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The map label for this gene is fabD

Identifier: 16272123

GI number: 16272123

Start: 172161

End: 173099

Strand: Reverse

Name: fabD

Synonym: HI0156

Alternate gene names: 16272123

Gene position: 173099-172161 (Counterclockwise)

Preceding gene: 16272124

Following gene: 16272122

Centisome position: 9.46

GC content: 41.85

Gene sequence:

>939_bases
ATGAAAAAATTCGCAATGGTCTTCCCAGGTCAAGGCTCCCAAACTGTCGGTATGCTTGCTGATCTTGCAACTGAATATCC
AATCGTTATTGAAACATTTAAACAAGCATCTGATGCGCTTGGTTATGATTTATGGTATCTTGTTCAACAAGGTCCAGCTG
AAGAACTTAATAAAACTTGGCAAACTCAGCCCGCACTTTTAGCTGCTTCAGTCGCTATTTATCGCGTATGGAAAGAAAAA
TTTCCTCAATTAAAACCAGAAGTGATGGCAGGTCATAGCTTAGGTGAGTATTCTGCGTTAGTTTGTGCTGGCGTGTTGGA
TTTCCAAGATGCGATTAAATTAGTGGAATTGCGCGGAAAATTAATGCAACAAGCTGTGCCTGAAGGCACTGGCGCAATGT
ATGCAATCATTGGTTTAGATAATGAAGCAATTATTAATGCTTGCAAACAAGCAGAGGAAGGCGAAGTCGTATCTGCGGTG
AACTTTAACTCACCGGGTCAAGTAGTTATTGCGGGTGCGAAAGCTGCAGTTGAGCGTGCGGCTGCATTATGTAAAGAAGC
AGGGGCGAAACGTGCATTGCCGTTAGCTGTGAGCGTACCTTCTCACTGTGCATTAATGAAACCTGCAGCCGAGCAATTAG
CGGTAACACTTGAGAATATTCAAATTAATACACCAACAATATCGGTATTAAATAACGTTGATGTGAAAGCTGAAACTGAA
GGCACCGAAATTCGTACCGCACTTGTGCGTCAGTTATATAGTCCAGTTCGTTGGACTGAAACAGTTGAAAAAATGGCGCA
AGATGGCGTTCTAGTGCTTGCTGAAGTGGGGCCAGGTAAAGTATTAAATGGTTTAACCAAACGCATTGTGGGTGATTTAC
AAGCAATATCTGTAAATGATGTTGCATCATTCAATGCGGTAGAAGAATTTTTAGTGTAA

Upstream 100 bases:

>100_bases
TCTTTGGCGAAGCAAAGAAAAAGTAAGCTCGCCATCGGCGAAACCCGATTTTAATTACCGAAGAAGAATTTTCAATTAAA
AAACAATAGGACAAAACATA

Downstream 100 bases:

>100_bases
GTAAAAGGAAGAAAAAATGCAAGGTAAAATTGCTTTAGTGACAGGATCTACCCGTGGTATCGGTCGTGCGATTGCAGAAG
AACTTAGTTCAAAAGGTGCA

Product: acyl carrier protein S-malonyltransferase

Products: NA

Alternate protein names: MCT

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQQGPAEELNKTWQTQPALLAASVAIYRVWKEK
FPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAV
NFNSPGQVVIAGAKAAVERAAALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVKAETE
GTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAISVNDVASFNAVEEFLV

Sequences:

>Translated_312_residues
MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQQGPAEELNKTWQTQPALLAASVAIYRVWKEK
FPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAV
NFNSPGQVVIAGAKAAVERAAALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVKAETE
GTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAISVNDVASFNAVEEFLV
>Mature_312_residues
MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQQGPAEELNKTWQTQPALLAASVAIYRVWKEK
FPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAV
NFNSPGQVVIAGAKAAVERAAALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVKAETE
GTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAISVNDVASFNAVEEFLV

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family

Homologues:

Organism=Homo sapiens, GI51243059, Length=300, Percent_Identity=34.3333333333333, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI27477045, Length=111, Percent_Identity=44.1441441441441, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787334, Length=310, Percent_Identity=70.9677419354839, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71984332, Length=292, Percent_Identity=31.5068493150685, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=296, Percent_Identity=28.3783783783784, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24665753, Length=311, Percent_Identity=33.1189710610932, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): FABD_HAEIN (P43712)

Other databases:

- EMBL:   L42023
- PIR:   E64051
- RefSeq:   NP_438326.1
- ProteinModelPortal:   P43712
- SMR:   P43712
- GeneID:   951062
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0156
- NMPDR:   fig|71421.1.peg.147
- TIGR:   HI_0156
- HOGENOM:   HBG687898
- OMA:   FKDAVPL
- ProtClustDB:   CLSK870664
- BioCyc:   HINF71421:HI_0156-MONOMER
- BRENDA:   2.3.1.39
- GO:   GO:0005488
- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036
- Gene3D:   G3DSA:3.40.366.10
- TIGRFAMs:   TIGR00128

Pfam domain/function: PF00698 Acyl_transf_1; SSF52151 Acyl_Trfase/lysoPlipase; SSF55048 Malonyl_transacylase_ACP-bd

EC number: =2.3.1.39

Molecular weight: Translated: 33425; Mature: 33425

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: ACT_SITE 93-93 ACT_SITE 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQQGPAEELNKTW
CCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHH
QTQPALLAASVAIYRVWKEKFPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVELRGK
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEECHHHHHHHH
AALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVKAETE
HHHHHHCCCCCCCEEEEECCCCHHHHCHHHHHHHEEHHHEEECCCEEEEECCCCCEECCC
GTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAISVND
CHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEHHH
VASFNAVEEFLV
HHHHHHHHHHCC
>Mature Secondary Structure
MKKFAMVFPGQGSQTVGMLADLATEYPIVIETFKQASDALGYDLWYLVQQGPAEELNKTW
CCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHH
QTQPALLAASVAIYRVWKEKFPQLKPEVMAGHSLGEYSALVCAGVLDFQDAIKLVELRGK
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMQQAVPEGTGAMYAIIGLDNEAIINACKQAEEGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEECHHHHHHHH
AALCKEAGAKRALPLAVSVPSHCALMKPAAEQLAVTLENIQINTPTISVLNNVDVKAETE
HHHHHHCCCCCCCEEEEECCCCHHHHCHHHHHHHEEHHHEEECCCEEEEECCCCCEECCC
GTEIRTALVRQLYSPVRWTETVEKMAQDGVLVLAEVGPGKVLNGLTKRIVGDLQAISVND
CHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEHHH
VASFNAVEEFLV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800