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The map label for this gene is guaA [H]

Identifier: 16272185

GI number: 16272185

Start: 251125

End: 252696

Strand: Direct

Name: guaA [H]

Synonym: HI0222

Alternate gene names: 16272185

Gene position: 251125-252696 (Clockwise)

Preceding gene: 16272184

Following gene: 30995364

Centisome position: 13.72

GC content: 43.58

Gene sequence:

>1572_bases
ATGACAAATATCCACTATCACAAAATCCTAATCCTCGACTTTGGTTCACAATACACTCAACTGATTGCGCGTCGTGTGCG
TGAAATCGGTGTGTACTGCGAACTTTGGGCTTGGGATGTAACCGAACAACAAATCCGTGAATTTGCTCCAACGGGTATCA
TTCTTTCTGGCAGTCCTGAAAGCACAACTGAAGAAAATAGCCCTCGTGCACCGGAATATGTATTTAATGCTGGTGTACCA
GTATTAGGCATTTGCTATGGAATGCAAACGATGGCGATGCAACTTGGCGGCTTAACCGAAACGTCTGATCACAGAGAGTT
CGGCTATGCTTCCGTTTCTCTTGAAAATTCCACCGCACTTTTTGCAAATCTTAACGATAATTTAACCGCTTCTGAGCCAA
AATTAGACGTTTGGATGAGCCACGGCGATAAGGTAACGCGCTTACCAGAAAACTTCAAAGTAACTGGCACAACGCTAACC
TGCCCAATTGCTGCGATGTCTGATGAAAGCCGTCGTTTCTACGGTGTGCAGTTCCACCCTGAAGTAACGCATACTAAAAA
AGGCTTGGAATTATTAACCAACTTCGTAGTAAACATCTGTGGTTGCGAAACCAAATGGACAGCAGAAAACATTATCGAAG
ATGCCGTTGCTCGCATTAAAGAGCAAGTGGGCGATGATGAAGTGATTTTAGGCTTATCTGGTGGTGTGGACTCTTCTGTG
GTTGCATTACTTTTACACCGTGCTATCGGCAAAAACTTACACTGCGTATTTGTGGATAACGGTTTACTCCGCTTACACGA
AGGCGACCAAGTCATGGAAATGTTTGGCGATAAATTCGGTTTAAACATCACTCGTGTTGATGCTGAAAGTCGTTTCTTAG
GTGAACTTGCAGGCGTATCTGATCCTGAAGCGAAACGTAAAATTATCGGTAAAGTGTTCGTGGATGTATTCGATGATGAA
TCGAAAAAACTCACTAATGTGAAATGGTTGGCACAAGGTACGATTTACCCTGACGTAATCGAATCTGCAGCAAGCAAAAC
TGGTAAAGCACATGTGATTAAATCACACCACAACGTAGGTGGCTTACCAGACTATATGAAACTTGGTTTAGTTGAACCTT
TACGTGAATTATTTAAAGATGAAGTACGTAAAATCGGTTTAGCATTAGGCTTACCAGCTGAAATGATCAACCGCCACCCA
TTCCCTGGCCCAGGCTTAGGTGTGCGTGTATTAGGCGAAGTGAAAAAAGAATACTGCGATTTATTACGCCGTGCGGATGC
GATCTTTATCGAAGAATTACGCAACAGCGGTTGGTATGAAAAAACCAGCCAAGCCTTCAGCGTATTCTTACCAGTGAAAT
CTGTAGGTGTGATGGGCGATGGCCGTAAATACGATTGGGTTATTTCCCTACGCGCGGTAGAAACAATCGATTTTATGACC
GCACATTGGGCACATTTGCCTTATGATTTATTAGGCAAAGTGTCTAACCGTATCATCAACGAAGTGAATGGAATTTCCCG
CGTCGTATACGACATCAGCGGAAAACCACCCGCAACAATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TGGGCTTTAGCCTGCCTTTTGCTGTTTAAAGTGCGGTTGGTTTTTGCAAAGTTTTAAATAATATGAACCGCTTACACTAT
CAATAATAAGAGCATTATAA

Downstream 100 bases:

>100_bases
AAAATCACTTTTTCAGATACTTTCTAATTATTTCAGTAACTTTAATAAGTGCGGTTAATTTTCACCGCACTTTCTTTTTG
TTTAAAAGCCCTTCTATGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MTNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLT
CPIAAMSDESRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSV
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDE
SKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHP
FPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Sequences:

>Translated_523_residues
MTNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLT
CPIAAMSDESRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSV
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDE
SKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHP
FPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
>Mature_522_residues
TNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPESTTEENSPRAPEYVFNAGVPV
LGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTC
PIAAMSDESRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSVV
ALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDES
KKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPF
PGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMTA
HWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=569, Percent_Identity=35.3251318101933, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=78.1609195402299, Blast_Score=862, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=35.8260869565217, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=35.8260869565217, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=35.8260869565217, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=49.5256166982922, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=36.3636363636364, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58186; Mature: 58055

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPE
CCCCEEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
STTEENSPRAPEYVFNAGVPVLGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTAL
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEE
FANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTCPIAAMSDESRRFYGVQFHP
EEECCCCCCCCCCCEEEEECCCCEEEECCCCCEEECEEEEEEEEECCCCCCEEEEEEECC
EVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVS
HHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHCCHHHCCEEEEECCHHHHHHHHCCCC
DPEAKRKIIGKVFVDVFDDESKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPFPGPGLGVRVLGEVKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPE
CCCEEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
STTEENSPRAPEYVFNAGVPVLGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTAL
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEE
FANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLTCPIAAMSDESRRFYGVQFHP
EEECCCCCCCCCCCEEEEECCCCEEEECCCCCEEECEEEEEEEEECCCCCCEEEEEEECC
EVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVS
HHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHCCHHHCCEEEEECCHHHHHHHHCCCC
DPEAKRKIIGKVFVDVFDDESKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHPFPGPGLGVRVLGEVKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA