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The map label for this gene is galE

Identifier: 16272302

GI number: 16272302

Start: 378043

End: 379059

Strand: Reverse

Name: galE

Synonym: HI0351

Alternate gene names: 16272302

Gene position: 379059-378043 (Counterclockwise)

Preceding gene: 16272303

Following gene: 16272301

Centisome position: 20.71

GC content: 38.84

Gene sequence:

>1017_bases
ATGGCCATTTTAGTGACGGGTGGCGCTGGTTATATCGGTTCTCACACAGTTGTAGAATTATTAAATGTTGGCAAAGAGGT
GGTGGTATTAGATAATCTTTGCAATTCATCGCCAAAATCCCTTGAGCGCGTAAAACAAATTACAGGCAAAGAAGCAAAGT
TTTATGAAGGCGATATTTTAGATCGTGCTTTGTTACAAAAAATTTTTGCAGAAAATGAGATTAACTCGGTTATTCACTTT
GCAGGGTTAAAAGCCGTAGGGGAAAGTGTTCAAAAGCCGACAGAATATTACATGAACAATGTCGCTGGCACCCTTGTATT
AATTCAAGAAATGAAAAAAGCAGGTGTTTGGAACTTTGTATTTAGCTCATCTGCAACGGTTTACGGCGATCCAAAAATTA
TTCCAATTACAGAGGATTGTGAAGTCGGCGGTACAACCAACCCTTATGGTACATCTAAATATATGGTTGAGCAGATTTTA
CGCGATACAGCAAAAGCGGAACCAAAATTTAGCATGACTATCTTGCGTTATTTTAATCCAGTTGGGGCGCATGAAAGTGG
CTTGATTGGTGAAGATCCAAATGGTATTCCAAATAATTTATTACCTTATATTAGCCAAGTTGCTATCGGTAAATTAGCAC
AACTTTCTGTATTTGGTAGTGATTACGACACTCATGATGGAACAGGTGTGCGTGATTATATTCATGTAGTGGATTTAGCT
GTGGGGCATTTAAAAGCGCTTCAACGTCATGAAAATGACGCTGGCTTACATATTTATAACCTTGGTACGGGCCATGGTTA
TTCCGTATTAGATATGGTAAAAGCCTTTGAAAAAGCCAACAATATTACAATTGCATATAAACTTGTAGAACGCCGCTCTG
GCGATATTGCCACTTGCTATTCTGATCCTAGTTTAGCGGCAAAAGAGCTTGGTTGGGTGGCAGAACGTGGTCTTGAAAAA
ATGATGCAAGACACGTGGAACTGGCAGAAAAATAATCCAAAAGGGTATAGAGATTAA

Upstream 100 bases:

>100_bases
TTTTTAGCAACAGGTTTTTTATTTTATTGAAAATCACCATTCTTACCACACAAAATAGTGATATAATTTTTTAGTCTCAA
TAATTAACAAGGAAATCATT

Downstream 100 bases:

>100_bases
TATTCTCTAATATTTGTTTTTCTTTTTTAGGAAGAAGAATGCTAAACATTAGGGGAATGATTAAAAATCCCCTAATTTTT
ACAAAAATCCTTTAATTGAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
RDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD

Sequences:

>Translated_338_residues
MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
RDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD
>Mature_337_residues
AILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHFA
GLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILR
DTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLAV
GHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEKM
MQDTWNWQKNNPKGYRD

Specific function: By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI7657641, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=57.6923076923077, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=26.158038147139, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI48994969, Length=364, Percent_Identity=27.7472527472527, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=57.9710144927536, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=57.6368876080692, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17568069, Length=283, Percent_Identity=27.9151943462898, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=53.4883720930233, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=59.3567251461988, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_HAEIN (P24325)

Other databases:

- EMBL:   X57315
- EMBL:   L42023
- PIR:   A64063
- RefSeq:   NP_438515.1
- ProteinModelPortal:   P24325
- SMR:   P24325
- GeneID:   949642
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0351
- NMPDR:   fig|71421.1.peg.328
- TIGR:   HI_0351
- HOGENOM:   HBG755066
- OMA:   VGESTTI
- ProtClustDB:   CLSK870036
- BioCyc:   HINF71421:HI_0351-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 37166; Mature: 37034

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 149-149 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
CEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHCCCCEEEEE
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
EEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHCCCCEEEEE
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1956282; 7542800