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The map label for this gene is fkpA [C]

Identifier: 16272517

GI number: 16272517

Start: 593855

End: 594580

Strand: Direct

Name: fkpA [C]

Synonym: HI0574

Alternate gene names: 16272517

Gene position: 593855-594580 (Clockwise)

Preceding gene: 16272515

Following gene: 16272518

Centisome position: 32.45

GC content: 36.23

Gene sequence:

>726_bases
ATGTTAAAAATTCAAAAATTATCTATTGCAGCATTAATGGTAAGTGCGGTGATTTCTGGCCAAGTTTTTGCAGAAGATAA
CACATTCGATGAAAAAGCGGCATCTTATGCAGTAGGTACGCTCATGGGCAGTCAAATGAAAGATCTTGTTGATTCCCACA
AAGAAGTCATTAAATATGATAATGCGCGTATTTTAGATGGCTTAAAAGATGCTTTAGAAGGCAAAGTGGATGTTCGTAAA
GATGAAAAAATCCAAAAAACCTTAGAATCTATTGAAGCAAAATTAGTGGCTGCATCAAAAGCAAAAGCAGAATCGATTGC
TAAACAAGCAAAAGAAGAAGGCGATAAATTCCGTGCTGAATTTGCTAAAGGGAAAGATGTAAAAACGACGCAATCTGGTT
TAATGTATAAAATTGAAAGTGCAGGTAAAGGCGATACAATCAAATCAACGGATACCGTTAAAGTACATTACACGGGTAAA
TTACCAAATGGAAAAGTATTTGATAGCTCTGTCGAGCGCGGACAACCTGTAGAATTCCAACTTGATCAAGTAATTAAAGG
CTGGACTGAAGGTCTTCAATTAGTGAAAAAAGGCGGAAAAATTCAATTCGTTATTGCACCTGAATTAGGCTATGGCGAAC
AAGGTGCTGGTGCATCTATTCCACCAAATTCAACATTAATTTTTGATGTGGAAGTATTGGACGTCAATCCGAAATCTGAA
AAATAA

Upstream 100 bases:

>100_bases
CATAAATTTTCTCTAAATTCTAAAAAAAAGTTGAGAATAGATAGAAAGCCATTTAATCTATTCCTCGTATTATTCCATTC
ATTATAAAGGATTAACTTAT

Downstream 100 bases:

>100_bases
CGGATAAGTTTAATAGCGCGCGTTCTTTAACGCGTGCTTTTTATTATAAAAACGAGCGGAATTTTTACCGCACTTTTAAC
CTAACGCTATGACATTAAAC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGTLMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAESIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K

Sequences:

>Translated_241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGTLMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAESIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K
>Mature_241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGTLMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAESIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI224809329, Length=117, Percent_Identity=41.025641025641, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI224809327, Length=117, Percent_Identity=41.025641025641, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758384, Length=117, Percent_Identity=41.025641025641, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758380, Length=99, Percent_Identity=45.4545454545455, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI224809331, Length=116, Percent_Identity=41.3793103448276, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI17149836, Length=97, Percent_Identity=45.360824742268, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4503725, Length=97, Percent_Identity=45.360824742268, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=36.7521367521368, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503727, Length=107, Percent_Identity=38.3177570093458, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI8923659, Length=101, Percent_Identity=40.5940594059406, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI192448443, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=209, Percent_Identity=46.4114832535885, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082390, Length=210, Percent_Identity=41.9047619047619, Blast_Score=153, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71993519, Length=99, Percent_Identity=43.4343434343434, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=114, Percent_Identity=42.1052631578947, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=45.1612903225806, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=100, Percent_Identity=49, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=50, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=111, Percent_Identity=39.6396396396396, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=129, Percent_Identity=34.8837209302326, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=52.7472527472528, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=52.7472527472528, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24655568, Length=99, Percent_Identity=43.4343434343434, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=41.3461538461538, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647110, Length=115, Percent_Identity=40.8695652173913, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=48.4210526315789, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): FKBY_HAEIN (P44760)

Other databases:

- EMBL:   L42023
- PIR:   A64155
- RefSeq:   NP_438731.1
- ProteinModelPortal:   P44760
- SMR:   P44760
- GeneID:   949620
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0574
- NMPDR:   fig|71421.1.peg.544
- TIGR:   HI_0574
- HOGENOM:   HBG731200
- OMA:   QNADEMI
- ProtClustDB:   CLSK870457
- BioCyc:   HINF71421:HI_0574-MONOMER
- BRENDA:   5.2.1.8
- InterPro:   IPR001179
- InterPro:   IPR000774
- Gene3D:   G3DSA:1.10.287.460
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N

EC number: =5.2.1.8

Molecular weight: Translated: 26125; Mature: 26125

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGTLMGSQMKDLVDSHKEVIKYD
CCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NARILDGLKDALEGKVDVRKDEKIQKTLESIEAKLVAASKAKAESIAKQAKEEGDKFRAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGKLPNGKVFDSSVERGQPVEFQ
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCHHCCCCCCCCH
LDQVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCC
K
C
>Mature Secondary Structure
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGTLMGSQMKDLVDSHKEVIKYD
CCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NARILDGLKDALEGKVDVRKDEKIQKTLESIEAKLVAASKAKAESIAKQAKEEGDKFRAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGKLPNGKVFDSSVERGQPVEFQ
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCHHCCCCCCCCH
LDQVIKGWTEGLQLVKKGGKIQFVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023