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The map label for this gene is yggV [C]

Identifier: 16272217

GI number: 16272217

Start: 289511

End: 290098

Strand: Reverse

Name: yggV [C]

Synonym: HI0260

Alternate gene names: 16272217

Gene position: 290098-289511 (Counterclockwise)

Preceding gene: 16272218

Following gene: 16272216

Centisome position: 15.85

GC content: 39.8

Gene sequence:

>588_bases
ATGAAACAAAAAATCGTACTTGCTACAGGCAATAAAGGAAAAGTAAAAGAAATGGCTGATGTCCTATCTGATTTTGGCTT
TGAAGTGATTGCACAAACAGATTTAGGCATTGAAAGCCCAGAAGAGACAGGCTTAACTTTTGTAGAGAATGCCTTATTAA
AAGCCCGTTATGCCTCAGAGAAATCAGGTTTACCTGCTATTGCAGATGATTCTGGCTTAGTAGTTTCCGCACTTAATGGC
GCACCAGGTCTGTATTCTGCCCGTTATGCTGGTGAAGAGGGCAATGATGCTAAAAACCGTGAGAAATTATTGGCAGAGCT
TGCTCATATTGCACAAGAACAACGCCAAGCCAAATTTGTGAGCTGTATCGTGTTTTTACAGCATCCAACGGATCCATCGC
CAATTATCGCCGAAGGTGAGTGTTGTGGCGTGATTGGTTTTGAAGAAAAAGGCGAAAATGGCTTTGGTTATGACAGTTTA
TTCTTTAGTCCAGAACAAGGTTGCACATTTGCTGAATTAGAAACAGCTGAGAAGAAAAAAATTTCTCATCGAGCAAAGGC
ATTGAGTGTTTTAAAAAGTAAATTATAA

Upstream 100 bases:

>100_bases
AACGTTCCTTCGAAAAAGAAGTTGGACGAATGAATATTCAATTTACCGAGCAAAACTGGGCTGATTTAACGTCAGCTTAT
CATCAATAAAAGGACTAATT

Downstream 100 bases:

>100_bases
AGTAAATAAAATTATTTAATCTATCAAAAAAATAACCCAAAAAATAATAATTCACACGTTAATCAGAGATAATTTCATGA
CAGACAGACAGACAGACAGA

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASEKSGLPAIADDSGLVVSALNG
APGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFVSCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSL
FFSPEQGCTFAELETAEKKKISHRAKALSVLKSKL

Sequences:

>Translated_195_residues
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASEKSGLPAIADDSGLVVSALNG
APGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFVSCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSL
FFSPEQGCTFAELETAEKKKISHRAKALSVLKSKL
>Mature_195_residues
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASEKSGLPAIADDSGLVVSALNG
APGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFVSCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSL
FFSPEQGCTFAELETAEKKKISHRAKALSVLKSKL

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Escherichia coli, GI1789324, Length=193, Percent_Identity=56.4766839378238, Blast_Score=233, Evalue=8e-63,
Organism=Drosophila melanogaster, GI19920712, Length=193, Percent_Identity=30.5699481865285, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_HAEIN (P44598)

Other databases:

- EMBL:   L42023
- PIR:   D64146
- RefSeq:   NP_438428.1
- ProteinModelPortal:   P44598
- SMR:   P44598
- GeneID:   949383
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0260
- NMPDR:   fig|71421.1.peg.244
- TIGR:   HI_0260
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- ProtClustDB:   PRK00120
- BioCyc:   HINF71421:HI_0260-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 20972; Mature: 20972

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASE
CCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHH
KSGLPAIADDSGLVVSALNGAPGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFV
CCCCCEEECCCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSLFFSPEQGCTFAELETAEKKK
HHHEEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
ISHRAKALSVLKSKL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQKIVLATGNKGKVKEMADVLSDFGFEVIAQTDLGIESPEETGLTFVENALLKARYASE
CCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHHHHHHHHH
KSGLPAIADDSGLVVSALNGAPGLYSARYAGEEGNDAKNREKLLAELAHIAQEQRQAKFV
CCCCCEEECCCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SCIVFLQHPTDPSPIIAEGECCGVIGFEEKGENGFGYDSLFFSPEQGCTFAELETAEKKK
HHHEEEECCCCCCCEEECCCEEEEECCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
ISHRAKALSVLKSKL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023