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The map label for this gene is mtr

Identifier: 16272242

GI number: 16272242

Start: 321135

End: 322391

Strand: Direct

Name: mtr

Synonym: HI0287

Alternate gene names: 16272242

Gene position: 321135-322391 (Clockwise)

Preceding gene: 16272241

Following gene: 16272248

Centisome position: 17.55

GC content: 39.14

Gene sequence:

>1257_bases
ATGATACAACAAAAATCTCCTTCTCTCTTAGGCGGTGCAATGATCATTGCAGGTACAGCGATTGGTGCAGGCATGCTGGC
TAACCCAACTTCAACGGCAGGTGTATGGTTTATCGGTTCAATTCTTGCTTTAATTTATACTTGGTTTTGTATGACAACCT
CAGGATTAATGATCCTAGAAGCTAATCTACATTATCCAACAGGTTCAAGTTTTGACACTATCGTTAAAGATTTATTAGGA
AAAAGTTGGAATACTATCAATGGTCTTTCTGTTGCTTTCGTCTTGTATATTTTGACTTATGCCTACATAACCTCAGGCGG
AGGCATTACACAGAATCTGCTCAACCAAGCATTCAGTTCTGCTGAAAGTGCGGTAGATATTGGGCGAACTTCAGGATCTT
TAATTTTCTGCCTTATTCTTGCAGCCTTTGTATGGCTTTCAACCAAAGCAGTGGATCGTTTCACAACCGTGTTAATTGTC
GGGATGGTGGTTGCTTTTTTCCTTTCTACTACTGGTTTATTAAGCTCTGTAAAAACAGCAGTTTTATTCAATACCGTTGC
TGAAAGTGAGCAAACATATTTACCTTATTTATTGACCGCACTTCCAGTTTGTCTCGTGTCGTTTGGTTTCCACGGAAATG
TCCCGAGTCTCGTCAAATATTACGATCGTGATGGTCGTCGCGTGATGAAATCGATCTTTATTGGTACAGGCTTAGCATTA
GTGATTTACATCTTATGGCAGCTCGCTGTACAAGGTAATTTACCACGCACTGAATTTGCGCCAGTCATTGAAAAAGGCGG
CGATGTTTCTGCATTATTAGAGGCTTTACATAAATATATTGAAGTGGAATACCTTTCCGTCGCATTAAATTTCTTTGCTT
ATATGGCAATTTCTACTTCATTCTTAGGCGTCACTTTAGGGTTATTTGACTATATTGCGGATCTATTTAAATTTGACGAT
AGCTTATTAGGCAGAACAAAAACAACACTTGTTACTTTTTTACCGCCATTATTGCTAAGCCTGCAATTTCCTTATGGATT
TGTGATTGCCATTGGTTACGCTGGATTGGCGGCAACAATTTGGGCTGCAATTGTCCCCGCACTTCTTGCCAAAGCAAGCC
GTCAAAAATTCCCACAAGCAAGTTATAAAGTATACGGCGGAAATTTTATGATTGGTTTTGTAATTTTATTTGGCATATTA
AATATTGTGGCGCAAATTGGGGCAAACTTAGGTTGGTTTGCAAGTTTTACTGGGTAA

Upstream 100 bases:

>100_bases
ATTACAAAGGGGACTAAATGTCCCCTTTTTATCGATATAAATATATTGCACTTTCCTTGTGTACTACTATAATAGTGCAA
ATTTATTTTAGAGGCATTTT

Downstream 100 bases:

>100_bases
GTTTTAAAAAATAAATTTAAATTATTAAATAGCGATCTGCACTTTAACAGTGGGTTATGTAGTCCAACTAATTCGTGTAG
ATCAGCCCCTTAATTATTTT

Product: tryptophan-specific transport protein

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLG
KSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIV
GMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLAL
VIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDD
SLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGIL
NIVAQIGANLGWFASFTG

Sequences:

>Translated_418_residues
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLG
KSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIV
GMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLAL
VIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDD
SLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGIL
NIVAQIGANLGWFASFTG
>Mature_418_residues
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLG
KSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIV
GMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLAL
VIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDD
SLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGIL
NIVAQIGANLGWFASFTG

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily

Homologues:

Organism=Escherichia coli, GI1789552, Length=403, Percent_Identity=55.0868486352357, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1790145, Length=405, Percent_Identity=45.1851851851852, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1788218, Length=396, Percent_Identity=37.8787878787879, Blast_Score=245, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTR_HAEIN (P44614)

Other databases:

- EMBL:   L42023
- PIR:   F64059
- RefSeq:   NP_438454.1
- GeneID:   949413
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0287
- NMPDR:   fig|71421.1.peg.269
- TIGR:   HI_0287
- HOGENOM:   HBG482321
- OMA:   YAYITSG
- ProtClustDB:   CLSK870392
- BioCyc:   HINF71421:HI_0287-MONOMER
- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227
- PRINTS:   PR00166
- TIGRFAMs:   TIGR00837

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 45018; Mature: 45018

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb28bb2c)-; HASH(0xc9b6dec)-; HASH(0xbd30db8)-; HASH(0xc40f634)-; HASH(0xb19abcc)-; HASH(0xc6379a8)-; HASH(0x405c79bc)-; HASH(0xbc7bf10)-; HASH(0xbe659e8)-; HASH(0xc732f24)-; HASH(0xc7270bc)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILE
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSS
ECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGLLSSVKTA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTS
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
WAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGILNIVAQIGANLGWFASFTG
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCH
>Mature Secondary Structure
MIQQKSPSLLGGAMIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILE
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSS
ECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGLLSSVKTA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYILWQLAVQGNLPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTS
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATI
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
WAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVILFGILNIVAQIGANLGWFASFTG
HHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800