Click here to switch to the map view.

The map label for this gene is fucK

Identifier: 16272555

GI number: 16272555

Start: 643894

End: 645306

Strand: Reverse

Name: fucK

Synonym: HI0613

Alternate gene names: 16272555

Gene position: 645306-643894 (Counterclockwise)

Preceding gene: 30995389

Following gene: 16272554

Centisome position: 35.26

GC content: 38.5

Gene sequence:

>1413_bases
ATGGCTATCGCATTGATTTTTGACTGTGGTGCAACAAATTTACGCACCATTGCGATAAATGAAAAAGGACAAATTCTTGC
CTCTCATCACCTTGCTAATAATACAAAACAAGGAATCGAATCATCTGATTATCATATTTGGGATATTGAAGAAATCTGGC
AAAAATTAACCTCTTGTGCAACTCAAACCCTCAATCAATTAATGCAACAAGGTATTGATTTAAAAGATATTGTAGGAATA
TCTGTTACCACTTTCGGCGTGGATGGCGCACCTTTTGATGAAAATGATCAACAACTTTATCCGATTATTTCATGGAAATG
CCCACGGACCATACCAGTAATGGAAAATCTATCTAATCAATTAGATATCAAATCTCTTTATCAACGTAACGGCATTGGTC
AATACAGTTTTAATACTTTATTTAAATTACATTGGTTAAAAACACACAAGCCAGATGTTTTCCAAAAAATGGCTAAATTC
GTTTTTATTTCGTCAATGCTCACTCAACGCTTAACTGGTCAATTCACTACAGATCACACAATGGCGGGAACATCAATGAT
GACAAACCTTACTAGCGGTAATTGGGATCCATCGATTTTAGCATCGCTAGGTTTAAGTAATAACCATTTCCCTCCTATGC
GTTATGCAGGTGAAAAAGTTGGAAAATTACGTACACCGTTAGCCCAGAAATGGGGATTAAATCCCGTACCTGTCATTTCT
TGTGGACATGATACTCAATTTGCTGTGTTTGGGTCTGGTGCAGGGCTGAATCAGCCTGTGTTAAGTTCTGGCACCTGGGA
AATCTTAATGGCTAGAACCCAGCACGCAGAACCTAGATTTGAGTTTGTTTCTCAAGGCTTAACCACTGAATTTGATGCAC
AATCCAATTGCTTTAATCCAGCGGTACAATGGGTGGGTTCTGGCGTCATAGAATGGTTAGGTAAATTATTATTTTCCGAT
GTTTATGGCAGCGATCACTATTACACCACAATGATCAAAGAGGGAGAAAAAGCTTTTAATGCGGGAAAAAGAGCGGTCAA
TTTTGAAGGTATTTTTAGCCAACTAGGACAAGGTAATATCAGTGGACTTTCCATGTTTGCTACTCGTGGAGAAATTTATG
TCAGCGCATTACAACATATGGCAAATAAACTCAAAAACGGTTTATCCGTGCTACATCAAGTCAGTCAGTTCCAAGCTAAA
AGCTTAATTTGTGTTGGGGGTGGTTCAAAAAATGTATTGTGGAATCAAATCCGTGCAAACACCTTAAATTTACCGATTGA
TGTTGTGGACATTTCTGAAAGTACTGTACTTGGTGCCGCAATGTTTACCTTTGCAGGCGTAGGCATTTACGAAAATGTAA
ACGCGGCACAGCAAGCGATGCAACCAACAAGAAAACGAATTTACCCAAACTAG

Upstream 100 bases:

>100_bases
CCAAAACTTTGGTCCGCTTTATAAATAACCCCTAATTTGTTTTTATAAAAAAGTGCGGTCAAAAACATAATGATTTTTGA
CTGCGCTGAGGAGAGTTTTT

Downstream 100 bases:

>100_bases
AAGGAACAACAAAATGCTAAAAGGTATTCACCCAGCTCTTTCTCCTGAATTACTAAAAACCCTCGCCGAAATGGGGCATG
GCGATGAGATAGTTCTAGCT

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCATQTLNQLMQQGIDLKDIVGI
SVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQLDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKF
VFISSMLTQRLTGQFTTDHTMAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVIS
CGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNPAVQWVGSGVIEWLGKLLFSD
VYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNISGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAK
SLICVGGGSKNVLWNQIRANTLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN

Sequences:

>Translated_470_residues
MAIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCATQTLNQLMQQGIDLKDIVGI
SVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQLDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKF
VFISSMLTQRLTGQFTTDHTMAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVIS
CGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNPAVQWVGSGVIEWLGKLLFSD
VYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNISGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAK
SLICVGGGSKNVLWNQIRANTLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN
>Mature_469_residues
AIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCATQTLNQLMQQGIDLKDIVGIS
VTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQLDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKFV
FISSMLTQRLTGQFTTDHTMAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVISC
GHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNPAVQWVGSGVIEWLGKLLFSDV
YGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNISGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAKS
LICVGGGSKNVLWNQIRANTLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI42794763, Length=455, Percent_Identity=24.3956043956044, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI189409120, Length=454, Percent_Identity=24.2290748898678, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4504007, Length=454, Percent_Identity=24.2290748898678, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI41393575, Length=450, Percent_Identity=22.4444444444444, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789168, Length=469, Percent_Identity=40.9381663113006, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1790338, Length=449, Percent_Identity=24.9443207126949, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787789, Length=487, Percent_Identity=22.9979466119097, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789987, Length=437, Percent_Identity=22.883295194508, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790005, Length=493, Percent_Identity=21.501014198783, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790361, Length=478, Percent_Identity=21.5481171548117, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=454, Percent_Identity=22.6872246696035, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24655555, Length=443, Percent_Identity=23.0248306997743, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655560, Length=443, Percent_Identity=23.0248306997743, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655570, Length=443, Percent_Identity=23.0248306997743, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655574, Length=443, Percent_Identity=23.0248306997743, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655565, Length=443, Percent_Identity=23.0248306997743, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922058, Length=237, Percent_Identity=24.0506329113924, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUCK_HAEIN (P44399)

Other databases:

- EMBL:   L42023
- PIR:   E64081
- RefSeq:   NP_438771.1
- ProteinModelPortal:   P44399
- GeneID:   950556
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0613
- NMPDR:   fig|71421.1.peg.582
- TIGR:   HI_0613
- HOGENOM:   HBG296691
- OMA:   VQWVSSG
- ProtClustDB:   PRK10331
- BioCyc:   HINF71421:HI_0613-MONOMER
- BRENDA:   2.7.1.51
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450
- PANTHER:   PTHR10196
- TIGRFAMs:   TIGR02628

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.51

Molecular weight: Translated: 51950; Mature: 51819

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCA
CEEEEEEECCCCCEEEEEECCCCCEEEHHHHHCCHHHCCCCCCCEEECHHHHHHHHHHHH
TQTLNQLMQQGIDLKDIVGISVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQ
HHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCHH
LDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKFVFISSMLTQRLTGQFTTDHT
CHHHHHHHHCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
MAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVIS
HCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEE
CGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNP
CCCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCCHH
AVQWVGSGVIEWLGKLLFSDVYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHCCCCEEEHHHHHHHHCCCCC
SGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAKSLICVGGGSKNVLWNQIRAN
CCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCC
TLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN
EECCCEEEEECCCCHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCA
EEEEEEECCCCCEEEEEECCCCCEEEHHHHHCCHHHCCCCCCCEEECHHHHHHHHHHHH
TQTLNQLMQQGIDLKDIVGISVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQ
HHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCHH
LDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKFVFISSMLTQRLTGQFTTDHT
CHHHHHHHHCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
MAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVIS
HCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEE
CGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNP
CCCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHCCCCHHHHHHHCCCCCCCCCCCCCCHH
AVQWVGSGVIEWLGKLLFSDVYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHCCCCEEEHHHHHHHHCCCCC
SGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAKSLICVGGGSKNVLWNQIRAN
CCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCC
TLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN
EECCCEEEEECCCCHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800