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The map label for this gene is nhaA [H]

Identifier: 16272188

GI number: 16272188

Start: 254272

End: 255474

Strand: Reverse

Name: nhaA [H]

Synonym: HI0225

Alternate gene names: 16272188

Gene position: 255474-254272 (Counterclockwise)

Preceding gene: 16272190

Following gene: 16272186

Centisome position: 13.96

GC content: 36.49

Gene sequence:

>1203_bases
GTGAATTTTTTGCTATGTATTTTTAAAGGGGTTTATGTGATAAAACTGATCCAACGTTTTTTTAAATTAGAATCTGCTGG
CGGTATATTATTGCTTTTTTCAGCTGTTGTTGCGATGTTGCTGGCTAATTCGCCGTTAAGCAACCAATATAATGATTTTT
TAAATTTGCCTGTAAGTTTACAAATTGGTAGTTTCTCAATTAATAAAACCTTAATTCACTGGATTAACGATGGTTTTATG
GCGGTGTTTTTTGTATTAGTGGGAATGGAAGTCAAAAAAGAATTATTTGAAGGCGCGCTTTCTACCTATCAACAAGCTAT
TTTCCCTGCTATTGCAGCTATTGGCGGAATGGTTATACCGGCTGTAGTTTATTGGTTTATCGCTAAACAAGATCCAAGTT
TAGCTAATGGCTGGGCAATTCCAATGGCAACAGACATTGCTTTTGCACTGGGAATTATGGCGTTATTGAGTAAACAAGTG
CCACTTCCACTGAAAATATTTTTACTTGCCCTTGCTATTATTGATGACCTCGGTGCGATAGTTGTTATTGCATTATTTTT
CTCGCACGGATTGAGTGTGCAAGCACTAATTTTTTCTGCCGTGGCAATTATTGTGCTGATATTACTAAATCGTTTCAGAG
TTTCTGCACTTTGCGCTTATATGGTCGTAGGTGCAATTTTATGGGCTTCCGTATTAAAGTCTGGTGTGCATGCTACTTTA
GCAGGCGTTATTATTGGTTTTAGCATTCCATTGAAAGGTAAAAAAGGAGAACGCCCATTAGATGATTTCGAGCATATTTT
AGCCTCTTGGTCATCTTTCGTTATTTTACCACTTTTCGCATTTGCCAATGCTGGTGTGAGTTTTGCAGGCATAGATGTGA
ATATGATTTCGTCGCCATTATTATTGGCTATAGCAAGCGGTTTAATTATTGGTAAACCAGTCGGTATATTTGGATTTAGT
TATATTTCTGTTAAATTGGGATTAGCTAAATTACCGGATGGAATTAATTTTAAACAAATTTTTGCTGTTGCGGTTTTATG
TGGAATCGGTTTTACGATGTCAATGTTCTTAGCAAGCCTTGCGTTTGATGCTAATGCGGGGGAAAGTGTCAATACTCTTT
CTCGTTTAGGTATTCTACTTGGATCAACGGTTTCGGCAATACTTGGGTATTTATTCTTAAAACAAACGACAAAACTAAAC
TAA

Upstream 100 bases:

>100_bases
TCACAATATATGGCATTTTATCGACAATTCGCTAAAAATCCCGACAAAATCTACCGCACTTTTTCCTTTAACTTCGAAAA
TATGCTAGGATGCTTCCTTT

Downstream 100 bases:

>100_bases
TCATACACAAAGTGCGGTAAAAATTTACCGCACTTGTTCTATAAGATAATTCCACTATCTGCTTTGGTAAAATTCATTAC
AAATAAACTTTTATAAGTTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIVLILLNRFRVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILLGSTVSAILGYLFLKQTTKLN

Sequences:

>Translated_400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIVLILLNRFRVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILLGSTVSAILGYLFLKQTTKLN
>Mature_400_residues
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSLQIGSFSINKTLIHWINDGFM
AVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIPAVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQV
PLPLKIFLLALAIIDDLGAIVVIALFFSHGLSVQALIFSAVAIIVLILLNRFRVSALCAYMVVGAILWASVLKSGVHATL
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPLLLAIASGLIIGKPVGIFGFS
YISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASLAFDANAGESVNTLSRLGILLGSTVSAILGYLFLKQTTKLN

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=54.7120418848168, Blast_Score=378, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42764; Mature: 42764

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEE
QIGSFSINKTLIHWINDGFMAVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIP
EECCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQVPLPLKIFLLALAIIDDLGAI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VVIALFFSHGLSVQALIFSAVAIIVLILLNRFRVSALCAYMVVGAILWASVLKSGVHATL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
LLAIASGLIIGKPVGIFGFSYISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AFDANAGESVNTLSRLGILLGSTVSAILGYLFLKQTTKLN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFLLCIFKGVYVIKLIQRFFKLESAGGILLLFSAVVAMLLANSPLSNQYNDFLNLPVSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEE
QIGSFSINKTLIHWINDGFMAVFFVLVGMEVKKELFEGALSTYQQAIFPAIAAIGGMVIP
EECCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVYWFIAKQDPSLANGWAIPMATDIAFALGIMALLSKQVPLPLKIFLLALAIIDDLGAI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VVIALFFSHGLSVQALIFSAVAIIVLILLNRFRVSALCAYMVVGAILWASVLKSGVHATL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVIIGFSIPLKGKKGERPLDDFEHILASWSSFVILPLFAFANAGVSFAGIDVNMISSPL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
LLAIASGLIIGKPVGIFGFSYISVKLGLAKLPDGINFKQIFAVAVLCGIGFTMSMFLASL
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AFDANAGESVNTLSRLGILLGSTVSAILGYLFLKQTTKLN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA