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The map label for this gene is glmS

Identifier: 16272377

GI number: 16272377

Start: 451754

End: 453586

Strand: Reverse

Name: glmS

Synonym: HI0429

Alternate gene names: 16272377

Gene position: 453586-451754 (Counterclockwise)

Preceding gene: 30995375

Following gene: 16272374

Centisome position: 24.78

GC content: 39.28

Gene sequence:

>1833_bases
ATGTGTGGTATTGTCGGCGCAGTAGCACAACGAGATGTAGCGGAAATCTTAATTAATGGTTTACATCGTTTAGAATATCG
TGGTTATGATTCAGCTGGTGTTGCAGTAATCAATAAACAAAATGAATTACAACGTATTCGTTGTTTAGGCAAAGTTAAAG
CTTTAGATGAAGCCGTATCAGAAAAACCATTAATTGGTGGAACGGGAATTGCACATACCCGCTGGGCAACTCACGGCGAA
CCATCAGAAACTAATGCGCATCCGCATTCATCAGGTACTTTTGCTGTAGTACATAACGGTATTATTGAAAATCACGAAGA
ACTTCGCGAATTATTAAAATCTCGTGGTTATGTCTTTTTATCACAAACCGATACTGAAGTGATCGCGCATTTAGTTGAAT
GGGAAATGCGTACGACGGATTCACTTTTAGACGCTGTGAAAAAAGCAGTAAAACAACTCACTGGTGCATACGGTATGGTG
GTAATGGACAGCCGTCATCCTGAACATTTAGTGGCAGCTCGTTCTGGTAGTCCACTTGTGATTGGCTTAGGTATCGGTGA
AAATTTCTTAGCTTCAGATCAACTTGCGCTTTTAAGTGTTACCCGCCGTTTTATCTTTTTAGAAGAAGGAGATATTGCAG
AAATTACACGTCGTACAGTTGATATTTATGATACTCACGGTAATAAGGCTAAACGTGAAATTCACGAGTCTAATCTTGAA
AATGACGCGGCAGAGAAAGGCAAATTCCGTCATTTTATGCAGAAAGAAATTTACGAACAGCCAACCGCACTTATTAATAC
AATGGAAGGGCGTATCAATCACGAAAATGTGATTGTTGATTCAATCGGTAATGGTGCAAAAGGCATTTTAGAAAAAGTTG
AGCATATTCAAATTGTTGCTTGTGGTACATCTTATAATGCAGGTATGGTGGCGCGTTATTGGTTTGAATCTTTAGCTGGA
GTGAGCTGTGATGTTGAAATTGCATCAGAATTTCGTTATCGCAAATTTGTTACCCGTCCAAATAGCTTATTGATTACCCT
TTCTCAATCTGGCGAAACAGCCGATACTTTAGCTGCACTTCGTTTAGCGAAAGAAAAGGGCTATATGGCGGCATTAACAA
TTTGTAATGTTGCTGGCTCTTCGCTCGTACGCGAATCAGATCTTGCATTTATGACGCGTGCCGGTGTTGAAGTTGGGGTA
GCATCAACAAAAGCATTTACGACACAGCTCGCTGCGTTATTAATGTTGGTGACGGCACTTGGTAAAGTTAAAGGTCATAT
TTCTGTAGAAAAAGAACGTGAAATTATTAAAGCAATGCAATCTTTACCTGCTGAAATTGAAAAAGCGTTAGCTTTTGATA
CAGAAATTGAAGCTTTAGCAGAGGATTTTGCTGAAAAACATCATGCACTTTTCTTAGGTCGTGGTGCGTTTTATCCAATT
GCCGTAGAGGCCTCTTTGAAATTGAAAGAGATTTCTTATATTCACGCTGAGGCCTATGCGGCGGGAGAATTGAAACACGG
GCCATTAGCGTTAATTGATGCTGATATGCCAGTGATTGTCGTTGCACCAAATAATGAATTATTAGAAAAAGTAAAATCGA
ACATTGAGGAAGTGCGAGCTCGTGGCGGTCAATTATACGTATTTGCCGATAAAGAAGCAGGATTTACGCCAAGTGAAGGA
ATGAAAATCATCACGATGCCAAAAGTCAATGATATTGTTGCACCGATTTTTTATACCATTCCAATGCAATTACTTTCTTA
TTATGTGGCTTTAATTAAAGGTACTGATGTAGATCAACCTCGTAACTTAGCAAAATCAGTTACCGTTGAATAA

Upstream 100 bases:

>100_bases
AATGAAATGAAGCCCTGTCGATTGCGCAGGGGTTTTTTATTGTGTAAACGCGTGGCAAATGTAAAAACAAACTTAGTAAT
AGAATAAATAAGGAAAACTT

Downstream 100 bases:

>100_bases
AGTGCGGTTGATTTTAATGTAATAAAAAATACGGTGAAATTTCACCGTATTTTTTAGTTAAATAATCTTCTTTGTTTCCG
TGTTTTAATCACTTGTGCGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAQRDVAEILINGLHRLEYRGYDSAGVAVINKQNELQRIRCLGKVKALDEAVSEKPLIGGTGIAHTRWATHGE
PSETNAHPHSSGTFAVVHNGIIENHEELRELLKSRGYVFLSQTDTEVIAHLVEWEMRTTDSLLDAVKKAVKQLTGAYGMV
VMDSRHPEHLVAARSGSPLVIGLGIGENFLASDQLALLSVTRRFIFLEEGDIAEITRRTVDIYDTHGNKAKREIHESNLE
NDAAEKGKFRHFMQKEIYEQPTALINTMEGRINHENVIVDSIGNGAKGILEKVEHIQIVACGTSYNAGMVARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAALTICNVAGSSLVRESDLAFMTRAGVEVGV
ASTKAFTTQLAALLMLVTALGKVKGHISVEKEREIIKAMQSLPAEIEKALAFDTEIEALAEDFAEKHHALFLGRGAFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKVKSNIEEVRARGGQLYVFADKEAGFTPSEG
MKIITMPKVNDIVAPIFYTIPMQLLSYYVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAQRDVAEILINGLHRLEYRGYDSAGVAVINKQNELQRIRCLGKVKALDEAVSEKPLIGGTGIAHTRWATHGE
PSETNAHPHSSGTFAVVHNGIIENHEELRELLKSRGYVFLSQTDTEVIAHLVEWEMRTTDSLLDAVKKAVKQLTGAYGMV
VMDSRHPEHLVAARSGSPLVIGLGIGENFLASDQLALLSVTRRFIFLEEGDIAEITRRTVDIYDTHGNKAKREIHESNLE
NDAAEKGKFRHFMQKEIYEQPTALINTMEGRINHENVIVDSIGNGAKGILEKVEHIQIVACGTSYNAGMVARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAALTICNVAGSSLVRESDLAFMTRAGVEVGV
ASTKAFTTQLAALLMLVTALGKVKGHISVEKEREIIKAMQSLPAEIEKALAFDTEIEALAEDFAEKHHALFLGRGAFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKVKSNIEEVRARGGQLYVFADKEAGFTPSEG
MKIITMPKVNDIVAPIFYTIPMQLLSYYVALIKGTDVDQPRNLAKSVTVE
>Mature_610_residues
MCGIVGAVAQRDVAEILINGLHRLEYRGYDSAGVAVINKQNELQRIRCLGKVKALDEAVSEKPLIGGTGIAHTRWATHGE
PSETNAHPHSSGTFAVVHNGIIENHEELRELLKSRGYVFLSQTDTEVIAHLVEWEMRTTDSLLDAVKKAVKQLTGAYGMV
VMDSRHPEHLVAARSGSPLVIGLGIGENFLASDQLALLSVTRRFIFLEEGDIAEITRRTVDIYDTHGNKAKREIHESNLE
NDAAEKGKFRHFMQKEIYEQPTALINTMEGRINHENVIVDSIGNGAKGILEKVEHIQIVACGTSYNAGMVARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAALTICNVAGSSLVRESDLAFMTRAGVEVGV
ASTKAFTTQLAALLMLVTALGKVKGHISVEKEREIIKAMQSLPAEIEKALAFDTEIEALAEDFAEKHHALFLGRGAFYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKVKSNIEEVRARGGQLYVFADKEAGFTPSEG
MKIITMPKVNDIVAPIFYTIPMQLLSYYVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=38.9212827988338, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=38.3381924198251, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI29570798, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=72.2950819672131, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=228, Percent_Identity=29.8245614035088, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=40.2298850574713, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=40, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=40, Blast_Score=285, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=721, Percent_Identity=36.1997226074896, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=32.0185614849188, Blast_Score=203, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40.4878048780488, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=36.098981077147, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=28.1954887218045, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24659598, Length=269, Percent_Identity=27.1375464684015, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_HAEIN (P44708)

Other databases:

- EMBL:   L42023
- PIR:   D64067
- RefSeq:   NP_438590.1
- ProteinModelPortal:   P44708
- SMR:   P44708
- MEROPS:   C44.971
- GeneID:   950659
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0429
- NMPDR:   fig|71421.1.peg.403
- TIGR:   HI_0429
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   HINF71421:HI_0429-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66833; Mature: 66833

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILINGLHRLEYRGYDSAGVAVINKQNELQRIRCLGKVKALDEAVS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
EKPLIGGTGIAHTRWATHGEPSETNAHPHSSGTFAVVHNGIIENHEELRELLKSRGYVFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCEEEE
SQTDTEVIAHLVEWEMRTTDSLLDAVKKAVKQLTGAYGMVVMDSRHPEHLVAARSGSPLV
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCCEE
IGLGIGENFLASDQLALLSVTRRFIFLEEGDIAEITRRTVDIYDTHGNKAKREIHESNLE
EEECCCCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHEEEEEECCCCHHHHHHHHHCCC
NDAAEKGKFRHFMQKEIYEQPTALINTMEGRINHENVIVDSIGNGAKGILEKVEHIQIVA
CHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHEEEEEE
CGTSYNAGMVARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAALTICNVAGSSLVRESDLAFMTRAGVEVGVASTKAFTTQLAALLMLVTAL
HHHHHCCCEEEEHHHHHHCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKVKGHISVEKEREIIKAMQSLPAEIEKALAFDTEIEALAEDFAEKHHALFLGRGAFYPI
HHHCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCEEEEECCCCEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKVKSNIEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGQLYVFADKEAGFTPSEGMKIITMPKVNDIVAPIFYTIPMQLLSYYVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILINGLHRLEYRGYDSAGVAVINKQNELQRIRCLGKVKALDEAVS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
EKPLIGGTGIAHTRWATHGEPSETNAHPHSSGTFAVVHNGIIENHEELRELLKSRGYVFL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCEEEE
SQTDTEVIAHLVEWEMRTTDSLLDAVKKAVKQLTGAYGMVVMDSRHPEHLVAARSGSPLV
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCCCCEE
IGLGIGENFLASDQLALLSVTRRFIFLEEGDIAEITRRTVDIYDTHGNKAKREIHESNLE
EEECCCCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHEEEEEECCCCHHHHHHHHHCCC
NDAAEKGKFRHFMQKEIYEQPTALINTMEGRINHENVIVDSIGNGAKGILEKVEHIQIVA
CHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHEEEEEE
CGTSYNAGMVARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAALTICNVAGSSLVRESDLAFMTRAGVEVGVASTKAFTTQLAALLMLVTAL
HHHHHCCCEEEEHHHHHHCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKVKGHISVEKEREIIKAMQSLPAEIEKALAFDTEIEALAEDFAEKHHALFLGRGAFYPI
HHHCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCEEEEECCCCEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKVKSNIEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGQLYVFADKEAGFTPSEGMKIITMPKVNDIVAPIFYTIPMQLLSYYVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800