKAELGVIGSAAGLAYGLS
KFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSGIAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVS
IWNTAHNIGGMVPGAMVLLASAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYP
DDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFNIKGTAWAYTIYELAAVPGTL
LCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPEAELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHA
LELAPKKAAGTAAGFTGLFGYLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK
>Mature_480_residues
MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGLYSKAELGVIGSAAGLAYGLS
KFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSGIAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVS
IWNTAHNIGGMVPGAMVLLASAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYP
DDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFNIKGTAWAYTIYELAAVPGTL
LCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPEAELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHA
LELAPKKAAGTAAGFTGLFGYLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK

Specific function: Responsible for glycerol-3-phosphate uptake

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family

Homologues:

Organism=Homo sapiens, GI256219543, Length=478, Percent_Identity=26.1506276150628, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI256219598, Length=455, Percent_Identity=27.032967032967, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503847, Length=455, Percent_Identity=27.032967032967, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI256219483, Length=455, Percent_Identity=27.032967032967, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI256219564, Length=378, Percent_Identity=25.1322751322751, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI223717983, Length=431, Percent_Identity=24.5939675174014, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI38093649, Length=431, Percent_Identity=24.5939675174014, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788573, Length=479, Percent_Identity=60.9603340292276, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87082310, Length=464, Percent_Identity=35.5603448275862, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI2367259, Length=466, Percent_Identity=31.9742489270386, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI133930953, Length=480, Percent_Identity=21.4583333333333, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901856, Length=470, Percent_Identity=23.4042553191489, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901854, Length=470, Percent_Identity=23.4042553191489, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17542316, Length=472, Percent_Identity=21.8220338983051, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564204, Length=426, Percent_Identity=23.2394366197183, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17564202, Length=415, Percent_Identity=23.1325301204819, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656866, Length=499, Percent_Identity=21.4428857715431, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550478, Length=499, Percent_Identity=21.4428857715431, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656861, Length=499, Percent_Identity=21.4428857715431, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPT_HAEIN (P96335)

Other databases:

- EMBL:   L42023
- EMBL:   AF001172
- EMBL:   AF132901
- RefSeq:   NP_438846.1
- ProteinModelPortal:   P96335
- SMR:   P96335
- GeneID:   949719
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0686
- TIGR:   HI_0686
- HOGENOM:   HBG559184
- OMA:   PPDEKIK
- ProtClustDB:   CLSK870484
- BioCyc:   HINF71421:HI_0686-MONOMER
- InterPro:   IPR005267
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159
- TIGRFAMs:   TIGR00881
- TIGRFAMs:   TIGR00712

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 53046; Mature: 53046

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00942 GLPT; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd1145b0)-; HASH(0xd44f548)-; HASH(0xcb1938c)-; HASH(0xd323e40)-; HASH(0xd546b44)-; HASH(0xcef1c64)-; HASH(0xd0accfc)-; HASH(0xb6c8334)-; HASH(0xd45caf8)-; HASH(0xd2e34c8)-; HASH(0xc2a8004)-; HASH(0xd250c70)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGL
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECCC
YSKAELGVIGSAAGLAYGLSKFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCC
IAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVSIWNTAHNIGGMVPGAMVLLA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHCCCCHHHHHHHH
SAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYP
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
DDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
IKGTAWAYTIYELAAVPGTLLCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPE
CCCCHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
AELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFG
HHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
YLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK
HHCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHCCCCCCCH
>Mature Secondary Structure
MFGPFKPAPHIAELPAEKIDSTYKRLRWQVFAGIFFGYAAYYFVRANFDLAQPGLIQAGL
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECCC
YSKAELGVIGSAAGLAYGLSKFVMAGMSDRSNPRVFLPFGLLLSGLCMTLMGLFPWATSG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCC
IAIMWVMIFLNGWFQGMGWPPCGRTMVHWWSKSERGTIVSIWNTAHNIGGMVPGAMVLLA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHCCCCHHHHHHHH
SAIFFSTHGIEAQAKDVWQQSLYFPGIAAMIFAIPVYFVMRDTPQSCGLPSIEKWRNDYP
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
DDYNEKTYENDLTAKEIFVTYVLKNKLLWYIAIANVFVYLIRYGVLKWSPVYLSEVKHFN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
IKGTAWAYTIYELAAVPGTLLCGWVSDKVFKGKRGLTGFIFMILTTAAVVAYWMNPATPE
CCCCHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
AELANYSAWYENPYQLTDFVLMTLIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFG
HHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
YLGGTVSASAVIGWAAQHYGWDGGFYVMIGGGVLAVLLLLIVMVEEGKHKAKLGDTYGTK
HHCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glycerol-3-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glycerol-3-phosphate [Periplasm] = Proton [Cytoplasm] + glycerol-3-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 9714837