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The map label for this gene is hflK

Identifier: 16272119

GI number: 16272119

Start: 167287

End: 168519

Strand: Reverse

Name: hflK

Synonym: HI0151

Alternate gene names: 16272119

Gene position: 168519-167287 (Counterclockwise)

Preceding gene: 16272120

Following gene: 16272118

Centisome position: 9.21

GC content: 40.79

Gene sequence:

>1233_bases
ATGGAGAATGAAATGTCACAGAACGGTTCAGATCGCGATCCTTGGAGTAAACCAGGGCAAAGCAACGACCAACAGCCGGG
AAATTCATCCAATAATAATGGATGGAATAACAATCAAAATCGTGGAAATCAAGAGCAATCTCCACCAGATATTGAGGAGA
TTTTTAATAATCTGCTTAAAAAATTAGGTGGTGGAAATAAAAAGAGCGGTCAAAATAATGGCAGTTCTCAAGGCAATACG
CCATTTCATTTTGGTAAAGTTATTCCACTTGCTGTAGCGATTGGTGCGATTATTTGGGGCGTAAACGGTTTTTACACCAT
TAAAGAGGCTGAACGCGGTGTGGTGCTTCGTTTTGGCGAGTTACATTCTATTGTTCAACCTGGTTTGAACTGGAAACCAA
CATTTGTAGATAAAGTATTGCCAGTAAATGTGGAGCAAGTAAAAGAGTTGCGTACACAAGGTGCAATGCTGACTCAAGAT
GAAAATATGGTAAAAGTGGAAATGACCGTGCAATATCGTGTGCAAGATCCTGCAAAATATCTTTTTAGCGTAACAAATGC
AGATGATAGTTTGAATCAAGCGACAGATAGTGCATTACGTTATGTTATTGGGCATATGTCTATGAATGATATTTTAACCA
CAGGTCGCTCTGTCGTGCGTGAAAATACTTGGAAAGCTTTGAATGAAATTATCAAATCCTATGATATGGGACTTGAGGTT
ATTGATGTGAACTTCCAATCTGCGCGCCCACCTGAAGAAGTAAAAGATGCGTTTGATGATGCAATTAAAGCGCAGGAAGA
TGAACAACGTTTTATTCGTGAAGCGGAAGCCTATGCGCGTGAGAAAGAACCGATTGCACGTGGTGATGCGCAACGTATTC
TTGAAGAAGCAACAGCTTATAAAGATCGTATCGTGTTAGATGCAAAAGGTGAAGTGGAACGTTTGCAACGCTTGTTGCCA
GAATTTAAGGCTGCGCCAGATTTACTGCGTGAGCGTTTATATATTCAGACGATGGAAAAAGTGATGGCAAATACCCCAAA
AGTAATGCTTGATGGCAATAATGGTAATAATTTAACTGTGTTACCGCTAGAGCAAATTATGGGCAAAAAATCGGTAACAA
GTGCGCCAAGTGCGGTCAATTCTTCGCCTGCTTTTACTGCACCAGAACGTCAAAATTCTTATCAGCCTCAGCCGACTACC
GTTGCGCCGATTCGTCAAGGGAGATTTAACTAA

Upstream 100 bases:

>100_bases
TCCTTATATAAAATCAAGGATTTTTTATTGCCTAAAAAGCCTTGTATTTTCATAGACGTGCCCCATTTATTTAGCTAAAC
TCTTAACAATTTTTTGACAA

Downstream 100 bases:

>100_bases
TGCGTAGATTTTTATTACCTGTTATTTTCGTGATTGCGGCAGTCGTTTATTCTAGTATCGTCGTTGTAACGGAAGGTACG
CGTGGCATTATGTTACGATT

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MENEMSQNGSDRDPWSKPGQSNDQQPGNSSNNNGWNNNQNRGNQEQSPPDIEEIFNNLLKKLGGGNKKSGQNNGSSQGNT
PFHFGKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGELHSIVQPGLNWKPTFVDKVLPVNVEQVKELRTQGAMLTQD
ENMVKVEMTVQYRVQDPAKYLFSVTNADDSLNQATDSALRYVIGHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEV
IDVNFQSARPPEEVKDAFDDAIKAQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAYKDRIVLDAKGEVERLQRLLP
EFKAAPDLLRERLYIQTMEKVMANTPKVMLDGNNGNNLTVLPLEQIMGKKSVTSAPSAVNSSPAFTAPERQNSYQPQPTT
VAPIRQGRFN

Sequences:

>Translated_410_residues
MENEMSQNGSDRDPWSKPGQSNDQQPGNSSNNNGWNNNQNRGNQEQSPPDIEEIFNNLLKKLGGGNKKSGQNNGSSQGNT
PFHFGKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGELHSIVQPGLNWKPTFVDKVLPVNVEQVKELRTQGAMLTQD
ENMVKVEMTVQYRVQDPAKYLFSVTNADDSLNQATDSALRYVIGHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEV
IDVNFQSARPPEEVKDAFDDAIKAQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAYKDRIVLDAKGEVERLQRLLP
EFKAAPDLLRERLYIQTMEKVMANTPKVMLDGNNGNNLTVLPLEQIMGKKSVTSAPSAVNSSPAFTAPERQNSYQPQPTT
VAPIRQGRFN
>Mature_410_residues
MENEMSQNGSDRDPWSKPGQSNDQQPGNSSNNNGWNNNQNRGNQEQSPPDIEEIFNNLLKKLGGGNKKSGQNNGSSQGNT
PFHFGKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGELHSIVQPGLNWKPTFVDKVLPVNVEQVKELRTQGAMLTQD
ENMVKVEMTVQYRVQDPAKYLFSVTNADDSLNQATDSALRYVIGHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEV
IDVNFQSARPPEEVKDAFDDAIKAQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAYKDRIVLDAKGEVERLQRLLP
EFKAAPDLLRERLYIQTMEKVMANTPKVMLDGNNGNNLTVLPLEQIMGKKSVTSAPSAVNSSPAFTAPERQNSYQPQPTT
VAPIRQGRFN

Specific function: HflC and HflK could encode or regulate a protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily

Homologues:

Organism=Escherichia coli, GI1790616, Length=389, Percent_Identity=55.2699228791774, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1786697, Length=225, Percent_Identity=23.1111111111111, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLK_HAEIN (P44546)

Other databases:

- EMBL:   L42023
- PIR:   A64051
- RefSeq:   NP_438321.1
- ProteinModelPortal:   P44546
- SMR:   P44546
- GeneID:   951061
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0151
- NMPDR:   fig|71421.1.peg.143
- TIGR:   HI_0151
- HOGENOM:   HBG465357
- OMA:   WNEPGGN
- ProtClustDB:   CLSK869972
- BioCyc:   HINF71421:HI_0151-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- PRINTS:   PR00721
- SMART:   SM00244
- TIGRFAMs:   TIGR01933

Pfam domain/function: PF01145 Band_7

EC number: NA

Molecular weight: Translated: 45807; Mature: 45807

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xae38728)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENEMSQNGSDRDPWSKPGQSNDQQPGNSSNNNGWNNNQNRGNQEQSPPDIEEIFNNLLK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KLGGGNKKSGQNNGSSQGNTPFHFGKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGE
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHH
LHSIVQPGLNWKPTFVDKVLPVNVEQVKELRTQGAMLTQDENMVKVEMTVQYRVQDPAKY
HHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCEEECCCCEEEEEEEEEEEECCHHHH
LFSVTNADDSLNQATDSALRYVIGHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEV
HEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IDVNFQSARPPEEVKDAFDDAIKAQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAY
EEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KDRIVLDAKGEVERLQRLLPEFKAAPDLLRERLYIQTMEKVMANTPKVMLDGNNGNNLTV
HCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LPLEQIMGKKSVTSAPSAVNSSPAFTAPERQNSYQPQPTTVAPIRQGRFN
EEHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCH
>Mature Secondary Structure
MENEMSQNGSDRDPWSKPGQSNDQQPGNSSNNNGWNNNQNRGNQEQSPPDIEEIFNNLLK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KLGGGNKKSGQNNGSSQGNTPFHFGKVIPLAVAIGAIIWGVNGFYTIKEAERGVVLRFGE
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHH
LHSIVQPGLNWKPTFVDKVLPVNVEQVKELRTQGAMLTQDENMVKVEMTVQYRVQDPAKY
HHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCEEECCCCEEEEEEEEEEEECCHHHH
LFSVTNADDSLNQATDSALRYVIGHMSMNDILTTGRSVVRENTWKALNEIIKSYDMGLEV
HEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
IDVNFQSARPPEEVKDAFDDAIKAQEDEQRFIREAEAYAREKEPIARGDAQRILEEATAY
EEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KDRIVLDAKGEVERLQRLLPEFKAAPDLLRERLYIQTMEKVMANTPKVMLDGNNGNNLTV
HCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LPLEQIMGKKSVTSAPSAVNSSPAFTAPERQNSYQPQPTTVAPIRQGRFN
EEHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800