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The map label for this gene is glpG

Identifier: 16272560

GI number: 16272560

Start: 651782

End: 652360

Strand: Direct

Name: glpG

Synonym: HI0618

Alternate gene names: 16272560

Gene position: 651782-652360 (Clockwise)

Preceding gene: 16272559

Following gene: 16272561

Centisome position: 35.61

GC content: 36.61

Gene sequence:

>579_bases
ATGAAAAACTTTTTAGCTCAACAAGGAAAAATCACGCTAATTCTCACCGCACTTTGTGTGCTTATTTATCTTGCTCAACA
GCTGGGTTTTGAAGACGATATTATGTATTTGATGCATTACCCCGCTTACGAAGAGCAAGATAGTGAAGTGTGGCGTTATA
TCTCACATACATTGGTACATTTATCTAATTTGCATATTTTGTTTAATCTGTCTTGGTTTTTTATTTTCGGTGGAATGATT
GAGCGCACTTTTGGCTCGGTTAAATTATTGATGTTGTATGTTGTAGCATCTGCCATAACAGGATATGTGCAAAATTATGT
GTCTGGCCCCGCTTTCTTTGGGCTTTCTGGTGTTGTATATGCGGTTCTAGGTTATGTATTTATACGTGATAAATTGAATC
ATCATTTATTTGATCTGCCAGAAGGTTTTTTTACAATGTTATTGGTGGGGATCGCATTAGGTTTTATTAGCCCCTTATTT
GGTGTTGAAATGGGAAATGCTGCACATATTTCAGGCTTGATTGTCGGCTTGATTTGGGGATTTATTGATAGCAAATTGCG
CAAAAATTCGCTAGAGTAA

Upstream 100 bases:

>100_bases
ACGCAGAAGAATTGACGATTACCCACCCCATTACAGGGGAAACAATGACTTTTAATGCGAAGTCCGATTTTTAAATTTAC
GCATAAGCACGAGATCACGA

Downstream 100 bases:

>100_bases
GTCCGTTTAATTTGGATAAAGGATTCGCTATGAAACAATCGTTACGCCATCAAAAAATTATTAAACTGGTGGAACAATCT
GGCTATTTAAGCACGGAAGA

Product: glp protein

Products: NA

Alternate protein names: Intramembrane serine protease

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGGMI
ERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLF
GVEMGNAAHISGLIVGLIWGFIDSKLRKNSLE

Sequences:

>Translated_192_residues
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGGMI
ERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLF
GVEMGNAAHISGLIVGLIWGFIDSKLRKNSLE
>Mature_192_residues
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGGMI
ERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLF
GVEMGNAAHISGLIVGLIWGFIDSKLRKNSLE

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family

Homologues:

Organism=Escherichia coli, GI48994938, Length=186, Percent_Identity=39.247311827957, Blast_Score=138, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPG_HAEIN (P44783)

Other databases:

- EMBL:   L42023
- PIR:   I64081
- RefSeq:   NP_438776.1
- PDB:   2NR9
- PDBsum:   2NR9
- ProteinModelPortal:   P44783
- SMR:   P44783
- MEROPS:   S54.024
- GeneID:   950685
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0618
- NMPDR:   fig|71421.1.peg.587
- TIGR:   HI_0618
- HOGENOM:   HBG495087
- OMA:   WRYISHT
- ProtClustDB:   CLSK808430
- BioCyc:   HINF71421:HI_0618-MONOMER
- BRENDA:   3.4.21.105
- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764
- PANTHER:   PTHR22936

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid

EC number: =3.4.21.105

Molecular weight: Translated: 21658; Mature: 21658

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 169-169

Signals:

None

Transmembrane regions:

HASH(0xd2c14bc)-; HASH(0xcf56c4c)-; HASH(0xcfe6fac)-; HASH(0xcffb0a8)-; HASH(0xd0fa7a0)-; HASH(0xb1973bc)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVH
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIWG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FIDSKLRKNSLE
HHHHHHHHCCCH
>Mature Secondary Structure
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVH
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIWG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FIDSKLRKNSLE
HHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800