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The map label for this gene is fusA [H]

Identifier: 16272523

GI number: 16272523

Start: 597746

End: 599848

Strand: Reverse

Name: fusA [H]

Synonym: HI0579

Alternate gene names: 16272523

Gene position: 599848-597746 (Counterclockwise)

Preceding gene: 16272524

Following gene: 16272522

Centisome position: 32.78

GC content: 40.61

Gene sequence:

>2103_bases
ATGGCTCGTACAACCCCTATTGAAAGATATCGTAATATCGGTATCAGTGCGCATATTGATGCGGGTAAAACTACTACTAC
TGAGCGTATCTTATTCTATACTGGTGTTAGCCACAAAATCGGTGAAGTGCACGATGGTGCAGCAACGATGGACTGGATGG
AACAAGAACAAGAGCGTGGTATCACCATTACCTCTGCGGCAACAACTGCATTCTGGTCTGGTATGTCACAACAATTCCCA
CAACATCGTATCAATGTTATTGATACTCCGGGACACGTGGACTTTACTGTTGAAGTAGAACGTTCTATGCGTGTTCTTGA
TGGTGCGGTAATGGTTTACTGTGCGGTTGGTGGTGTTCAACCACAATCTGAAACCGTATGGCGTCAAGCTAATAAATATG
AAGTTCCGCGTATTGCGTTTGTAAATAAAATGGACCGTACTGGTGCTAACTTCTTACGTGTTGTTGAACAATTAAAAACT
CGCTTAGGTGCTAATGCTATTCCTCTTCAACTCCCTGTTGGTGCAGAAGAAAACTTCACAGGTGTAGTTGATTTGATCAA
AATGAAAGCGATCAATTGGAATGAAGCAGACCAAGGTATGACTTTCACTTATGAAGAAGTGCCTGCTAATATGCAAGCAG
ACTGTGAAGAATGGCGTCAAAACCTTGTTGAAGCGGCAGCTGAAGCGTCAGAAGAATTAATGGAAAAATACTTAGGTGGT
GAAGACTTAACTGAAGAAGAAATTAAGTCAGCATTACGTCAGCGTGTATTAGCAAATGAAATTATTTTGGTAACCTGTGG
TTCTGCGTTCAAAAACAAAGGTGTTCAAGCAATGCTTGATGCAGTTGTTGAATACCTACCAGCACCAACTGATATTCCTG
CTATTAAAGGTATCAATCCAGATGAAACTGAAGGTGAGCGTCACGCAAGTGATGAAGAACCATTCTCTTCATTAGCATTT
AAAATTGCAACTGACCCATTCGTAGGTAACTTAACATTCTTCCGTGTATATTCTGGAGTGATTAATTCTGGAGATACAGT
ATTGAATTCTGTACGTCAAAAACGTGAACGTTTTGGCCGTATCGTACAGATGCACGCTAATAAACGTGAAGAAATTAAAG
AAGTTCGTGCAGGTGACATCGCAGCTGCTATCGGATTAAAAGATGTAACTACTGGTGATACATTATGTGCAATTGATGCA
CCAATTATCCTTGAGCGTATGGAATTCCCAGAGCCAGTAATCTCTGTTGCGGTAGAACCAAAAACTAAAGCTGACCAAGA
AAAAATGGGCTTAGCATTAGGTCGTTTAGCACAAGAAGACCCTTCATTCCGTGTTCACACAGATGAGGAATCTGGTGAAA
CCATTATTTCTGGTATGGGTGAGTTGCACTTAGATATCATTGTTGATCGTATGAAACGTGAGTTCAAAGTGGAAGCCAAT
ATTGGTAAACCACAAGTATCATACCGTGAAACTATCCGTACTCGTGTTAATGATGTAGAAGGTAAACACGCTAAACAATC
TGGTGGTCGCGGTCAATATGGTCATGTTGTTATCGACTTATACCCATTAGATCCAGAAGGCCCTGGTTATGAATTTGTAA
ACGAAATCAAAGGTGGTGTAATTCCTGGTGAATACATTCCAGCCGTTGATAAAGGTATTCAAGAACAACTTAAATCTGGT
CCATTAGCTGGTTACCCAGTAGTTGATCTTGGTGTACGTTTACACTTCGGTTCATACCATGATGTGGATTCATCTGAGTT
AGCATTTAAACTTGCTGCGTCTTTAGCATTTAAAGCAGCATTCTCAAAAGCAAACCCAGTATTACTTGAGCCAATTATGA
AAGTTGAAGTTGAAACTCCACCTGAATATGTTGGTGATGTAATTGGTGATTTAAGCCGTCGTCGTGCTATGGTTAACGGT
CAAGAAGCGAACGAGTTTGTTGTTAAAATCTATGCAGAAGTTCCACTTTCTGAGATGTTCGGTTATGCAACAGACTTACG
TTCACAAACTCAAGGTCGTGCATCATACTCAATGGAACCGTTAAAATATGCTGAAGCTCCAACAAGTGTGGCAGCTGCAG
TAATTGAAGCGCGTAAAAAATAA

Upstream 100 bases:

>100_bases
CTCACTACCGTTGGTAATAAGTTTTTGAATTTAAAGGGCTTCATCGTTGATGAAGCCTTACCCTTATATAAACTGATATT
AAATAAACAAGGTTATAATA

Downstream 100 bases:

>100_bases
TTTTTGTAAACCAGCGGTGTAAAATATGATTGTTTTATACCGCACTTCTTAGGAAACATTAGCAATGTCTAAAGAAAAAT
TTGAACGTACAAAACCGCAC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 700; Mature: 699

Protein sequence:

>700_residues
MARTTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMSQQFP
QHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYEVPRIAFVNKMDRTGANFLRVVEQLKT
RLGANAIPLQLPVGAEENFTGVVDLIKMKAINWNEADQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGG
EDLTEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINPDETEGERHASDEEPFSSLAF
KIATDPFVGNLTFFRVYSGVINSGDTVLNSVRQKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDA
PIILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMKREFKVEAN
IGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGVIPGEYIPAVDKGIQEQLKSG
PLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAAFSKANPVLLEPIMKVEVETPPEYVGDVIGDLSRRRAMVNG
QEANEFVVKIYAEVPLSEMFGYATDLRSQTQGRASYSMEPLKYAEAPTSVAAAVIEARKK

Sequences:

>Translated_700_residues
MARTTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMSQQFP
QHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYEVPRIAFVNKMDRTGANFLRVVEQLKT
RLGANAIPLQLPVGAEENFTGVVDLIKMKAINWNEADQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGG
EDLTEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINPDETEGERHASDEEPFSSLAF
KIATDPFVGNLTFFRVYSGVINSGDTVLNSVRQKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDA
PIILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMKREFKVEAN
IGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGVIPGEYIPAVDKGIQEQLKSG
PLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAAFSKANPVLLEPIMKVEVETPPEYVGDVIGDLSRRRAMVNG
QEANEFVVKIYAEVPLSEMFGYATDLRSQTQGRASYSMEPLKYAEAPTSVAAAVIEARKK
>Mature_699_residues
ARTTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMSQQFPQ
HRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYEVPRIAFVNKMDRTGANFLRVVEQLKTR
LGANAIPLQLPVGAEENFTGVVDLIKMKAINWNEADQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGGE
DLTEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINPDETEGERHASDEEPFSSLAFK
IATDPFVGNLTFFRVYSGVINSGDTVLNSVRQKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDAP
IILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMKREFKVEANI
GKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGVIPGEYIPAVDKGIQEQLKSGP
LAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAAFSKANPVLLEPIMKVEVETPPEYVGDVIGDLSRRRAMVNGQ
EANEFVVKIYAEVPLSEMFGYATDLRSQTQGRASYSMEPLKYAEAPTSVAAAVIEARKK

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=702, Percent_Identity=45.014245014245, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI19923640, Length=716, Percent_Identity=37.2905027932961, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI25306287, Length=697, Percent_Identity=35.7245337159254, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI25306283, Length=455, Percent_Identity=40.2197802197802, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI4503483, Length=405, Percent_Identity=30.1234567901235, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI157426893, Length=153, Percent_Identity=35.2941176470588, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI94966754, Length=138, Percent_Identity=39.1304347826087, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI310132016, Length=120, Percent_Identity=39.1666666666667, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI310110807, Length=120, Percent_Identity=39.1666666666667, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI310123363, Length=120, Percent_Identity=39.1666666666667, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1789738, Length=704, Percent_Identity=84.375, Blast_Score=1231, Evalue=0.0,
Organism=Escherichia coli, GI1790835, Length=493, Percent_Identity=26.9776876267748, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI48994988, Length=182, Percent_Identity=37.3626373626374, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788922, Length=161, Percent_Identity=35.4037267080745, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17533571, Length=700, Percent_Identity=43.8571428571429, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17556745, Length=737, Percent_Identity=30.2578018995929, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17506493, Length=437, Percent_Identity=28.8329519450801, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17557151, Length=169, Percent_Identity=37.8698224852071, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988819, Length=147, Percent_Identity=35.3741496598639, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988811, Length=147, Percent_Identity=35.3741496598639, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323098, Length=698, Percent_Identity=43.9828080229226, Blast_Score=562, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322359, Length=785, Percent_Identity=31.4649681528662, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324707, Length=439, Percent_Identity=28.4738041002278, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320593, Length=439, Percent_Identity=28.4738041002278, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323320, Length=177, Percent_Identity=35.0282485875706, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=174, Percent_Identity=32.7586206896552, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24582462, Length=703, Percent_Identity=44.5234708392603, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI221458488, Length=738, Percent_Identity=33.1978319783198, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI21357743, Length=778, Percent_Identity=23.1362467866324, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585709, Length=411, Percent_Identity=29.4403892944039, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585711, Length=411, Percent_Identity=29.4403892944039, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585713, Length=411, Percent_Identity=29.4403892944039, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78706572, Length=160, Percent_Identity=36.875, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574573, Length=171, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 77265; Mature: 77133

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERG
CCCCCHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTAFWSGMSQQFPQHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQ
EEEEEHHHHHHHHCHHHHCCHHCCEEEECCCCEEEEEEHHHHHHHHHHHHEEEEECCCCC
PQSETVWRQANKYEVPRIAFVNKMDRTGANFLRVVEQLKTRLGANAIPLQLPVGAEENFT
CCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCH
GVVDLIKMKAINWNEADQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGG
HHHHHHHHHCCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDLTEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINP
CCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
DETEGERHASDEEPFSSLAFKIATDPFVGNLTFFRVYSGVINSGDTVLNSVRQKRERFGR
CCCCCCCCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDAPIILERMEFPEPVISVAVEP
HHHHHCCCHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCHHEEEECC
KTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMKREFKVEAN
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHEEEECC
IGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGV
CCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCC
IPGEYIPAVDKGIQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAA
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHH
FSKANPVLLEPIMKVEVETPPEYVGDVIGDLSRRRAMVNGQEANEFVVKIYAEVPLSEMF
HCCCCCHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHH
GYATDLRSQTQGRASYSMEPLKYAEAPTSVAAAVIEARKK
HHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ARTTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERG
CCCCHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTAFWSGMSQQFPQHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGGVQ
EEEEEHHHHHHHHCHHHHCCHHCCEEEECCCCEEEEEEHHHHHHHHHHHHEEEEECCCCC
PQSETVWRQANKYEVPRIAFVNKMDRTGANFLRVVEQLKTRLGANAIPLQLPVGAEENFT
CCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCH
GVVDLIKMKAINWNEADQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGG
HHHHHHHHHCCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDLTEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINP
CCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCC
DETEGERHASDEEPFSSLAFKIATDPFVGNLTFFRVYSGVINSGDTVLNSVRQKRERFGR
CCCCCCCCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDAPIILERMEFPEPVISVAVEP
HHHHHCCCHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHCCCCCHHEEEECC
KTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMKREFKVEAN
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHEEEECC
IGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLDPEGPGYEFVNEIKGGV
CCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCC
IPGEYIPAVDKGIQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAA
CCCCCCCHHHHHHHHHHHCCCCCCCCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHH
FSKANPVLLEPIMKVEVETPPEYVGDVIGDLSRRRAMVNGQEANEFVVKIYAEVPLSEMF
HCCCCCHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHH
GYATDLRSQTQGRASYSMEPLKYAEAPTSVAAAVIEARKK
HHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA